A5047910903- Alcohol Consumption and Health Effects
- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Connexins and lens biology
- Head and Neck Cancer Studies
- High Altitude and Hypoxia
- Genetic factors in colorectal cancer
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- Social Robot Interaction and HRI
- BRCA gene mutations in cancer
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- RNA and protein synthesis mechanisms
- Metabolism, Diabetes, and Cancer
Futaba (Japan)
2025
Shionogi (Japan)
2025
Nagoya City University
2009-2024
Aichi University of Education
2022-2024
Kobe University Hospital
2023
Toyohashi Municipal Hospital
2023
Tokyo Dental College
2018-2023
Tokyo Metropolitan Ohtsuka Hospital
2021-2022
Mizuho (Japan)
2019-2022
Tsurumi University
2022
BackgroundSevere coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment baricitinib, a Janus kinase inhibitor, plus remdesivir are not known.MethodsWe conducted double-blind, randomized, placebo-controlled trial evaluating baricitinib in hospitalized adults Covid-19. All the patients received (≤10 days) and either (≤14 or placebo (control). primary outcome was time to recovery. key secondary clinical status at day 15.ResultsA...
Human studies have shown loss of diversity the gut microbiome following hematopoietic stem cell transplantation (HSCT) in association with significant injury caused by preparative regimen. Prolonged antibiotic use worsens and increases risk complications such as graft-versus-host disease (GVHD). Our data support hypothesis that intestinal commensals produce short-chain fatty acids (SCFAs) may increase dysbiosis. Here, we report an extensive longitudinal examination changes luminal SCFAs...
Abstract Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of biology. Here, we examined underlying changes in biology mosquitoes associated with dehydration. Specifically, show increases blood feeding northern house mosquito, Culex pipiens , which was result both higher activity and a greater tendency land host. Similar observations were noted for Aedes aegypti Anopheles quadrimaculatus...
PAS domains, which have been identified in over 1100 proteins from all three kingdoms of life, convert various input stimuli into signals that propagate to downstream components by modifying protein-protein interactions. One such protein is the Escherichia coli redox sensor, Ec DOS, a phosphodiesterase degrades cyclic adenosine monophosphate redox-dependent manner. Here we report crystal structures heme domain DOS both inactive Fe(3+) and active Fe(2+) forms at 1.32 1.9 A resolution,...
Environmental exposures and/or genetic background in Japanese population, which might contribute to the relatively low breast cancer incidence rates Japan, have not been clarified detail. Folate plays an essential role DNA methylation and synthesis, thus may be involved development of cancer. Functional polymorphisms genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), (MTRR A66G) thymidylate (TS), influence folate...
Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment in development of lifestyle-related diseases, especially cancer, Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched 2005.Methods: We initiated a cross-sectional study examine associations genotypes with lifestyle clinical factors, as assessed by questionnaires medical examinations. The 4519 subjects were selected among...
Although several studies have investigated the association between ABO blood type and risk of gastric cancer (GC), atrophic gastritis (AG), Helicobacter pylori (HP) infection, no study has these associations by using genotype.We conducted a case-control in 703 patients with GC 1,465 noncancer patients. We also cross-sectional 1,406 controls, who were examined for pepsinogens anti-HP IgG antibody levels serum. genotype was determined from single nucleotide polymorphisms gene. used rs8176719...
The impact of alcohol on the risk stomach cancer is controversial. Although aldehyde dehydrogenase 2 ( ALDH2 ) Glu504Lys (rs671) polymorphism has a strong effect acetaldehyde metabolism, little known about its when combined with drinking. This case-control study included total 697 incident case subjects and 1372 non-cancer control who visited Aichi Cancer Center between 2001 2005. We estimated odds ratios (OR) 95% confidence intervals (CI) for genotypes consumption using logistic regression...
A protein containing a heme-binding PAS (PAS is from the names in which imperfect repeat sequences were first recognized: PER, ARNT, andSIM) domain Escherichia coli has been implied direct oxygen sensor (Ec DOS) enzyme. In present study, we isolated cDNA for Ec DOS full-length protein, expressed it E. coli, and examined its structure-function relationships time. EcDOS was found to be tetrameric obtained as 6-coordinate low spin ferric heme complex. Its α-helix content calculated 53% by CD...
