A5037667479- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Nail Diseases and Treatments
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Genetic and rare skin diseases.
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cancer and Skin Lesions
- Drug-Induced Adverse Reactions
- Fungal Infections and Studies
- Oral Health Pathology and Treatment
- Skin Diseases and Diabetes
- Galectins and Cancer Biology
National Defense Medical College
2016-2025
Japanese Urological Association
2024
Iwate Medical University
2021-2023
Nagoya University
2020-2023
National Defense Medical College Hospital
2013-2021
Toho University
2019
Nara Medical University
2018
Tokyo Medical and Dental University
2005-2016
National Defense Academy of Japan
2016
Jikei University School of Medicine
2013
To cite this article: Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy 2011; 66: 1107–1113. Background: Basophils are blood leukocytes constituting less than 1% of leukocytes. They share morphological functional similarities with mast cells, but recent studies indicate that basophils play non-redundant roles via the release several cytokines lipid mediators, as well functioning antigen presenting cells....
Abstract PGD2 plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of gene to investigate functional cutaneous inflammatory responses. CRTH2-deficent were fertile grew normally. Ear-swelling responses induced by hapten-specific IgE less pronounced mice, giving 35–55% normal mice. Similar results seen treated with hemopoietic...
Abstract Acquired idiopathic generalized anhidrosis ( AIGA ) is characterized by an acquired impairment in total body sweating despite exposure to heat or exercise. Severe cases may result heatstroke. Most of have been reported Asia, especially Japan. However, there limited information on the epidemiology this condition, and no diagnostic criteria appropriate treatment options established. This guideline was developed fill gap. It contains etiology, diagnosis, evaluation disease severity...
Contact hypersensitivity (CHS) is thought to be mainly associated with the activation of T helper type 1 (Th1) cells. However, there also evidence that Th2 cells or cytokines play a role in development CHS. To analyze functional contribution interleukin (IL)-4 and IL-13, signal transducer activator transcription 6 (STAT6)-deficient (STAT6(-/)-) wild-type (wt) control C57BL/6 mice were contact sensitized 5% 2,4,6-trinitrochlorobenzene (TNCB), 0.5% 2,4-dinitrofluorobenzene, 4-ethoxyl...
Collagen was identified as a fish allergen in early 2000s. Although its allergenic potential has been suggested to be low, risks associated with collagen have not evaluated greater extent. In this study, we aimed clarify the importance of allergen. Our results showed that 50% Japanese patients allergy had immunoglobulin E (IgE) against mackerel collagen, whereas 44% IgE parvalbumin. inhibition assay revealed high cross-reactivity 22 species (inhibition rates: 87–98%). Furthermore, recently...
Scabies is a common contagious skin disease caused by an infestation of the Sarcoptes scabiei var. hominis. A hallmark symptom scabies severe itch.We sought to determine generation pruritogenic cytokine, interleukin (IL)-31, together with immune profiles in lesions ordinary through immunohistochemical and immunofluorescent studies. To elucidate pathological mechanisms IL-31 generation, murine peritoneal macrophages were stimulated various T helper 2 (Th2) cytokines proteins ex vivo.A large...
The diabetic heart is resistant to ischemic preconditioning because of diabetes-associated impairment phosphatidylinositol 3-kinase (PI3K)-Akt signaling. mechanism by which PI3K-Akt signaling impaired diabetes remains unclear.Here, we examined the hypothesis that phosphorylation Jak2 upstream PI3K in hearts an angiotensin II type 1 (AT1) receptor-mediated mechanism.Infarct size (as percentage risk area) after 20-minute ischemia/2-hour reperfusion was larger a rat model 2...
Prostaglandin D2 (PGD2), an arachidonic acid metabolite, has been implicated in allergic responses. A major source of PGD2 the skin is mast cells that express hematopoietic PGD synthase (H-PGDS). In this study, we show expression H-PGDS human dendritic (DCs) and regulatory mechanisms by which DCs produce PGD2. We detected epidermal Langerhans cells, dermal DCs, plasmacytoid myeloid DCs. Monocyte-derived rapidly secreted when stimulated with calcium ionophore A23187. More importantly,...
Urate transporter 1 (URAT1/SLC22A12), a urate gene, is causative gene for renal hypouricemia type 1. Among several reported nonsynonymous URAT1 variants, R90H (rs121907896) and W258X (rs121907892) are frequent mutations hypouricemia. However, no case-control study has evaluated the relationship between gout these two variants. Additionally, effect size of variants on serum uric acid (SUA) levels remains to be clarified. Here, 1,993 primary patients 4,902 health examination participants...
Itch accompanies various skin diseases. As a number of mediators other than histamine can be involved in the itch sensation, H1 receptor antagonists are not necessarily effective treating itch. External application antipruritic drugs is occasionally used as an alternative therapy for pruritic conditions, such pruritus on primary non-diseased, non-inflamed skin. Even so, actual effects these sensation have yet to studied detail. To verify crotamiton, capsaicin, and corticosteroid we examined...
Psoriasis is a chronic skin disease mediated by Th17 and/ or Th1 cells.Tim-3 cell surface molecule preferentially expressed on and cells.The interaction of Tim-3 with ligand inhibits cytokine production.To assess whether T cells in psoriasis have functional abnormalities, expression blood producing interleukin-17 (Th17/Tc17 cells) interferon-γ (Th1/Tc1 was examined flow cytometry.Psoriasis patients had higher numbers Tc17 cells, as well Tc1 than healthy donors.However, Th17, did not...
Abstract Prurigo is a common, but treatment-resistant, skin disease characterized by persistent papules/nodules and severe itching. occurs in association with various underlying diseases, such as diabetes, chronic renal failure, internal malignancies. Atopic dermatitis occasionally complicated prurigo lesions. However, the pathology of completely undefined. We demonstrate that repeated intradermal administration Ag to IgE-transgenic mice causes pruritic papulonodular lesions mimicking...
Two classes of tetracycline resistance determinants on R plasmids were detected in Vibrio anguillarum strains isolated from ayu (sweat fish; Plecoglossus altivelis) farms Japan. Tetracycline genes categorized as class B prevalent 1973 to 1977; however, a new gene, which was not classified into determinant A, B, C, or D, has been since 1981.
Summary Background Airborne contact dermatitis to cedar pollen is a recently identified disease that generally affects individuals with pollinosis of the nasal and/or ocular symptoms, as well some patients atopic dermatitis. Objective To elucidate pathological mechanisms Methods We established mouse model by epicutaneous sensitization Japanese antigen (Ag). Results Histologically, there was marked dermal cellular infiltrate, including eosinophils and mast cells, epidermal thickening. The...
Gout is a common disease resulting from hyperuricemia which causes acute arthritis. Recently, genome-wide association studies revealed an between serum uric acid levels and variant of leucine-rich repeat-containing 16A (LRRC16A) gene. However, it remains to be clarified whether LRRC16A contributes the susceptibility gout. In this study, we investigated relationship rs742132 in A total 545 Japanese male gout cases 1,115 individuals as control group were genotyped. A/A genotype significantly...
Prostaglandin (PG) D2 and PGE2 are arachidonic acid metabolites that generated though an isomerization reaction catalyzed by PG synthases. PGs have been implicated in immunologic reactions addition to a wide range of physiological functions. It has long thought basophils, contrast mast cells, do not synthesize PGs, although they release leukotrienes platelet-activating factor. Here, we show basophils function as source PGD2 PGE2. In vitro-cultured from mouse bone marrow produced both...