A5000664738- Cardiac pacing and defibrillation studies
- Gout, Hyperuricemia, Uric Acid
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- COVID-19 and Mental Health
- Posttraumatic Stress Disorder Research
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Impact of Technology on Adolescents
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Case Reports on Hematomas
- Stress Responses and Cortisol
- Cardiovascular Effects of Exercise
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Metabolism and Genetic Disorders
- Glaucoma and retinal disorders
- Cardiovascular Health and Disease Prevention
- Child Development and Digital Technology
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Neurological disorders and treatments
- Cardiovascular Disease and Adiposity
Chiba University
2021-2025
Self-Defense Forces Central Hospital
2019-2024
Advanced Telecommunications Research Institute International
2018-2024
National Defense Medical College
2008-2024
Kobe University
2019-2024
KDDI Research (Japan)
2024
National Center of Neurology and Psychiatry
2024
Toho University
2019
Toho University Omori Medical Center
2019
Nagoya University
2014
Gout based on hyperuricemia is a common disease with genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in gout-susceptibility locus chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 high-capacity urate secretion transporter. Sequencing the gene 90 patients revealed several nonfunctional mutations, including Q126X. Quantitative trait analysis...
Internet gaming disorder (IGD) and problematic internet use (PIU) are becoming increasingly detrimental to modern society, with serious consequences for daily functioning. IGD PIU may be exacerbated by lifestyle changes imposed the coronavirus 2019 (COVID-19) pandemic. This study investigated in during pandemic risk factors them. is a part of larger online smartphone Japan, originally planned 2019, expanded August 2020 include impact COVID-19. 51,246 adults completed an survey (August 2020),...
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and subtypes remains unclear. Here, we first performed GWAS clinically defined only. Methods A conducted with 945 patients 1213 controls Japanese male population, followed replication study 1048 1334 controls....
Significance Conventional therapies for the treatment of anxiety disorders are aversive, and as a result, many patients terminate prematurely. We have developed an unconscious method to bypass unpleasantness in conscious exposure using functional magnetic resonance imaging neural reinforcement. Using this method, participants learn generate brain patterns similar multivariate pattern feared animal. demonstrate double-blind placebo-controlled experiment that reinforcement can lead reliable...
Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 major cause renal overload (ROL) hyperuricemia, but its involvement in underexcretion (RUE) most prevalent subtype, not clearly explained so far. In this study, association analysis with 644 hyperuricemia patients and 1,623 controls male Japanese revealed significantly increased risk RUE as well overall ROL according to severity impairment. caused induced even if was...
Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether dysfunction ABCG2, high-capacity urate transporter regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset data and 1,887 controls were genotyped, ABCG2 functions are estimated by its genotype combination determined. The was 6.5 years earlier severe than normal function (P = 6.14 × 10(-3)). Patients...
Objective Serum uric acid (SUA) levels in humans are mainly regulated by urate transporters. Recent genome‐wide association studies suggested that common variants of the human sodium‐dependent phosphate cotransporter type 1 gene ( NPT1/SLC17A1 ) influence SUA. NPT1 has been reported to mediate transport, but its physiologic role regulating SUA remains unclear. Furthermore, findings replication relationship between and gout have inconsistent. The aims this study were investigate effect on...
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, dysfunctional variants of ABCG2, urate exporter gene also known as BCRP, are revealed to be major cause gout/hyperuricemia. Here, we compared the influence ABCG2 dysfunction on serum uric acid (SUA) levels with other risk factors in cohort 5,005 Japanese participants. was observed 53.3% population investigated and its population-attributable percent (PAR%) for hyperuricemia 29.2%, much higher...
Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels. From viewpoint of urate handling in humans, gout patients can be divided into those with renal overload (ROL) intestinal underexcretion, and underexcretion (RUE) gout. Recent genome-wide association studies (GWAS) revealed an between SUA variant human monocarboxylate transporter 9 (MCT9/SLC16A9) gene. Although the function MCT9 remains unclear, mostly excreted via intestine kidney where...
