A5101494135- Retinal Diseases and Treatments
- Gout, Hyperuricemia, Uric Acid
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Oral microbiology and periodontitis research
- Glaucoma and retinal disorders
- Alcohol Consumption and Health Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Nutritional Studies and Diet
- Renin-Angiotensin System Studies
- Case Reports on Hematomas
- Chronic Kidney Disease and Diabetes
- Retinal and Macular Surgery
- Obesity, Physical Activity, Diet
- Coffee research and impacts
- Colorectal Cancer Screening and Detection
- Probiotics and Fermented Foods
- Enzyme Production and Characterization
- Metabolism and Genetic Disorders
- Streptococcal Infections and Treatments
National Defense Medical College
2013-2024
Weatherford College
2020
Data Management (Italy)
2018
Nagoya University
2014
Tokyo University of Pharmacy and Life Sciences
2014
Jikei University School of Medicine
2014
National Defense Medical College Hospital
2013
Fujita Health University
2007
Toranomon Hospital
1998
Juntendo University
1998
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into 'overproduction type' and/or 'underexcretion based solely on renal excretion, without considering an extra-renal pathway. Here we show that decreased excretion caused by ABCG2 common mechanism hyperuricemia. Clinical parameters, including urinary are examined in 644 male outpatients with Paradoxically, export significantly...
Gout based on hyperuricemia is a common disease with genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in gout-susceptibility locus chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 high-capacity urate secretion transporter. Sequencing the gene 90 patients revealed several nonfunctional mutations, including Q126X. Quantitative trait analysis...
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and subtypes remains unclear. Here, we first performed GWAS clinically defined only. Methods A conducted with 945 patients 1213 controls Japanese male population, followed replication study 1048 1334 controls....
Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 major cause renal overload (ROL) hyperuricemia, but its involvement in underexcretion (RUE) most prevalent subtype, not clearly explained so far. In this study, association analysis with 644 hyperuricemia patients and 1,623 controls male Japanese revealed significantly increased risk RUE as well overall ROL according to severity impairment. caused induced even if was...
Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether dysfunction ABCG2, high-capacity urate transporter regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset data and 1,887 controls were genotyped, ABCG2 functions are estimated by its genotype combination determined. The was 6.5 years earlier severe than normal function (P = 6.14 × 10(-3)). Patients...
<h3>Aims</h3> To evaluate the efficacy of measuring subfoveal choroidal thickness in monitoring uveitis activity before and after treatment with infliximab patients Behçet9s disease (BD)-associated uveitis. <h3>Methods</h3> Thirteen BD (23 eyes) were selected for this retrospective observational case study. Subfoveal was measured during active remission phases by enhanced depth imaging–spectral domain optical coherence tomography (EDI-OCT). In five (10 eyes), assessed at weeks 0, 2, 6 14...
Macrophages are involved in low-grade inflammation diabetes, and play pathogenic roles proliferative diabetic retinopathy (PDR) by producing proinflammatory cytokines. T cells as well other also activated cytokines, infiltration into the vitreous of patients with PDR has been shown. In this study, we measured helper (Th) cell-related cytokines to define characteristics Th-mediated immune responses associated PDR. The study group consisted 25 type 2 (25 eyes) control 27 epiretinal membrane...
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, dysfunctional variants of ABCG2, urate exporter gene also known as BCRP, are revealed to be major cause gout/hyperuricemia. Here, we compared the influence ABCG2 dysfunction on serum uric acid (SUA) levels with other risk factors in cohort 5,005 Japanese participants. was observed 53.3% population investigated and its population-attributable percent (PAR%) for hyperuricemia 29.2%, much higher...
Background —Physical activity decreases the risk of coronary heart disease (CHD), but its effects on factors require further exploration. Methods and Results —The study included 3331 adult Japanese men in whom health benefits, especially CHD factors, were compared among those who sedentary engaged continuous physical 30 minutes or more per day for 1, 2 ≥3 days week. Significantly higher HDL cholesterol values; lower triceps, scapula, iliac subcutaneous fat thickness; smoking rates noted all...
Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels. From viewpoint of urate handling in humans, gout patients can be divided into those with renal overload (ROL) intestinal underexcretion, and underexcretion (RUE) gout. Recent genome-wide association studies (GWAS) revealed an between SUA variant human monocarboxylate transporter 9 (MCT9/SLC16A9) gene. Although the function MCT9 remains unclear, mostly excreted via intestine kidney where...
Adult atopic dermatitis (AD) in Japan has become a significant social problem, with as many one-third of adult patients severe AD absenting themselves from work or classes due to aggravation the disease. Reports such have increasingly common recent years. Despite pressing need for epidemiological studies clarify prevalence and distribution determine its aetiology, no previous research been carried out on within population Japan.To Japan, using U.K. Working Party's diagnostic criteria.The...
The relation between obesity and adenomatous polyps of the sigmoid colon was investigated in male self‐defense officials who received a retirement health examination at three hospitals Self‐Defense Forces Japan January 1991 December 1992. Body mass index (BMI) waist‐hip circumference ratio (WHR) were used as indices obesity. A total 228 adenoma cases 1484 controls with normal sigmoidoscopy identified 2228 men: having small adenomas (<5 mm diameter) those large (5 or greater) numbered 115...
Animal experiments have shown a hypocholesterolemic effect of green tea extracts. Only few epidemiological studies addressed the relation between consumption and serum total cholesterol (TC) low density lipoprotein (LDL-C). This paper examined to lipids lipoproteins in 2,062 male self-defense officials Japan, aged 49-55 years, who received preretirement health examination at three hospitals Self-Defense Forces 1991-1992. A self-administered questionnaire queried limited number other dietary...
1. The role of endogenous prostaglandins in the antihypertensive mechanism angiotensin converting enzyme inhibitor, captopril, was investigated. 2. An unequivocal reduction blood pressure and significant increase plasma renin activity urinary prostaglandin E excretion were found after captopril administration. 3. changes pressure, induced by reversed inhibition synthesis indomethacin. However, responses low hypertension different from those normal hypertension. 4. In hypertensive patients...
Context: Dental caries are an infectious oral bacterial disease caused by cariogenic streptococci. These streptococci inhabit dental biofilms which comprise insoluble glucans.Objective: To prevent caries, nisin, a suitable agent active against Gram-positive bacteria, was examined in vitro for its ability to suppress glucan-biofilm synthesis streptococci.Materials and methods: investigate typical streptococcus, Streptococcus mutans 10449, the naked form of nisin loaded onto 96-well microplate...
Urate transporter 1 (URAT1/SLC22A12), a urate gene, is causative gene for renal hypouricemia type 1. Among several reported nonsynonymous URAT1 variants, R90H (rs121907896) and W258X (rs121907892) are frequent mutations hypouricemia. However, no case-control study has evaluated the relationship between gout these two variants. Additionally, effect size of variants on serum uric acid (SUA) levels remains to be clarified. Here, 1,993 primary patients 4,902 health examination participants...
Abstract Purpose To evaluate real‐world evidence for young Japanese patients with rhegmatogenous retinal detachment ( RRD ) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group. Methods This was a multicentre retrospective study of medical records 562 (384 males 178 females; mean age: 33.0 ± 11.8 years) who had been diagnosed underwent participating centres during period between April 2013 August 2016. Results The selected surgeries...
AbstractBackground: Risk factors for gallstones are not fully understood, especially in men. Obesity and other risk gallstone disease were investigated Japanese men based on gallbladder ultrasonography. Methods: Forty-one with gallstones, 31 postcholecystectomy state, 2044 a normal identified among 2228 aged 49-55 years who received retirement health examination at three hospitals of the Japan Self-Defense Forces between 1991 1992. Glucose tolerance was determined 75-g oral glucose test....