A5000336401- Nutritional Studies and Diet
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Genetic Associations and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Gout, Hyperuricemia, Uric Acid
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Birth, Development, and Health
- Sleep and related disorders
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Physical Activity and Health
- Growth Hormone and Insulin-like Growth Factors
- Gastroesophageal reflux and treatments
- Sodium Intake and Health
- Folate and B Vitamins Research
- Ovarian function and disorders
- Child Nutrition and Feeding Issues
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Dysphagia Assessment and Management
Nagoya University
2014-2025
Okayama University of Science
2022
Gifu University
2014-2020
Jichi Medical University
1982-2015
Kinan Hospital
2011
Gifu University Hospital
2007
Material Sciences (United States)
2005
Wakayama Prefectural Tanabe High School
2002
Japanese Red Cross Kochi Hospital
1998
Tokyo Gakugei University
1985
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, dysfunctional variants of ABCG2, urate exporter gene also known as BCRP, are revealed to be major cause gout/hyperuricemia. Here, we compared the influence ABCG2 dysfunction on serum uric acid (SUA) levels with other risk factors in cohort 5,005 Japanese participants. was observed 53.3% population investigated and its population-attributable percent (PAR%) for hyperuricemia 29.2%, much higher...
Although several experimental studies suggested that soy isoflavone intake inhibits the growth of stomach cancer, previous epidemiological have observed inconsistent results. We evaluated associations or with cancer incidence after considering lifestyle factors, including salt intake, in a population-based prospective cohort study Japan. Subjects were 14,219 men and 16,573 women aged 35 years older September 1992. Soy intakes, assessed validated food-frequency questionnaire, controlled for...
Compared with the abundant data from Western countries, evidence regarding meat consumption and colorectal cancer is limited in Japanese population. We evaluated risk relation to a population‐based prospective cohort study Japan. Participants were 13 957 men 16 374 women aged ≥35 years September 1992. Meat intake, assessed validated food frequency questionnaire, was controlled for total energy intake. The incidence of confirmed through regional registries histological identification...
The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene-environment interactions lifestyle-related diseases, including cancers, among the Japanese. This report describes design and baseline profile of participants.The participants J-MICC Study were individuals aged 35 69 years enrolled from respondents announcements specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at centers,...
Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that behavior-related genetic variants are directly associated with cancer, independent behavior, mainly in European populations. A recent genome-wide association study Japan identified five loci number cigarettes smoked per day. This aimed to evaluate whether these cancer or indirectly through changing behavior. Here, we conducted a case-control (1427 cases and 5595 controls) prospective...
<p>Supplementary Table S1-S14</p>
<p>Supplementary File (List of the contributors to J-MICC Study)</p>
It has been hypothesized that disruption of circadian rhythms affects human health. Shift work and sleep deprivation are thought to disrupt the normal light–dark cycle, although due shiftwork may be dependent on deprivation. Both conditions have suggested associated with an increased risk cardiometabolic disorders. Non-photic environmental factors, such as timing eating, also regulate rhythm thus, effects health, but evidence from studies is scarce. Oxidative stress a factor Some laboratory...
It has been hypothesized that alteration of hormone systems is involved in the carcinogenesis acrylamide. The aim present study was to examine cross-sectional associations between dietary acrylamide intake and sex levels premenopausal Japanese women.Study subjects were 393 women who had regular menstrual cycles less than 40 days long. Acrylamide assessed with a food-frequency questionnaire based on concentration reported from analyses foods. We measured plasma concentrations estradiol,...
Several case-control studies have reported that patients with diabetes mellitus (DM) had a higher prevalence of Helicobacter pylori infection than those without DM, but these findings remain equivocal. Additionally, there are few examining associations between East Asian CagA-positive H. and DM. This cross-sectional study aimed to investigate whether was possible risk factor for DM in general Japanese population. The included 5165 subjects (1467 men, 3698 women) aged 35-69 years from the...
We aimed to investigate whether coffee, green tea, and caffeine intake are associated with liver cancer risk, using data of a prospective cohort study. This study included 30,824 participants (14,240 men 16,584 women) aged 35 years or older in the Takayama study, which was launched on September 1, 1992. The consumption frequencies coffee tea were assessed self-administered questionnaire. Caffeine estimated from caffeine-containing beverages foods their content per serving. incidence...
Abstract Background Mental health has become a major public issue worldwide. Biological and epidemiological studies suggest diet role in the prevention or cure of mental disorders. However, further research is required to elucidate relationship between health. This study aimed investigate associations dietary intake nutrients (macronutrients, vitamins, calcium, fatty acids) food groups (fish, meat chicken, dairy products, vegetables) among middle-aged Japanese cross-sectional prospective...
The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary assessed using net-endogenous-acid-production (NEAP) score that is closely correlated with rate renal net excretion. MetS diagnosed according to Joint Interim Statement Criteria 2009 body-mass index...
Dysfunctional missense variant of organic anion transporter 10 ( OAT10 / SLC22A13 ), rs117371763 (c.1129C&gt;T; p.R377C), is associated with a lower susceptibility to gout. urate transporter; however, its physiological role in handling remains unclear. We hypothesized that could be renal re-absorber will new molecular target urate-lowering therapy like 1 (URAT1, physiologically-important well-known re-absorber) and aimed examine the effect dysfunction on handling. For this purpose, we...
Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and evaluate its ability non-European populations. We genome-wide blood pressure Japanese population examined the associations between this hypertension prevalence.We performed cross-sectional study 11 252 individuals who participated J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary...
Background . Interleukin-6 (IL-6) is a multifunctional cytokine produced by many types of cells. Inflammation plays key role in the pathogenesis atherosclerosis that an underlying cause coronary heart disease (CHD). Since 1990s, some studies have shown association between H. pylori infection and CHD, which may be mediated inflammation. Therefore, this study aimed to evaluate serum anti- IgG levels IL-6 -infected adults. Methods. We enrolled 158 subjects who visited clinic located urban area...