A5063482594- Nerve injury and regeneration
- Gastric Cancer Management and Outcomes
- Impact of Technology on Adolescents
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Surgical Simulation and Training
- COVID-19 and Mental Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Wireless Body Area Networks
- Child Development and Digital Technology
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Mental Health Research Topics
- Dental Implant Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Anatomy and Medical Technology
- Metastasis and carcinoma case studies
- Molecular Communication and Nanonetworks
- Pain Mechanisms and Treatments
- Photonic Crystals and Applications
- Copper Interconnects and Reliability
- Radiomics and Machine Learning in Medical Imaging
Saiseikai Niigata Daini Hospital
2025
KDDI Research (Japan)
2021-2024
Gunma University
2020-2024
University of Shizuoka
2023-2024
Hakodate Central General Hospital
2024
Doshisha University
2024
Kyorin University
2024
Toshiba (Japan)
2014-2024
University of Toyama
2015-2023
Saiseikai Ibaraki Hospital
2023
Rubrospinal neurons (RSNs) undergo a marked atrophy in the second week after cervical axotomy. This delayed is accompanied by decline expression of regeneration-associated genes such as GAP-43 and Talpha1-tubulin, which are initially elevated injury. These responses may reflect deficiency trophic support axotomized RSNs. To test this hypothesis, we first analyzed mRNAs encoding trk family neurotrophin receptors. In situ hybridization revealed full-length trkB receptors virtually all RSNs,...
Internet gaming disorder (IGD) and problematic internet use (PIU) are becoming increasingly detrimental to modern society, with serious consequences for daily functioning. IGD PIU may be exacerbated by lifestyle changes imposed the coronavirus 2019 (COVID-19) pandemic. This study investigated in during pandemic risk factors them. is a part of larger online smartphone Japan, originally planned 2019, expanded August 2020 include impact COVID-19. 51,246 adults completed an survey (August 2020),...
Scientific interest to find a treatment for spinal cord injuries has led the development of numerous experimental strategies promote axonal regeneration across injury site. Although these have been developed in acute paradigms and hold promise individuals with future, little is known about their applicability vast majority paralyzed whose occurred long ago who are considered chronic injury. Some studies shown that effectiveness approaches diminishes dramatically within weeks after Here we...
Conductive polymers (CPs) are organic materials that hold great promise for biomedicine. Potential applications include in vitro or implantable electrodes excitable cell recording and stimulation conductive scaffolds support tissue engineering. In this study, we demonstrate the utility of electroactive CP polypyrrole (PPy) containing anionic dopant dodecylbenzenesulfonate (DBS) to differentiate novel clinically relevant human neural stem cells (hNSCs). Electrical PPy(DBS) induced hNSCs...
Sense of agency (SoA) is the perceived control over one's actions and their consequences, through this one feels responsible for consequent outcomes in world. We analyze far-reaching implications a two-pronged knowledge on SoA its impact human-AI interactions. argue that although there are interesting research efforts an AI to inherently possess SoA, they still sparse, constrained scope present unclear immediate benefit design AI-enabled systems. also how human affected by sense presents...
Abstract Motoneurons of the adult survive after axotomy even though they are deprived putative target derived trophic factors. Alternative sources support may substitute. In this study we test hypothesis that immediate environment motoneuronal cell body or itself increases production factors axonal injury. Using in situ hybridization (ISH) and reverse transcription–polymerase chain reaction (RT‐PCR), report axotomy, rat facial motoneurons increase expression mRNA for brainderived...
Solid nanotubes comprising α-Fe2O3 nanoparticles were prepared from iron-storage protein ferritin. Their structure, magnetic properties, and photocatalytic activities characterized. The initial ferritin nanotube precursors fabricated using alternating layer-by-layer depositions of poly-l-arginine (PLA) into a track-etched polycarbonate membrane (pore diameter, 400 nm) with subsequent dissolution the template. obtained uniform cylinders (PLA/ferritin)3 (outer 410 ± 14 calcinated at 500 °C...
