A5080434552- Olfactory and Sensory Function Studies
- Genomics and Phylogenetic Studies
- Biomedical Text Mining and Ontologies
- Advanced Chemical Sensor Technologies
- Genetic and phenotypic traits in livestock
- Insect Resistance and Genetics
- Molecular Biology Techniques and Applications
- Insect symbiosis and bacterial influences
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Biochemical Analysis and Sensing Techniques
- Insect and Arachnid Ecology and Behavior
- Insect-Plant Interactions and Control
- Fish Ecology and Management Studies
- Insects and Parasite Interactions
- CRISPR and Genetic Engineering
- Environmental DNA in Biodiversity Studies
- Gene expression and cancer classification
- Animal Genetics and Reproduction
- Insect Utilization and Effects
- Hemiptera Insect Studies
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Nutrition, Genetics, and Disease
- Genetic diversity and population structure
European Bioinformatics Institute
2018-2023
Harvard University
2013-2020
Weizmann Institute of Science
2020
University of Cambridge
2017
University of Otago
2013
Australian National University
2011
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene in our current database of which 19 for protein-coding Vertebrate (VGNC) was established 2016 assign standardized nomenclature line with vertebrate species that lack their own committees. VGNC initially assigned 15000 genes chimpanzee. We have extended this process other species, naming 14000 cow dog 13...
Abstract The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 42,000 approved gene in our current database of which 19 000 for protein-coding While we still update placeholder problematic symbols, working towards stabilizing where possible; 2000 disease associated genes now marked as stable symbol reports. All data is available the HGNC website https://www.genenames.org....
Abstract The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and names to human genes. HGNC database (www.genenames.org) currently contains over 43 000 approved gene symbols, 19 200 of which are assigned protein-coding genes, 14 pseudogenes nearly 9000 non-coding RNA public website, www.genenames.org, displays all nomenclature within Symbol Reports that contain data curated by advisors links related genomic, clinical, proteomic information. Here, we describe updates our...
Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently insects. Myriapoda is only arthropod not represented by sequenced genome. We present an analysis genome centipede Strigamia maritima. It retains compact that has undergone less gene loss shuffling than previously arthropods, many orthologues genes conserved from bilaterian ancestor have been...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Abstract Background Olfactory receptors (ORs) are G protein-coupled with a crucial role in odor detection. A typical mammalian genome harbors ~ 1000 OR genes and pseudogenes; however, different gene duplication/deletion events have occurred each species, resulting complex orthology relationships. While the human nomenclature is widely accepted based on phylogenetic classification into 18 families further subfamilies, for other mammals multiple systems currently use, thus concealing important...
Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology-evolutionary relatedness-is many cases readily determined based on sequence similarity analysis. By contrast, whether or not two directly descended from common ancestor by speciation event (orthologs) duplication (paralogs) more challenging, yet provides critical information history gene. Since 2009, this task has been focus Quest for Orthologs (QFO) Consortium. The sixth...
Multiple resources currently exist that predict orthologous relationships between genes. These differ both in the methodologies used and species they make predictions for. The HGNC Comparison of Orthology Predictions (HCOP) search tool integrates displays data from multiple ortholog prediction for a specified human gene or set An indication reliability is provided by number support it. HCOP was originally designed to show orthology mouse but has been expanded include current total 20...
New cellular functions and developmental processes can evolve by modifying existing genes or creating novel genes. Novel arise not only via duplication mutation but also acquiring foreign DNA, called horizontal gene transfer (HGT). Here we show that HGT likely contributed to the creation of a indispensable for reproduction in some insects. Long considered with unknown origin, oskar has evolved fulfil crucial role insect germ cell formation. Our analysis over 100 Oskar sequences suggests...
Primordial germ cell (PGC) formation in holometabolous insects like Drosophila melanogaster relies on maternally synthesised determinants that are asymmetrically localised to the oocyte posterior cortex. Embryonic nuclei inherit this "germ plasm" acquire PGC fate. In contrast, historical studies of basally branching (Hemimetabola) suggest a maternal requirement for line genes specification may be derived character confined principally Holometabola. However, there have been remarkably few...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Abstract The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved healing whereas elevated exhibit impaired healing. In both and humans increases age amelioration of FLII activity represents a possible therapeutic strategy for in humans. Despite analysis function variety organisms we know little the molecular mechanisms underlying action. Two new murine alleles have been produced drive constitutive or...
Abstract The vertebrate limb is one of the most intensively studied organs in field developmental biology. Limb development tetrapod vertebrates highly conserved and dependent on interaction several important molecular pathways. bone morphogenetic protein ( BMP ) signaling cascade these pathways has been shown to be crucial for aspects development. Here, we have used a X enopus laevis transgenic line, which expression inhibitor N oggin under control heat‐shock promoter hsp70 examine effects...
The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 as a sister project to the HUGO Committee, approve gene nomenclature vertebrate species without an existing dedicated committee. VGNC aims harmonize across selected line with human nomenclature, orthologs assigned same where possible. This article presents overview of and discussion key findings resulting from this work date. VGNC-approved is accessible at https://vertebrate.genenames.org additionally displayed by...
Abstract New cellular functions and developmental processes can evolve by modifying existing genes or creating novel genes. Novel arise not only via duplication mutation but also acquiring foreign DNA, called horizontal gene transfer (HGT). Here we show that HGT likely contributed to the creation of a indispensable for reproduction in some insects. Long considered with unknown origin, oskar has evolved fulfil crucial role insect germ cell formation. Our analysis over 100 Oskar sequences...
Abstract Background Olfactory receptors (ORs) are G protein-coupled with a crucial role in odor detection. A typical mammalian genome harbors ~1000 OR genes and pseudogenes; however, different gene duplication/deletion events have occurred each species, resulting complex orthology relationships. While the human nomenclature is widely accepted based on phylogenetic classification into 18 families further subfamilies, for other mammals multiple systems currently use, thus concealing important...
Abstract One of the most powerful ways to develop hypotheses regarding biological functions conserved genes in a given species, such as humans, is first look at what known about function another species. Model organism databases (MODs) and other resources are rich with functional information but difficult mine. Gene2Function (G2F) addresses broad need by integrating single online resource.
Standardized gene nomenclature supports unambiguous communication and identification of the scientific literature associated with genes. To support increasing number annotated genomes that are now available for comparative studies, authorities coordinate assignment approved names can be readily propagated across species. Theofanopoulou et al. (Theofanopoulou 2021) propose a new genes encoding oxytocin arginine vasopressin their receptors. Rather than changing to different system, we minor...
Standardized gene nomenclature supports unambiguous communication and identification of the scientific literature associated with genes. To support increasing number annotated genomes that are now available for comparative studies, authorities coordinate assignment approved names can be readily propagated across species without losing their sense meaning. Theofanopoulou et al (Theofanopoulou al. 2021) propose changes to genes encoding oxytocin arginine vasopressin receptors which would...