A5075363080- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Eosinophilic Disorders and Syndromes
- Immunotherapy and Immune Responses
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- Contact Dermatitis and Allergies
- Skin Diseases and Diabetes
- Inflammatory Myopathies and Dermatomyositis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ear and Head Tumors
- Vector-Borne Animal Diseases
Saga University
2021-2025
Khon Kaen University
2024
Tottori University
2016-2023
University of Zurich
2015-2020
CK-CARE
2015-2020
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
Tokai University
2017
Tokyo University of Technology
2017
Skin is an immunological organ consisting of epidermal cells, i.e. keratinocytes and Langerhans cells (LCs, antigen-presenting dendritic cells), both innate acquired immune systems operate upon exposure the skin to various external microbes or their elements. To explore relationship between immunities in skin, we investigated whether Toll-like receptor (TLR) ligation enhances ability LCs present a specific antigen T mice. LC-containing were incubated with CpG oligonucleotide (TLR9 ligand)...
Acute generalized exanthematous pustulosis (AGEP) is a diffuse pustular disorder that usually begins in intertriginous folds with widespread erythema. The causes the majority of cases are drugs. T cells and interleukin (IL)-8 play roles development AGEP, but mechanism remains to be elucidated. We investigated involvement Th17 their cytokine IL-22 pathogenesis.Three patients AGEP were enrolled this study. percentages IL-17(+) cells, interferon γ(+) IL-4(+) measured patients' peripheral blood...
Abstract Adult T‐cell leukemia/lymphoma (ATL) is a CD4 + CD25 malignancy infected with human leukemia virus type‐I (HTLV‐I). HTLV‐I infection causes the dysfunction, which contributes to immunodeficient state of patients. Programmed death‐1 (PD‐1) can negatively regulate response, when its ligand, PD‐L1 or PD‐L2 mainly expressed on antigen presenting cells, binds this B7 family receptor. We investigated whether PD‐1 neoplastic (and/or non‐neoplastic) cells CD8 cytotoxic in peripheral blood...
Abstract Previous studies on family history of psoriasis showed that patients with a have an earlier onset the disease, but such in Japan are still limited. To elucidate characteristics familial psoriasis, we studied using West Psoriasis Registry, multi‐institutional registry operated by 26 facilities western part Japan, including university hospitals, community and clinics. This study enrolled 1847 registered between September 2019 December 2021, 199 (10.8%) having psoriasis. Patients had...
Abstract The mechanism underlying the local UVB-induced immunosuppression is a central issue to be clarified in photoimmunology. There have been reported considerable number of cells and factors that participate sensitization phase-dependent suppression, including Langerhans (LCs), regulatory T cells, IL-10, TNF-α. recent important finding LC-depleted mice rather exhibit enhanced contact hypersensitivity responses urged us re-evaluate role LCs along with dermal dendritic (dDCs)...
Psoriasis affects approximately 0.3% of the Japanese population. Recently, various effective systemic drugs have become available, and continuation a given treatment has critical because chronic nature psoriasis. Factors affecting drug survival (the time until discontinuation) in psoriasis include efficacy, safety, ease use, patient preference. In present study, authors retrospectively surveyed multifacility registry to determine real-world evidence rate interventions for treatment. Patients...
The phrase “skin as a mirror of internal medicine,” which means that the skin reflects many diseases organs, is well-known notion. Despite phenotypic differences between soft and hard bone, bone are highly associated. Skin consist fibroblasts osteoblasts, respectively, secrete collagen involved in synthesis, while Langerhans cells osteoclasts control turnover. Moreover, quality quantity may be modified by aging, inflammation, estrogen, diabetes, glucocorticoids. pathologically drugs,...