Emily C. Jennings
A5091892741- Insect behavior and control techniques
- Forensic Entomology and Diptera Studies
- Insect symbiosis and bacterial influences
- Diptera species taxonomy and behavior
- Trypanosoma species research and implications
- Insect-Plant Interactions and Control
- Subterranean biodiversity and taxonomy
- Freshwater macroinvertebrate diversity and ecology
- Environmental DNA in Biodiversity Studies
- Insects and Parasite Interactions
- Insect and Arachnid Ecology and Behavior
- Cancer Immunotherapy and Biomarkers
- Agricultural pest management studies
- Plant Parasitism and Resistance
- Insect Resistance and Genetics
- Colorectal and Anal Carcinomas
- Insect Utilization and Effects
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Physiological and biochemical adaptations
- Entomopathogenic Microorganisms in Pest Control
- Hemiptera Insect Studies
- Plant and animal studies
- Viral Infections and Vectors
- Cancer Genomics and Diagnostics
AstraZeneca (United States)
2022-2024
University of Cincinnati
2015-2023
University of Cincinnati Medical Center
2018
Art Academy of Cincinnati
2015
M.J.P. Rohilkhand University
1904
The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability adapt variety solanaceaeous plants and variable climates during its global invasion, and, notably, rapidly evolve insecticide resistance. To examine evidence rapid evolutionary change, understand genetic basis herbivory resistance, we tested for structural functional genomic changes relative other arthropod species using genome sequencing, transcriptomics, community...
Abstract The bed bug, Cimex lectularius , has re-established itself as a ubiquitous human ectoparasite throughout much of the world during past two decades. This global resurgence is likely linked to increased international travel and commerce in addition widespread insecticide resistance. Analyses C. sequenced genome (650 Mb) 14,220 predicted protein-coding genes provide comprehensive representation that are traumatic insemination, reduced chemosensory repertoire related obligate...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Abstract Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of biology. Here, we examined underlying changes in biology mosquitoes associated with dehydration. Specifically, show increases blood feeding northern house mosquito, Culex pipiens , which was result both higher activity and a greater tendency land host. Similar observations were noted for Aedes aegypti Anopheles quadrimaculatus...
Abstract Background The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on wide array of food, fiber, ornamental crops. underlying genetic mechanisms the processes governing thrips biology, feeding behaviors, ecology, insecticide resistance are largely unknown. To address this gap, we present F. draft genome assembly official gene set. Results We report first sequence for any member insect order Thysanoptera. Benchmarking...
Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. distinguished from other Diptera by unique adaptations, including lactation birthing live young (obligate viviparity), a vertebrate blood-specific diet both sexes, obligate bacterial symbiosis. This work describes comparative analysis six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, austeni), Palpalis palpalis, fuscipes), Fusca...
Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range scientific studies from ecology evolution to developmental genetics hydrodynamics fluid locomotion. However, lack representative strider genome hinders our ability more thoroughly investigate molecular mechanisms underlying processes adaptation diversification within group. Here we report sequencing manual annotation...
Abstract Background The stable fly, Stomoxys calcitrans , is a major blood-feeding pest of livestock that has near worldwide distribution, causing an annual cost over $2 billion for control and product loss in the USA alone. Control these flies been limited to increased sanitary management practices insecticide application suppressing larval stages. Few genetic molecular resources are available help developing novel methods controlling flies. Results This study examines fly biology by...
Abstract Purpose: Tumoral programmed cell death ligand-1 (PD-L1) expression is common in human papillomavirus (HPV)–associated head and neck squamous carcinoma (HNSCC). We assessed whether a DNA vaccine targeting HPV-16/18 E6/E7 with IL12 adjuvant (MEDI0457) combined the PD-L1 inhibitor durvalumab could enhance HPV-specific T-cell response improve outcomes recurrent/metastatic HPV-16/18–associated HNSCC. Patients Methods: In this phase Ib/IIa study, immunotherapy-naïve patients ≥1 previous...
Phlebotomine sand flies are of global significance as important vectors human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites genus Leishmania , causative agents devastating diseases collectively termed leishmaniasis. More than 40 pathogenic species transmitted to humans by approximately 35 fly in 98 countries with hundreds millions people at risk around world. No approved efficacious vaccine exists for leishmaniasis available...
