A5005385777- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Fatty Acid Research and Health
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Diet and metabolism studies
- MicroRNA in disease regulation
- Spinal Dysraphism and Malformations
- Sleep and Wakefulness Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Lung Cancer Research Studies
- Hair Growth and Disorders
- Reproductive System and Pregnancy
Université de Montréal
2014-2024
Université de Sherbrooke
2023-2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2023-2024
Centre Hospitalier Universitaire de Sherbrooke
2023
Mercy St. Vincent Medical Center
2009
Mercy Medical Center
2009
University of Toronto
2004-2007
Occupational Cancer Research Centre
2007
Hospital for Sick Children
2005
SickKids Foundation
2005
Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental therapeutic tool. Typical EE paradigms are multifactorial, incorporating elements of physical exercise, environmental complexity, social interactions stress, however the specific contributions these variables have not been separable using conventional housing paradigms. Here, we evaluated impacts individual adult hippocampal neurogenesis by a novel "Alternating EE" paradigm. For 4...
Adult forebrain neurogenesis is dynamically regulated. Multiple families of niche-derived cues have been implicated in this regulation, but the precise roles key intracellular signaling pathways remain vaguely defined. Here, we show that mammalian target rapamycin (mTOR) pivotal determining proliferation versus quiescence adult neural stem cell (NSC) niche. Within niche, mTOR complex-1 (mTORC1) activation displays stage specificity, occurring transiently amplifying (TA) progenitor cells not...
Axotomized motoneurons regenerate their axons regardless of whether axotomy occurs proximally or distally from cell bodies. In contrast, regeneration rubrospinal into peripheral nerve grafts has been detected after cervical but not thoracic injury the tract. By using in situ hybridization (ISH) combined with reliable retrograde tracing methods, we compared regeneration-associated gene expression proximal and distal spinal versus neurons. Regardless they were axotomized at iliac crest...
Abstract Alzheimer’s disease (AD) affects cognitive modalities that are known to be regulated by adult neurogenesis, such as hippocampal‐ and olfactory‐dependent learning memory. However, the relationship between AD‐associated pathologies alterations in neurogenesis has remained contentious. In present study, we performed a detailed investigation of triple transgenic (3xTg) mouse model AD, unique generates both amyloid plaques neurofibrillary tangles, hallmark AD. neurogenic niches brain,...
The adult mammalian spinal cord has limited regenerative capacity in settings such as injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell potential, undergoing proliferation multi-lineage differentiation following experimental SCI. To determine whether reactive are a realistic endogenous population to target order promote repair, we assessed spatiotemporal dynamics of for up 35 days three models...
Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We shown previously that endogenous stem cell is confined to ependymal in adult which could be targeted non-invasive SCI therapy. However, are an understudied population. Taking advantage transgenic lines, we characterize appearance and during development. show vitro contained within these by birth. Moreover, juvenile cultures generate more neurospheres oligodendrocytes than ones. Interestingly, vivo...
Abstract The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning memory. Of these, abnormalities are the least understood. Here, we investigate role Stearoyl-CoA desaturase (SCD), a crucial regulator fatty acid desaturation, AD pathogenesis. We show that inhibiting brain SCD activity for 1-month 3xTg mouse model alters core AD-related transcriptomic pathways hippocampus, it concomitantly restores...
Abstract Voluntary wheel‐running induces a rapid increase in proliferation and neurogenesis by neural precursors present the adult rodent hippocampus. In contrast, responses of hippocampal other central nervous system following longer periods voluntary physical activity are unclear an issue potential relevance to rehabilitation programs. We investigated effects prolonged, 6‐week paradigm on CD1 mouse hippocampus forebrain. Examination 6 weeks running revealed two three times as many newly...
Late-onset sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but its origin remains poorly understood. The Bmi1/Ring1 protein complex maintains transcriptional repression developmental genes through histone H2A mono-ubiquitination, and Bmi1 deficiency in mice results growth retardation, progeria, neurodegeneration. Here, we demonstrate that BMI1 silenced AD brains, not those with early-onset familial AD, frontotemporal or Lewy body dementia. expression was also...
Alterations in the gut microbiome constitute a feature of aging and therefore represent therapeutic target for aging-related diseases. In this study, we investigated impact ketogenic interventions on mice genetically predisposed to Alzheimer disease (AD). AD exhibited several microbial alterations, notably increased levels Bifidobacterium decreased Bacteroidetes. Ketogenic interventions, either medium-chain triglyceride-enriched diet (MCT) or carbohydrate-free high-fat (CFHF), administered 1...
Rationale: Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is potential target for neurodegenerative diseases, such as Alzheimer's disease (AD). Increasing evidence shows impairment of adult neurogenesis by perturbed lipid metabolism predisposes patients AD. However, it remains unknown what causes aberrant expression Mgll in AD and how Mgll-regulated impacts neurogenesis, thus predisposing...
Development of the spinal cord requires dynamic and tightly controlled expression numerous transcription factors. Forkhead Box protein J1 (FoxJ1) is a factor involved in ciliogenesis specifically expressed ependymal cells (ECs) adult central nervous system. However, using FoxJ1 fate-mapping mouse lines, we observed that also transiently by progenitors other neural subtypes during development. Moreover, knock-in line, discovered essential for embryonic to follow normal developmental...
The ventricular-subventricular zone (V-SVZ) is the principal neurogenic niche in adult mammalian forebrain. Neural stem/progenitor cell (NSPC) activity within V-SVZ controlled by numerous of extrinsic factors, whose downstream effects on NSPC proliferation, survival and differentiation are transduced via a limited number intracellular signaling pathways. Here, we investigated relationship between age-related changes output pathways epidermal growth factor receptor (EGFR), major regulator...