Background: The HELT-E2S2score, a novel risk stratification system, was developed to determine the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation (NVAF). It has been suggested that HELT-E2S2score is more useful than CHADS2and CHA2DS2-VASc scores for NVAF. This study determined NVAF and cardiac implantable electronic devices (CIEDs) assessed validity this population.
Renal hypouricemia (MIM 220150) is an inherited disorder characterized by low serum uric acid levels and has severe complications such as exercise-induced acute renal failure urolithiasis. We have previously reported that URAT1/SLC22A12 encodes a urate-anion exchanger its mutations cause type 1 (RHUC1). With the large health-examination database of Japan Maritime Self-Defense Force, we found two missense (R198C R380W) GLUT9/SLC2A9 in patients. R198C R380W occur highly conserved amino motifs...
ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels gout/hyperuricemia risk. Generally, hyperuricemia been classified into "overproduction type," "underexcretion "combined type" based on only renal excretion, without considering extra-renal pathway such gut excretion. In this study, we investigated the effects of ABCG2 human handling mechanism...
With the spread of smartphones and computer games, concerns have escalated regarding rising prevalence gaming disorder. Patients often display attentional biases, unconsciously turning their attention towards gaming-related stimuli. However, attempts to discover ameliorate these deficits yielded inconsistent outcomes, potentially due dynamic nature bias. This study investigated neural mechanisms underlying bias state by combining neuroimaging (functional magnetic resonance imaging -fMRI)...
Gout is a common disease resulting from hyperuricemia which causes acute arthritis. Recently, genome-wide association studies revealed an between serum uric acid levels and variant of leucine-rich repeat-containing 16A (LRRC16A) gene. However, it remains to be clarified whether LRRC16A contributes the susceptibility gout. In this study, we investigated relationship rs742132 in A total 545 Japanese male gout cases 1,115 individuals as control group were genotyped. A/A genotype significantly...
Uric acid (urate) has been suggested to play a protective role in Parkinson's disease onset through its antioxidant activity. Dysfunction of ABCG2, high-capacity urate exporter, is major cause for early-onset gout based on hyperuricemia. In this study, the effects dysfunctional ABCG2 variant (Q141K, rs2231142) were analyzed ages at patients (N = 507) and 1015). The Q141K hastened (P 0.0027), but significantly associated with later 0.025). Our findings will be helpful development more...
Abstract The coronavirus disease 2019 (COVID-19) pandemic has profoundly affected the mental health of both infected and uninfected people. Although most psychiatric disorders have highly overlapping genetic pathogenic backgrounds, studies investigating impact examined only single disorders. It is necessary to examine longitudinal trajectories factors that modulate states across multiple dimensions. About 2274 Japanese citizens participated in online surveys presented December (before...
Antithrombotic therapy after left atrial appendage closure (LAAC) in patients at high risk of bleeding remains controversial. We present real-world clinical outcomes LAAC.
To investigate the effects of a non-steroidal anti-inflammatory drug (NSAID) ophthalmic solution on latanoprost induced intraocular pressure (IOP) reduction in glaucoma patients.Examination was conducted 16 eyes patients who had been given only for at least 6 weeks. The NSAID solution, sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate, additionally 12 weeks into one eye (NSAID group), while hyaluronic acid administered other (control group) double masked fashion. IOP measurement...
ABSTRACT Recent time-dependent analyses of stress-related disorders have identified heterogeneity trajectories and their modifying factors. While psychiatric patients are vulnerable to stress events, it is unclear how conditions in the general population modulate subsequent responses. Using our longitudinal online survey from before COVID-19 pandemic post-pandemic follow-ups (n = 3815 Japanese adults), here we four post-traumatic symptoms (PTSS) a latent growth mixture model; resilient,...
Fear memories enhance survival especially when the guide defensive movements to minimize harm.Accordingly, fear and body have tight relationships in animals: memory acquisition results adapting reactive defense movements, while training active reduces memory.However, evidence humans is scarce because their are typically suppressed experiments.Here, we tracked adult participants' motions they underwent ecologically valid conditioning a 3D virtual space.First, with motion tracking, revealed...