Live birth (viviparity) has arisen repeatedly and independently among animals. We sequenced the genome transcriptome of viviparous Pacific beetle-mimic cockroach performed comparative analyses with two other insect lineages, tsetse flies aphids, to unravel basis underlying transition viviparity in insects. identified pathways undergoing adaptive evolution for insects, involved urogenital remodeling, tracheal system, heart development, nutrient metabolism. Transcriptomic analysis revealed...
Abstract Background: MEDI1191 is an IT-administered lipid nanoparticle-formulated mRNA encoding IL-12. This phase 1, open-label study (NCT03946800) showed that in sequential (seq) or concurrent (conc) combination with IV D (anti-PD-L1) was safe and had preliminary antitumor activity pts advanced/metastatic solid tumors who progressed on SoC. Here we present updated analyses, including the first report of deep-seated lesions. Methods: In Part 1A (subcutaneous/cutaneous [SC/C] lesions),...
Abstract One critical aspect of an insect's ability to overwinter successfully is the effective management its water resources. Maintenance adequate levels during winter challenging because prevailing low relative humidity at that time year and short supply environmental not in form ice. These issues are further exacerbated for insects overwintering as pupae, comprising immobile stage unable move new microhabitats if conditions deteriorate. The present study compares balance attributes...
Abstract The tremendous diversity of Hymenoptera is commonly attributed to the evolution parasitoidism in last common ancestor parasitoid sawflies (Orussidae) and wasp-waisted (Apocrita). However, Apocrita Orussidae differ dramatically their species richness, indicating that diversification was promoted by additional traits. These traits have remained elusive due a paucity sawfly genome sequences, particular those sawflies. Here, we present comparative analyses draft genomes primarily...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
The flesh fly, Sarcophaga bullata, is a widely-used model for examining the physiology of insect diapause, development, stress tolerance, neurobiology, and host-parasitoid interactions. Flies in this taxon are implicated myiasis (larval infection vertebrates) feed on carrion, aspects that important forensic studies. Here we present genome S. along with developmental- reproduction-based RNA-Seq analyses. We predict 15,768 protein coding genes, identify orthology relation to closely related...
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need consider TLS heterogeneity multiple features such as size, composition, maturation status, when assessing their functional impact. With aim gaining insights into biology evaluating prognostic impact maturity in Non-Small Cell Lung Carcinoma (NSCLC), we developed a multiplex immunofluorescent...
Abstract Background The stable fly, Stomoxys calcitrans , is a major blood-feeding pest of livestock that has near worldwide distribution, causing an annual cost over $2 billion for control and product loss in the United States alone. Control these flies been limited to increased sanitary management practices insecticide application suppressing larval stages. Few genetic molecular resources are available help developing novel methods controlling flies. Results This study examines fly biology...
The vertical transmission of microbes from mother to offspring is critical the survival, development, and health animals. Invertebrate systems offer unique opportunities conduct studies on microbiome-development-reproduction dynamics since reproductive modes ranging oviparity multiple types viviparity are found in these One such invertebrate live-bearing cockroach,
Background: Tsetse flies (Glossina sp.) are the sole vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. distinguished from other Diptera by unique adaptations, including lactation birthing live young (obligate viviparity), a vertebrate blood specific diet both sexes obligate bacterial symbiosis. This work describes comparative analysis six Glossina genomes representing three sub-genera: Morsitans (G. morsitans (G.m. morsitans), G. pallidipes, austeni), Palpalis...
Abstract The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability adapt variety solanaceaeous plants and variable climates during its global invasion, and, notably, rapidly evolve insecticide resistance. To examine evidence rapid evolutionary change, understand genetic basis herbivory resistance, we tested for structural functional genomic changes relative other arthropod species using genome sequencing, transcriptomics,...
ABSTRACT Background The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on wide array of food, fiber ornamental crops. While there are numerous studies centered thrips biology, feeding behaviors, ecology, insecticide resistance, the underlying genetic mechanisms processes governing these areas research largely unknown. To address this gap, we present F. draft genome assembly official gene set. Results We report first sequence...
Insects provide an unparalleled opportunity to link genomic changes with the rise of novel phenotypes, given tremendous variation in numerous and complex adaptations displayed across group. Among these adaptations, live-birth has arisen repeatedly independently insects tree life, suggesting this is one most common types convergent evolution among animals. We sequenced genome transcriptome Pacific beetle-mimic cockroach, only truly viviparous performed comparative analyses including two other...