Mikkel Christensen
A5003292759- Trypanosoma species research and implications
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Diabetes and associated disorders
- Insect symbiosis and bacterial influences
- Aquaculture disease management and microbiota
- Genomic variations and chromosomal abnormalities
- Aquaculture Nutrition and Growth
- Pharmaceutical Practices and Patient Outcomes
- Genetics, Bioinformatics, and Biomedical Research
- Pancreatic function and diabetes
- Microbial Community Ecology and Physiology
- Blood Pressure and Hypertension Studies
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Biomedical Text Mining and Ontologies
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Genetic Mapping and Diversity in Plants and Animals
- Immunodeficiency and Autoimmune Disorders
- Bioinformatics and Genomic Networks
- Invertebrate Immune Response Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Immune Cell Function and Interaction
- Advanced Optical Sensing Technologies
Frederiksberg Hospital
2022
Copenhagen University Hospital
2022
University of Copenhagen
2022
Gentofte Hospital
2022
European Bioinformatics Institute
2013-2021
Wellcome Trust
2008-2017
University of Cambridge
2008-2015
Juvenile Diabetes Research Foundation
2010-2015
Lawrence Livermore National Laboratory
1994-2015
Cold Spring Harbor Laboratory
2013
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of explore new avenues vector control, we sequenced genomes 16 anopheline from diverse locations spanning ~100 million years evolution. Comparative analyses show faster rates gene gain loss, elevated shuffling on X chromosome, more intron losses, relative to Drosophila. Some determinants capacity,...
Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources vertebrate genomics developed in context of project (http://www.ensembl.org). Together, two provide a consistent set programmatic and interactive interfaces to rich range including reference sequence, gene models, transcriptional data, genetic variation comparative analysis. This paper provides update previous publications about resource,...
Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources vertebrate genomics developed in project (http://www.ensembl.org). Together, two provide a consistent set of programmatic and interactive interfaces to rich range including genome sequence, gene models, transcript genetic variation, comparative analysis. This paper provides update previous publications about resource, with focus on recent...
Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources vertebrate genomics developed in context of project (http://www.ensembl.org). Together, two provide a consistent set interfaces to genomic across tree life, including reference genome sequence, gene models, transcriptional data, genetic variation and comparative analysis. Data may be accessed via our website, online tools platform...
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with EuPathDB projects. As a Bioinformatics Center funded by National Institutes Health, additional support from Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists fungi) relevant free-living or non-pathogenic species hosts. Designed to empower researchers access Omics data...
Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is major vector Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced genome R. prolixus, generated assembled sequences covering 95% (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed,...
Abstract Ensembl Genomes (https://www.ensemblgenomes.org) provides access to non-vertebrate genomes and analysis complementing vertebrate resources developed by the project (https://www.ensembl.org). The two collectively present genome annotation through a consistent set of interfaces spanning tree life presenting sequence, annotation, variation, transcriptomic data comparative analysis. Here, we our largest increase in plant, metazoan fungal since project's inception creating one world's...
Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species. The project exploits and extends technologies genome annotation, analysis dissemination, developed in the context of vertebrate-focused project, provides a complementary set resources species through consistent programmatic interactive interfaces. These provide access to including reference sequence, gene models, transcriptional data, polymorphisms comparative...
Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. distinguished from other Diptera by unique adaptations, including lactation birthing live young (obligate viviparity), a vertebrate blood-specific diet both sexes, obligate bacterial symbiosis. This work describes comparative analysis six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, austeni), Palpalis palpalis, fuscipes), Fusca...
T1DBase ( http://www.t1dbase.org ) is web platform, which supports the type 1 diabetes (T1D) community. It integrates genetic, genomic and expression data relevant to T1D research across mouse, rat human presents this user as a set of pages tools. This update describes incorporation new sets, tools curation efforts well website design simplify site use. New sets include curated summary from four genome-wide association studies T1D, HaemAtlas—a tool query gene levels in haematopoietic cells...
We compiled sequences of previously published aberrant 3′ splice sites (3′ss) that were generated by mutations in human disease genes. Cryptic 3′ss, defined here as those resulting from a mutation the 3′YAG consensus, more frequent exons than introns. They clustered ∼20 nt region adjacent to authentic suggesting their under-representation introns is due depletion AG dinucleotides polypyrimidine tract (PPT). In contrast, most 3′ss induced outside consensus (designated ' de novo ') The...
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for protection from type 1 diabetes (T1D) provided by insulin-dependent susceptibility region 10 (Idd10), a <1 Mb on mouse chromosome 3. In this study, we provide further support hypothesis Cd101 is Idd10 using haplotype expression analyses novel congenic strains coupled to development knockout mouse. Susceptibility T1D was correlated with genotype-dependent multiple cell subsets,...
Abstract The precise localization of gene expression within the developing embryo, and how it changes over time, is one most important sources information for elucidating function. As a searchable resource, this has up until now been largely inaccessible to Xenopus community. Here, we present new database patterns, queryable by specific location or region in embryo. Pattern matching can be driven either from an existing situ image, user‐defined pattern based on development stage schematic...
Nonobese diabetic (NOD) mice congenic for C57BL/10 (B10)-derived genes in the Idd9 region of chromosome 4 are highly protected from type 1 diabetes (T1D). has been divided into three protective subregions (Idd9.1, 9.2, and 9.3), each which partially prevents disease. In this study we have fine-mapped Idd9.1 Idd9.2 regions, revealing further genetic complexity with at least two additional contributing to protection T1D. Using NOD sequence bacterial artificial clones regions as well...
By congenic strain mapping using autoimmune NOD.C57BL/6J mice, we demonstrated previously that the type 1 diabetes (T1D) protection associated with insulin-dependent (Idd)10 locus on chromosome 3, originally identified by linkage analysis, was in fact due to three closely linked Idd loci: Idd10, Idd18.1, and Idd18.3. In this study, define two additional loci--Idd18.2 Idd18.4--within boundaries of cluster disease-associated genes. Idd18.2 is 1.31 Mb contains 18 genes, including Ptpn22, which...
Orchestration of every National Ignition Facility (NIF) shot cycle is managed by the Integrated Computer Control System (ICCS), which uses a scalable software architecture running code on more than 1950 front-end processors, embedded controllers, and supervisory servers. The ICCS operates laser industrial control hardware containing 66 000 monitor points to ensure that all NIF's beams arrive at target within 30 ps each other are aligned pointing accuracy less 50 μm root-mean-square, while...
Musalais is a traditional alcoholic beverage made by the Uighur people in southern Xinjiang, China. Theinitial fermentation juice obtained prolonged boiling of local grape and residues. In thecurrent study, 242 yeast isolates were from 18 samples (grapes, derived starting products, andprogressive stages fermentation), 20 phenotypes distinguished, based on colony characteristicson WL nutrient agar. Fifty representative selected found to belong eight genera (basedon rRNA gene sequence...
Non-sequence gene data (images, literature, etc.) can be found in many different public databases. Access to these is mostly by text based methods using names; however, annotation neither complete, nor fully systematic between organisms, and also not generally stable over time. This provides some challenges for access, especially cross-species searches. We propose a method non-sequence retrieval on sequence similarity, which removes dependence work was motivated the need provide better...
Background: Tsetse flies (Glossina sp.) are the sole vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. distinguished from other Diptera by unique adaptations, including lactation birthing live young (obligate viviparity), a vertebrate blood specific diet both sexes obligate bacterial symbiosis. This work describes comparative analysis six Glossina genomes representing three sub-genera: Morsitans (G. morsitans (G.m. morsitans), G. pallidipes, austeni), Palpalis...