A5014144339- Trypanosoma species research and implications
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- RNA and protein synthesis mechanisms
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Animal Genetics and Reproduction
- Insect and Arachnid Ecology and Behavior
- CRISPR and Genetic Engineering
- Hemiptera Insect Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect-Plant Interactions and Control
- RNA regulation and disease
- Fish Ecology and Management Studies
- Plant Molecular Biology Research
- RNA modifications and cancer
- Insects and Parasite Interactions
- PI3K/AKT/mTOR signaling in cancer
- Insect Utilization and Effects
- Genetics, Aging, and Longevity in Model Organisms
- Monoclonal and Polyclonal Antibodies Research
- Phytase and its Applications
National University of Northwestern Buenos Aires
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2024
Universidad Nacional de La Plata
2010-2023
Max Planck Institute for Biophysical Chemistry
1994-2005
Max Planck Society
1994-2005
Lunenfeld-Tanenbaum Research Institute
2004
Mount Sinai Hospital
2004
Max Planck Institute for Molecular Genetics
2004
Medizinische Hochschule Hannover
2004
Universidade Estadual de Londrina
2003
mRNP remodeling events required for the transition of an mRNA from active translation to degradation are currently poorly understood. We identified protein factors potentially involved in this transition, which present mammalian P bodies, cytoplasmic foci enriched 5′ → 3′ degrading enzymes. demonstrate that human bodies contain cap-binding eIF4E and related factor eIF4E-transporter (eIF4E-T), suggesting novel roles these proteins targeting mRNAs degradation. Furthermore, fluorescence...
Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is major vector Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced genome R. prolixus, generated assembled sequences covering 95% (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed,...
The bloodsucking hemipteran Rhodnius prolixus is a vector of Chagas' disease, which affects 7–8 million people today in Latin America. In contrast to other hematophagous insects, the triatomine gut compartmentalized into three segments that perform different functions during blood digestion. Here we report analysis transcriptomes for each using pyrosequencing technology. Comparison transcript frequency digestive libraries with whole-body library was used evaluate expression levels. All...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Abstract We show a straightforward workflow combining homology search in Rhodnius prolixus genome sequence with cloning by rapid amplification of cDNA ends and mass spectrometry. have identified 32 genes their transcripts that encode number neuropeptide precursors leading to 194 putative peptides. validated spectrometry 82 those predicted neuropeptides the brain R. achieve first comprehensive genomic, transcriptomic neuropeptidomic analysis an insect disease vector. Comparisons available...
Andiperla morenensis n. sp. is described from the Perito Moreno Glacier, Santa Cruz Province, Argentina. The new species differs its only congener, A. willinki, Aubert, 1956 by tergum X produced into an acute lobe directed posteriorly and presence of a small epiproct. The18S rRNA COI gene sequence provided.
The floating head ( flh ) gene in zebrafish encodes a homeodomain protein, which is essential for notochord formation along the entire body axis. orthologs, termed Not genes, have been isolated from chick and Xenopus , but no mammalian ortholog has yet identified. Truncate tc an autosomal recessive mutation mouse that specifically disrupts development of caudal notochord. Here, we demonstrate truncate arose by gene. allele contains point homeobox changes conserved Phenylalanine residue helix...
Background Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed Gran Chaco, ecoregion that extends over Argentina, Paraguay, Bolivia and Brazil. The voltage-gated sodium channel target site insecticides. Point mutations domain II region have been implicated resistance several insect species. Methods Findings In present paper, we identify L925I, a new...
Insects operate complex humoral and cellular immune strategies to fend against invading microorganisms. The majority of these have been characterized in Drosophila other dipterans. Information on hemipterans, including Triatominae vectors Chagas disease remains incomplete fractionated. We identified putative immune-related homologs three disease, Triatoma pallidipennis, T. dimidiata infestans (TTTs), using comparative transcriptomics based established response gene references, conjunction...
Translation is a sensitive regulatory step during cellular stress and the apoptosis response. Under such conditions, cap-dependent translation reduced internal ribosome entry site (IRES)-dependent plays major role. However, many aspects of how mRNAs are translated under remain to be elucidated. Here we report that reaper mRNA, pro-apoptotic gene from Drosophila melanogaster , in cap-independent manner. In mutant embryos devoid eukaryotic initiation factor 4E (eIF4E), transcription induced...
In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates variety of physiological processes. Here we report quantitative proteomic analysis the postfeeding in central nervous system Rhodnius prolixus, vector Chagas disease. The concentration neuropeptides NVP-like, ITG-like, kinin-precursor peptide, and neuropeptide-like precursor 1 (NPLP1) significantly changes to intake. We also performed neuropeptidomic other feeding-related organs,...
Stinkbugs (Hemiptera: Pentatomidae) are of major economic importance as pest crops. Among the species composing stinkbug complex, Nezara viridula is one most abundant in Brazil, Argentina and Southern USA. However, this has been poorly characterized at genetic physiological level. Here we sequenced analyzed complete transcriptome N. male female adults. We identified neuropeptide precursor genes G-protein coupled receptors for neuropeptides transcriptome. Mature were brain extracts by liquid...
The corn leafhopper Dalbulus maidis is the main vector of important stunting pathogens that affect maize production. Currently, there are no effective methods available to manage this pest without adverse impact on environment. In context, genomic-based technologies such as RNA interference (RNAi) provide a more environmentally friendly control strategy. Therefore, we aimed assess application RNAi in D. and determine function candidate gene related insect reproduction propagation.We have...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Chagas disease is a parasitic infection caused by Trypanosoma cruzi. It an important public health problem affecting around seven to eight million people in the Americas. A large number of hematophagous triatomine insect species, occupying diverse natural and human-modified ecological niches transmit this disease. Triatomines are long-living hemipterans that have evolved explode different habitats associate with their vertebrate hosts. Understanding molecular basis extreme physiological...