Abstract Psoriasis, a chronic, immune‐mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim this open‐label study was to evaluate long‐term efficacy and safety ixekizumab, humanized, anti‐interleukin‐17A monoclonal antibody, Japanese patients with plaque psoriasis ( n = 78, including 11 psoriatic arthritis), erythrodermic 8) generalized pustular 5). Ixekizumab administrated s.c. at baseline (week 0, 160 mg), from weeks 2 12...

Abstract Background Erythrodermic and generalized pustular psoriasis are rare, difficult to treat forms of psoriasis. In previous reports, we documented 24‐ 52‐week findings an open‐label, phase 3 trial ( UNCOVER ‐J) ixekizumab in Japanese patients with erythrodermic or psoriasis; most responded treatment maintained response through 52 weeks. Objective To assess the long‐term (>3 years) efficacy safety Methods These subgroup analyses were a partial population from ‐J NCT 01624233;...

Treatment for lung cancer continues to rapidly evolve. Here, we describe trends in the initial treatment of adults with newly diagnosed primary non-small-cell Japan. This retrospective cohort study used data from JMDC Inc. Claims Database 2015 2023. Adults cancer, confirmed using a combination diagnosis, treatment, or procedure codes, were enrolled. A total 9373 patients included, mean age approximately 59 years. The median time diagnosis initiation ranged 38 days treated surgically 25...

BackgroundThe epidemiological importance of asymptomatic individuals who would never develop illness, compared to those eventually symptoms, has yet be fully clarified.MethodsThe very first cluster data in Tokyo and Kanagawa (n = 36) were analyzed. Movement all close contact was restricted for 14 days they underwent laboratory testing with polymerase chain reaction. The reproduction numbers symptomatic cases estimated.ResultsThe number estimated 1.2 (95% confidence interval (CI): 0.5–2.9)....

Abstract Background Long‐term management of moderate‐to‐severe psoriasis is usually discussed in terms continuous administration; however, there are many situations clinical practice where treatment may be withdrawn with subsequent retreatment. Objective To assess the course after ixekizumab withdrawal and retreatment, as well effectiveness Japanese patients plaque psoriasis. Methods This single‐arm, open‐label study ( UNCOVER ‐J; NCT01624233) comprised 78 After (160‐mg loading dose, 80 mg...

Abstract Purpose This study is to describe patient demographic characteristics and estimate annual prevalence incidence rates of Crohn’s disease (CD) in Japan the United States (US). Methods Two large employment-based healthcare claims databases (Japan Medical Data Center [JMDC] Merative MarketScan [Merative] US) were used identify patients with CD from 2010 2019. Cases confirmed using an algorithm based on diagnostic with/without treatment codes. The population was for sex age...

To examine the long-term efficacy and safety of duloxetine in treatment Japanese patients with diabetic neuropathic pain, we carried out a 52-week, randomized, open-label extension 12-week, double-blind, placebo-controlled study.Japanese adults pain who completed double-blind study were eligible for this study, at 71 sites Japan (March 2008 to March 2010). Participants (n = 258) re-randomized (1:1) 40 mg/day or 60 duloxetine. Pain (Brief Inventory severity interference), quality life...

Estimation of the effective reproduction number, R(t), coronavirus disease (COVID-19) in real-time is a continuing challenge. R(t) reflects epidemic dynamics based on readily available illness onset data, and useful for planning implementation public health social measures. In present study, we proposed method computing COVID-19, applied this to Osaka prefecture from February September 2020. We estimated as function time infection using date onset. The came under control around 2 April...

Abstract Background Individuals with asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can propagate the virus unknowingly and thus have been a focus of public health attentions since early stages pandemic. Understanding viral transmissibility among individuals is critical for successful control coronavirus disease 2019 (COVID-19). The present study aimed to understand SARS-CoV-2 young assess whether symptomatology was associated transmission symptomatic vs....

To understand the current state of treatment patterns and health care resource utilization among patients in Japan with ankylosing spondylitis (AS) managed real-world setting.Patient records from Medical Data Vision database were analyzed to identify ICD-10 AS April 2009 through July 2017. Measures evaluated included demographic, clinical, other characteristics at diagnosis; patterns; utilization; costs.Four hundred seventeen met study's inclusion criteria. Treatments observed during first...

R(t), the actual average number of secondary cases per primary case at calendar time t, is epidemiologically useful in assessing transmission dynamics a population with varying susceptibility levels. However, technical limitation existing methods estimating R(t) reliance on daily illness onset and distribution serial interval, although estimator should be calculated as ratio newly infected t to total potentially infectious people same time. Using historical data smallpox outbreak Tokyo City,...

Elucidating the infection dynamics that lead to severe respiratory syncytial virus (RSV) pneumonia and hospitalization among young children are critical. We explored role of parity as well age in months for RSV-associated Japan.We used a sequential transmission catalytic model capture mechanisms RSV infants an endemic state. investigated data on age-dependent seroprevalence incidence rate Japan, jointly estimated age-specific risk during primary relative secondary aged <5 years.The with was...

There are few studies that comprehensively report real-world persistence for first-line advanced therapies used to treat inflammatory bowel disease. We aimed describe of among incident biologic or Janus kinase inhibitor users with Retrospective cohort study using the Japan Medical Data Center database from January 1, 2010, until September 30, 2022. Patients aged ≥15 years relevant diagnostic and treatment codes were included. All eligible patients observed end (September 2022), death,...

Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the axial skeleton associated with impaired health-related quality life (QoL) and disability. Objectives: To better understand symptoms, clinical characteristics, treatment patterns, (QoL), non-radiographic (nr-axSpA) patients how they compare to ankylosing spondylitis (AS) in Japan. Methods: Data from cross-sectional survey conducted physician (rheumatologists, orthopedic surgeon, internal medicine) their...

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