The prediction of anatomical structures within the surgical field by artificial intelligence (AI) is expected to support surgeons' experience and cognitive skills. We aimed develop a deep-learning model automatically segment loose connective tissue fibers (LCTFs) that define safe dissection plane. annotation was performed on video frames capturing robot-assisted gastrectomy trained surgeons. A based U-net developed output segmentation results. Twenty randomly sampled were provided evaluate...
Signals sent through CD40 play crucial roles in B cell differentiation, including blocking apoptosis of germinal center cells. In this study, using a murine WEHI-231 line that undergoes by the cross-linking surface Ag receptors (sIgM), we have demonstrated signalings are linked to induction Bcl-xL, Cdk4, and Cdk6 proteins whose expression was significantly suppressed apoptotic signal sIgM. Mutational analyses revealed domain human required for cells coincides with Bcl-xL induction. sIgM...
Abstract Background Artificial intelligence (AI) has the potential to enhance surgical practice by predicting anatomical structures within field, thereby supporting surgeons' experiences and cognitive skills. Preserving utilising nerves as critical guiding is paramount in rectal cancer surgery. Hence, we developed a deep learning model based on U-Net automatically segment nerves. Methods The performance was evaluated using 60 randomly selected frames, Dice Intersection over Union (IoU)...
Abstract We aimed to develop an AI model that recognizes and displays loose connective tissue as a dissectable layer in real-time during gastrointestinal surgery evaluate its performance, including feasibility for clinical application. Training data were created under the supervision of surgeons. Test images videos randomly sampled performance was evaluated visually by 10 external The mean Dice coefficient 50 0.46. could detect at least 75% 91.8% (459/500 responses). False positives found...
While transcatheter arterial chemoembolization (TACE) is a treatment option for patients with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma, it associated physical and psychological pain, concerns regarding its effect on quality of life (QOL). In December 2020, we introduced radiology nurse-led preoperative visits to undergoing TACE. This study aimed examine QOL improvement following visit. Among scheduled undergo TACE 48 received visit 22 did not (control group). We...
Abstract Injury to the spinal cord or peripheral nerves can lead development of allodynia due loss inhibitory tone involved in sensory function. The potential intraspinal transplants GABAergic cells restore and thus decrease pain behaviors a rat model neuropathic was investigated. Allodynia left hind paw induced rats by unilateral L5– 6 nerve root ligation. Mechanical sensitivity assessed using von Frey filaments. Postinjury, transgenic fetal green fluorescent protein mouse human neural...
Abstract Introduction Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significant neuronal loss and functional deficits. The use cell-based therapies recover injured offers new hope. In current study, we employed human neural stem cells (hNSCs) isolated from subventricular zone (SVZ), directed their differentiation into GABAergic neurons followed by transplantation ischemic brain. Methods Pre-differentiated neurons, undifferentiated...
The short version of the smartphone addiction scale (SAS-SV) is widely used to measure problematic use (PSU). This study examined validity and reliability SAS-SV among Japanese adults, as well cross-sectional longitudinal associations with relevant mental health traits problems.Datasets from a larger project on were conduct two studies. Participants adults aged over 20 years who carried smartphone.Study 1 (n = 99,156) showed acceptable internal consistency structural bifactor model three...
Abstract This report describes the synthesis and enzyme activities of multilayered protein nanotubes with an α‐glucosidase (αGluD) interior surface. The were prepared by using alternating layer‐by‐layer (LbL) assembly human serum albumin (HSA) oppositely charged poly‐ L ‐arginine (PLA) into a track‐etched polycarbonate (PC) membrane (pore size=400 nm) followed addition αGluD as last layer wall. Subsequent dissolution PC template yielded (PLA/HSA) 2 PLA/αGluD nanotubes. SEM measurements...