Several studies have investigated a possible association between the ABO blood group and risk of pancreatic cancer (PC), but this has not been fully evaluated in Asian populations. The present study aimed to assess impact genotype‐derived types, particularly alleles, on PC Japanese population. We conducted case–control using 185 1465 control patients who visited Aichi Cancer Center Nagoya, Japan. Using rs8176719 as marker for O allele, rs8176746 rs8176747 B all participants’ two alleles were...
Some Japanese exhibit facial flushing after drinking alcohol. Facial was considered to be caused by acetaldehydemia. The concentration of blood acetaldehyde concerned with the catalytic activity dehydrogenase (ALDH). Acetaldehyde (ALDH)-2 polymorphism (rs671, Glu504Lys) known associated upper aerodigestive tract (UAT) cancer due modulation ALDH2 enzyme activity. It remains controversial whether is useful in predicting UAT risk as a surrogate marker polymorphism. We conducted case-control...
When ectotherms are exposed to low temperatures, they enter a cold-induced coma (chill coma) that prevents resource acquisition, mating, oviposition, and escape from predation. There is substantial variation in time taken recover chill both within among species, this correlated with habitat temperatures such insects cold environments more quickly. This suggests an adaptive response, but the mechanisms underlying recovery times unknown, making it difficult decisively test hypotheses. We use...
Zebra mussel, Dreissena polymorpha, in the Great Lakes is being monitored as a bio-indicator organism for environmental health effects by National Oceanic and Atmospheric Administration's Mussel Watch program. In order to monitor of industrial pollution on ecosystem, invasive zebra mussels were collected from four stations-three inner harbor sites (LMMB4, LMMB1, LMMB) Milwaukee Estuary, one reference site (LMMB5) Lake Michigan, Wisconsin. Nuclear magnetic resonance (NMR)-based metabolomics...
The roles of robots in the real world have become more diverse depending on their bodily properties. In this study, we aim to determine that androids, whose properties resemble humans, could serve world. Selling and purchasing are common human activities. Therefore, proposed use an android as a salesperson with cognitive affective strategies utilizing advantages online- counter- selling methods. We conducted field study investigate whether androids sell goods department store. As result, our...
An Aerodyne quadrupole aerosol mass spectrometer (AMS) was deployed in China the summer of 2006. The measurements were made Pearl River Delta region July 2006 (PRD campaign) and also Beijing August–September (CAREBEIJING campaign). AMS successfully measured size-resolved chemical composition submicron non-refractory (vaporized at 600°C vacuum) with a time resolution 10 min, although some quantification issues have been identified. We observed extremely large signals m/z 39 ( K + ) 41 (41K ),...
Abstract Alcohol intake is positively associated with the risk of upper aerodigestive tract (UAT) cancer. The genes that encode alcohol-metabolizing enzymes, primarily alcohol dehydrogenases (ADH) and aldehyde (ALDH), are polymorphic. In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) ADH1C (rs698 rs1693482), UAT cancer have been observed, despite strong linkage disequilibrium among them. Moreover, was significantly rs1573496 ADH7, not rs1984362 ADH4. However,...
A recent whole-genome association study identified a strong between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate association, further explore environmental factors possibly interacting with PSCA 708 incident cases age-sex matched controls. The Helicobacter pylori infection was also examined. We found that rs2294008 rs2976392, which were strongly linked each other (D' = 1.00), significantly associated Per...
Abstract Background Oral hygiene is attracting increasing attention as a potential risk factor for cancers. To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, authors conducted large‐scale case‐control study. Methods A total of 856 UADT cancer case participants 2696 age‐ sex‐matched control subjects without were included. Edentulous or with unknown number remaining teeth excluded. Associations assessed by odds ratios 95% confidence...
Gastric cancer incidence and mortality have been decreasing in Japan. These decreases are likely due to a decrease prevalence of Helicobacter pylori infection. Our aim was characterize the trends H. infection focused on birth‐year. We carried out cross‐sectional study that included 4285 subjects who were born from 1926 1989. defined by serum antibody titer. Individuals having those with negative titer positive pepsinogen test as high‐risk individuals for gastric cancer. estimated birth‐year...
The Tsuruoka Metabolomics Cohort Study included subjects aged 35-74 years from participants in annual health check-up programs Tsuruoka, Japan. gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 had fundus photographs sufficient quality, AMD present 12.3% 10.3% men women, respectively. In men, higher levels high-density lipoprotein cholesterol lower triglycerides were associated...
Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption European populations, no such study yet been conducted an Asian population. Here, we a GWAS to identify common variations that affected Japanese population 11,261 participants recruited as part Japan Multi-Institutional Collaborative Cohort (J-MICC) study....