A5041585341- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Skin and Cellular Biology Research
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Studies on Chitinases and Chitosanases
- Nail Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Mast cells and histamine
- Blood properties and coagulation
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
Hyogo University
2021-2023
Mie University
2003-2023
Futaba clinic
2023
Hyogo Medical University
2013-2022
Institute of Entomology
2021
St. Marianna University School of Medicine
2021
Okayama Prefecture
2021
Medical College of Wisconsin
2015-2018
Osaka University
2013
Bipar
2006
Transgenic mice expressing the mouse interleukin 33 (IL-33) gene driven by a keratin 14 promoter were generated. The skin-selective expression of IL-33 was enhanced, and intense immunofluorescence for evident in nuclei epidermis. Spontaneous itchy dermatitis developed those at 6–8 wk age specific pathogen-free conditions. In lesional skin, epidermis thickened eosinophils infiltrated with increased eosinophil peroxidase major basic protein genes. Mast cells also abundant there, blood...
Abstract Generalized pustular psoriasis ( GPP ) is a rare disease characterized by recurrent fever and systemic flushing accompanied extensive sterile pustules. The committee of the guidelines was founded as collaborative project between Japanese Dermatological Association Study Group for Rare Intractable Skin Diseases under Ministry Health, Labour, Welfare Research Project on Overcoming Diseases. aim to provide current information aid in treatment patients with Japan. Its contents include...
Atopic dermatitis (AD) is a common inflammatory skin disease of unknown etiology. Cutaneous infection with microbes such as Staphylococcus aureus and/or cleansing detergent exacerbates clinical AD. Here, we generated an AD animal model by destroying barrier function and subsequent topical application protein A from S. (SpA). NC/Nga mice, which genetically have reduced function, BALB/c mice having intact were susceptible to this combination developed severe moderate AD, respectively,...
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ activation when expressed on antigen-presenting cells. Vsir -/- mice developed loss peripheral tolerance multi-organ chronic inflammatory phenotypes. cells were hyper-responsive towards self- foreign antigens. Whether or not VISTA regulates innate immunity unknown. Using a murine model psoriasis induced by TLR7 agonist imiquimod (IMQ), we show deficiency...
Programmed cell death 1 (PD-1) is a key regulatory molecule that has been targeted in human cancers, including melanoma. In clinical testing, Abs against PD-1 have resulted psoriasiform dermatitis (PsD). To determine whether regulates PsD, we compared skin responses of PD-1-deficient (PD-1KO) mice and wild-type (WT) controls an imiquimod (IMQ)-induced murine model psoriasis. PD-1KO showed severe epidermal hyperplasia, greater neutrophilic infiltration, higher expression Th17 cytokines...
Psoriasis is a chronic inflammatory skin disease characterized by the infiltration of T cell and other immune cells to in response injury or autoantigens. Conventional, as well unconventional, γδ are recruited dermis epidermis CCL20 chemokines. Together with its receptor CCR6, plays critical role development psoriasiform dermatitis mouse models. We screened panel variants designed form dimers stabilized intermolecular disulfide bonds. A single-atom substitution yielded variant (CCL20 S64C)...
Group 2 innate lymphoid cells (ILCs) are thought to contribute the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type (Th2) and ILC2s proliferate produce cytokines. Dupilumab, an antibody against receptor, is used in AD therapy. We speculated that its efficacy might involve blocking activation Th2 via IL-4. Here, we examined circulating 27 Japanese patients with before after administration dupilumab. Between 0 4 months dupilumab administration, percentages were decreased....
Abstract In a transgenic mouse line hK14mIL33tg, with the expression of interleukin-33 (IL-33) driven by keratin 14 promoter, keratoconjunctivitis developed spontaneously between 18 and 22 weeks age under specific-pathogen-free conditions. These mice showed blepharitis corneal impairments, histology revealed epithelial thickening in conjunctiva cornea infiltration eosinophils, mast cells basophils. IL-5, IL-13 CCL11 were abundant lacrimal fluid mice, gene expressions IL-4, IL-13, IL-33, Prg2...
To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 samples from 6 cases with GPP during course disease. Serum IL-4, IL-8, CXCL1 and CCL3 were positively correlated scores GPP, white blood cell counts C-reactive protein levels. IL-1 β , IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN- γ VEGF showed strong positive correlations ( r > 0.4, p < 0.01) all those 3 clinical markers. Of those,...
A 78-year-old woman who had been suffering from psoriasis vulgaris for 31 years was admitted to hospital because of her erythroderma. toxic eruption suspected and she treated with prednisolone 30 mg daily. However, it ineffective and, suspecting psoriatic erythroderma, cyclosporine 150 daily administered tapering the prednisolone. Two weeks after a dose reduction 100 mg/day, erythroderma widespread generalized pustules fever developed. Histology biopsy revealed inflammatory infiltrates in...
Abstract is missing (Short communication)
Abstract The stratum corneum (SC) of the epidermis acts as a skin permeability barrier, and abnormalities in SC formation lead to several disorders. Lipids, especially epidermis‐specific ceramide classes ω‐ O ‐acylceramides (acylceramides) protein‐bound ceramides, are essential for barrier formation. Ceramide synthase 3 (CERS3) is involved synthesis acylceramides CERS3 mutations cause autosomal recessive congenital ichthyosis. In present study, we measured activity performed comprehensive...
Systemic amyloidosis is recognized as a serious complication of rheumatoid arthritis or inflammatory bowel disease, but also skin disease. However, the detailed molecular mechanism associated with cutaneous inflammation remains unclear, and therapeutic approaches are limited. Here, we investigated pathophysiology secondary to effects Janus kinase (JAK) inhibitors by examining mouse model spontaneous dermatitis (KCASP1Tg mice). Moreover, KCASP1Tg mice were crossed interleukin-17A (IL-17A)...
To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 samples from 6 cases with GPP during course disease. Serum IL-4, IL-8, CXCL1 and CCL3 were positively correlated scores GPP, white blood cell counts C-reactive protein levels. IL-1β, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-γ VEGF showed strong positive correlations (r>0.4, p<0.01) all those 3 clinical markers. Of those, IL-10 IL-22...
Mutations of the transglutaminase 1 gene (TGM1) are a major cause autosomal recessive congenital ichthyoses (ARCIs) that associated with defects in skin barrier structure and function. However, molecular processes induced by deficiency not fully understood. The aim present study was to uncover those analysis cutaneous signatures. Gene expression profiles wild-type Tgm1-/-epidermis were assessed using microarrays. ontology data showed genes for innate defense responses up-regulated...
Abstract Protease‐activated receptor 2 (PAR2) is a G protein‐coupled which mediates variety of functions in the skin including cutaneous inflammation. SLIGKV‐NH , an agonist peptide for PAR2, enhanced interleukin (IL)‐17‐induced production two CXC chemokines, CXCL1 (GRO‐α) and CXCL8 (IL‐8), normal human epidermal keratinocytes (NHEK) concentration‐dependent manner. The those chemokines was suppressed by PAR2‐specific siRNA. ‐induced both markedly reduced cyclosporine A. 1α,...