A5046812053- Insect Resistance and Genetics
- Insect and Pesticide Research
- Entomopathogenic Microorganisms in Pest Control
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Insect-Plant Interactions and Control
- Insect symbiosis and bacterial influences
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Insect behavior and control techniques
- Insect Pheromone Research and Control
- Entomological Studies and Ecology
- Lepidoptera: Biology and Taxonomy
- Diptera species taxonomy and behavior
- Insect Utilization and Effects
- Malaria Research and Control
- Insects and Parasite Interactions
- Vector-Borne Animal Diseases
- Plant and animal studies
- Mosquito-borne diseases and control
- Plant and Biological Electrophysiology Studies
- Pancreatitis Pathology and Treatment
- Fungal Biology and Applications
- Lipid metabolism and biosynthesis
- Hemiptera Insect Studies
Universidad Independiente
2024
Biochemistry Research Institute of La Plata
1993-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2020
Universidad Nacional de La Plata
2009-2020
Centro Científico Tecnológico - San Juan
2020
Copenhagen Business School
2020
Centro Científico Tecnológico - La Plata
2016-2019
Instituto de Biotecnología y Biología Molecular
2001-2014
Instituto de Biomedicina de Valencia
2008
Universidad Nacional Autónoma de México
2000-2008
Significance Malaria incidence has halved since 2000, with 80% of the reduction attributable to use insecticides, which now are under threat resistance. Understanding mechanisms insecticide resistance is a key step in delaying and tackling phenomenon. This study provides evidence cuticular mechanism that slows uptake pyrethroids, contributing phenotype potentially broadening multiple classes, thus providing additional challenges management. Quantitative modification hydrocarbons associated...
Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is major vector Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced genome R. prolixus, generated assembled sequences covering 95% (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed,...
The Na(+):K(+):2Cl(-) cotransporter (NKCC2) is the target of loop diuretics and mutated in Bartter's syndrome, a heterogeneous autosomal recessive disease that impairs salt reabsorption kidney's thick ascending limb (TAL). Despite importance this cation/chloride (CCC), mechanisms underlie its regulation are largely unknown. Here, we show intracellular chloride depletion Xenopus laevis oocytes, achieved by either coexpression K-Cl KCC2 or low-chloride hypotonic stress, activates NKCC2...
PII-disintegrins, cysteine-rich polypeptides broadly distributed in the venoms of geographically diverse species vipers and rattlesnakes, antagonize adhesive functions β1 β3 integrin receptors. PII-disintegrins evolved Viperidae by neofunctionalization disintegrin-like domains duplicated PIII-snake venom hemorrhagic metalloproteinase (SVMP) genes recruited into proteome before radiation advanced snakes. Minimization gene (loss introns coding regions) protein structures (successive loss...
Triatoma infestans-mediated transmission of Tripanosoma cruzi, the causative agent Chagas disease, remains as a major health issue in southern South America. Key factors T. infestans prevalence specific areas geographic Gran Chaco region-which extends through northern Argentina, Bolivia, and Paraguay-are both recurrent reinfestations after insecticide spraying emerging pyrethroid-resistance over past ten years. Among alternative control tools, pathogenicity entomopathogenic fungi against...
Significance Although entomopathogenic fungi and their invertebrate hosts share a >300 million year co-evolutionary history, little is known concerning the biochemical genetic basis of insect defensive tactics countermeasures evolved evolving by pathogen to thwart these defenses. Our results provide molecular mechanism help explain why some insects are more resistant broad host-range fungi. We identify beetle cuticular secretions fungal detoxifying enzyme as components an arms race...
Malaria incidence has halved since the year 2000, with 80% of reduction attributable to use insecticides. However, insecticide resistance is now widespread, rapidly increasing in spectrum and intensity across Africa, may be contributing increase malaria 2018. The role detoxification enzymes target site mutations been documented major vector Anopheles gambiae ; however, emergence striking resistant phenotypes suggests occurrence additional mechanisms. By comparing legs, most relevant insect...
The insect epicuticle or waxy layer comprises a heterogeneous mixture of lipids that include abundant levels long-chain alkanes, alkenes, wax esters and fatty acids. This structure represents the first barrier against microbial attack for broad-host-range pathogens, such as Beauveria bassiana, it is initial interface mediating host-pathogen interaction, since these organisms do not require any specialized mode entry infect target hosts via cuticle. B. bassiana able to grow on straight chain...
Background Current Chagas disease vector control strategies, based on chemical insecticide spraying, are growingly threatened by the emergence of pyrethroid-resistant Triatoma infestans populations in Gran Chaco region South America. Methodology and findings We have already shown that entomopathogenic fungus Beauveria bassiana has ability to breach insect cuticle is effective both against pyrethroid-susceptible T. infestans, laboratory as well field assays. It also known lipids play a major...
Abstract Fatty acid synthase is a multifunctional enzyme involved in the formation of fatty acids. Despite role acids cell signalling and energy metabolism, as precursors to pheromones hydrocarbons that waterproof cuticle, insect synthases have been scarcely studied. Here we perform molecular characterization three genes ( RPRC000123 , RPRC000269 RPRC002909 ) Chagas disease vector, Rhodnius prolixus . Gene expression screening by reverse transcription quantitative PCR showed are expressed...
Insect resistance to chemical insecticides is attributed a combination of different mechanisms, such as metabolic resistance, knockdown and the cuticular or penetration factor. The insect integument offers an efficient barrier against contact its role factor has been previously reported; however, there no information about potential function in resistance. Cytochrome P450 genes (CYP) are highly expressed fat body several insects thus play key their Here, we describe new members that belong...
Transforming growth factor-beta (TGF-beta) is a key mediator in the pathogenesis of renal diseases. Betaglycan, also known as type III TGF-beta receptor, regulates action by modulating its access to I and II receptors. Betaglycan potentiates TGF-beta; however, soluble betaglycan, which produced shedding membrane-bound potent antagonist TGF-beta. In present work, we have used recombinant form betaglycan (SBG) prevent damage genetically obese diabetic db/db mice. Eight-wk-old or nondiabetic...
Abstract Background The triatomine bugs are vectors of the protozoan parasite Trypanosoma cruzi , causative agent Chagas disease. Aggregation behavior plays an important role in their survival by facilitating location refuges and cohesion aggregates, helping to keep them safely assembled into shelters during daylight time, when they vulnerable predators. There evidences that aggregation is mediated thigmotaxis, volatile cues from faeces, hexane-extractable contact chemoreceptive signals...