A5103004455- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Skin and Cellular Biology Research
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Biological Activity of Diterpenoids and Biflavonoids
- Psoriasis: Treatment and Pathogenesis
- Synthesis of Organic Compounds
- Autoimmune Bullous Skin Diseases
- Allergic Rhinitis and Sensitization
- Ginseng Biological Effects and Applications
- Food Allergy and Anaphylaxis Research
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Seaweed-derived Bioactive Compounds
- Metabolism and Genetic Disorders
- Marine Sponges and Natural Products
- NF-κB Signaling Pathways
- Aldose Reductase and Taurine
Jikei University School of Medicine
2024
Hyogo University
2022-2023
Hyogo Medical University
2015-2022
Hoshi University
1996-1997
Tokushima Bunri University
1995
Osaka University
1993
The University of Tokyo
1964
Group 2 innate lymphoid cells (ILCs) are thought to contribute the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type (Th2) and ILC2s proliferate produce cytokines. Dupilumab, an antibody against receptor, is used in AD therapy. We speculated that its efficacy might involve blocking activation Th2 via IL-4. Here, we examined circulating 27 Japanese patients with before after administration dupilumab. Between 0 4 months dupilumab administration, percentages were decreased....
Abstract In a transgenic mouse line hK14mIL33tg, with the expression of interleukin-33 (IL-33) driven by keratin 14 promoter, keratoconjunctivitis developed spontaneously between 18 and 22 weeks age under specific-pathogen-free conditions. These mice showed blepharitis corneal impairments, histology revealed epithelial thickening in conjunctiva cornea infiltration eosinophils, mast cells basophils. IL-5, IL-13 CCL11 were abundant lacrimal fluid mice, gene expressions IL-4, IL-13, IL-33, Prg2...
We previously generated a transgenic mouse line expressing skin-specific IL-33 (IL33tg mice) and showed that elicits group 2 innate lymphoid cell (ILC2)-dependent atopic dermatitis-like skin inflammation. ILC2s are believed to be tissue-resident cells under steady-state conditions, but the dynamics of ILC2 migration not fully understood. sorted from draining lymph nodes IL33tg mice analyzed their transcriptomes using single-cell RNA sequencing technique, which revealed had split into two...
Abstract We report a case of 12‐year‐old boy who was born as collodion baby after which thick scales developed on his entire body surface. His younger brother showed similar skin condition. Arcuate‐shaped, large, brownish covered face with ectropion. lower legs were also larger thick, brownish, plate‐like scales, but other areas smaller scales. Next‐generation sequencing for exons and splice sites detected stop‐gain TGM1 mutation leading to p.R71* in transglutaminase 1 (TG1). Another...
Autosomal recessive congenital ichthyosis (ARCI) is an entity of rare genetic skin disorders with abnormal keratinization (1).Harlequin the most severe type ARCI, usually caused by truncation mutations in ABCA12.In subtypes such as lamellar ichthy osis (LI) and, ichthyosiform erythroderma (CIE) TGM1, ABCA12, NIPAL4, ALOXE3, ALOX12B, CERS3, CYP4F22 and PNPLA1 have been reported (2-4).Mutations gene encoding NIPA-like domain containing 4 protein (NIPAL4/ichthyin) (5), identified approximately...
Patients with generalized pustular psoriasis (GPP) often present symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT P-SEP levels in patients psoriatic diseases. The enrolled included 27 vulgaris (PV) (22 males, 5 females; mean age 47.7 years), 12 arthritis (PsA) (8 4 51.3 15 GPP (10 63.7 years). PV, PsA, were 0.01 ng/mL (25th-75th percentile; 0.00-0.03), 0.013 (0.00-0.03),...
Interleukin-33 (IL-33) is involved in type 2 innate immunity by inducing cytokines, such as IL-5 and IL-13, through the activation of group lymphoid cells (ILC2s) or T helper (Th2) cells. We previously reported that mice overexpressing IL-33 (IL-33Tg) cornea conjunctiva spontaneously develop atopic keratoconjunctivitis-like inflammation. Despite previous studies, it not fully understood what types immune contribute to disease process IL-33-induced keratoconjunctivitis.To defect Th2 cells,...
The intravenous olfactory test (alinamin [AT]) is a retronasal assessment and may evaluate the flavour disorder; however, studies assessing whether AT accurately determines severity of taste disorders are lacking. Our study aims to relationship between subjective in patiensts with disorder.
We investigated the usefulness of Atopic Dermatitis Control Tool (ADCT) in patients with AD treated dupilumab daily clinical practice. The ADCT score correlated scores other measurement instruments (POEM, DLQI, and EASI) during after treatment. Furthermore, were <7 most who receiving therapy or those bio-free remission discontinuation therapy.
Dupilumab (DUP) is the first biological agent used treating atopic dermatitis (AD). Notwithstanding its high cost, type of patient group for which drug effective remains unclear. In this retrospective study, we aimed to identify novel and reliable biomarkers can be measured before DUP administration predict efficacy DUP. Serum samples from 19 patients with AD treated were analysed by metabolome analysis using gas chromatography–mass spectrometry. Total 148 metabolites detected, relative...
A case of adalimumab-induced interstitial lung disease that was successfully controlled with ixekizumab in a patient psoriatic arthritis. Dear Editor, TNF-α inhibitors, including adalimumab (ADA), increase serum Krebs von den Lungen (KL)-6 levels or without the occurrence (ILD).1, 2 Herein, we report ADA-induced ILD (IXE) Case: 60-year-old man history moderate psoriasis presented as an outpatient exacerbation rash. At previous hospital, ADA monotherapy had been used treatment for 16 months...
ABSTRACT A 70‐year‐old man’s chronic erythematous skin lesion in the extremity had developed into a tumour one year before his first visit at our hospital. biopsy showed atypical lymphocyte‐like cells, and immunostaining identified cells as CD3+, CD4+, CD5+ FOXP3+. Single‐cell RNA sequencing (scRNA‐seq) analysis using BD Rhapsody revealed higher expression of CD3 , CD4 CD5 FOXP3 genes group that highly expressed genes, such PCNA S/M phase, which is agreement with immunofluorescence staining...