A5078432414- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Skin Diseases and Diabetes
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological and COVID-19 studies
- Actinomycetales infections and treatment
- Spondyloarthritis Studies and Treatments
- Thermoregulation and physiological responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Drug-Induced Adverse Reactions
- Infectious Diseases and Tuberculosis
- Health Systems, Economic Evaluations, Quality of Life
Kawasaki Medical School
2022-2024
Abstract Previous studies on family history of psoriasis showed that patients with a have an earlier onset the disease, but such in Japan are still limited. To elucidate characteristics familial psoriasis, we studied using West Psoriasis Registry, multi‐institutional registry operated by 26 facilities western part Japan, including university hospitals, community and clinics. This study enrolled 1847 registered between September 2019 December 2021, 199 (10.8%) having psoriasis. Patients had...
Although subtle barrier defects may facilitate allergen penetration, thereby enabling allergic sensitization, the relationship between sweating disturbance and skin function is unknown. However, many studies on contact hypersensitivity in mice examined ear skin, which does not sweat, instead of footpad, where uniquely present. In this study, we assessed whether sweat suppression footpad before hapten application provoked a abnormality reduced inflammatory thresholds to topical haptens. Mice...
Abstract Bullous systemic lupus erythematosus (BSLE) is a rare blistering disease in patients with SLE. BSLE heterogenous caused by autoantibodies to the basement membrane, mainly type VII collagen. The pathogenesis of development remains unknown. We report case SLE taking dipeptidyl peptidase 4 inhibitors (DPP4i) who developed tense blister lesions after administration SARS‐CoV‐2 vaccine. Initial erythematous lesion before vaccine had not shown IgG deposition at membrane both direct and...
Abstract Clinical trials of biologics have frequently excluded elderly patients, resulting in inadequate data on their safety and efficacy. Additionally, evidence efficacy remains limited, despite some real‐world studies. To assess the patients with psoriasis, we compared these outcomes younger using from West Japan Psoriasis Registry (WJPR). The WJPR consists approximately 30 facilities Western Japan, including various healthcare settings. This study enrolled 1395 who participated 2022...
Abstract Background Many reports have described the development of bullous pemphigoid (BP) following COVID‐19 vaccination. In dipeptidyl peptidase‐4 inhibitor‐associated BP (DPP‐4i‐BP), cessation DPP‐4i appears to a paradoxical effect on clinical course BP. Interestingly, similar reactions been shown develop after antibody‐based therapies that inhibit pro‐inflammatory cytokine signalling. These heterogenous outcomes could be explained by assuming DPP‐4i‐BP is manifestation immune...