A5009775338- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Genetic diversity and population structure
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Viral Infections and Vectors
- Identification and Quantification in Food
- Chromosomal and Genetic Variations
- Hemoglobinopathies and Related Disorders
- Insect symbiosis and bacterial influences
- Evolution and Genetic Dynamics
- Parasitic Diseases Research and Treatment
- Dengue and Mosquito Control Research
- Zoonotic diseases and public health
- Insect Utilization and Effects
- Plant and animal studies
- Parasite Biology and Host Interactions
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Viral-associated cancers and disorders
- Animal Behavior and Reproduction
- Primate Behavior and Ecology
- Physiological and biochemical adaptations
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2013-2024
Institut de Recherche pour le Développement
2014-2024
Centre National de la Recherche Scientifique
2013-2024
Université de Montpellier
2013-2024
Institut Pasteur de Dakar
2022-2024
Institut de Recherche pour le Développement
2024
Centre National de Recherche et de Formation sur le Paludisme
2000-2023
Agropolis International
2009-2023
Institut de Recherche en Sciences de la Santé
2007-2020
Centre Muraz
2009-2020
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of explore new avenues vector control, we sequenced genomes 16 anopheline from diverse locations spanning ~100 million years evolution. Comparative analyses show faster rates gene gain loss, elevated shuffling on X chromosome, more intron losses, relative to Drosophila. Some determinants capacity,...
Speciation among members of the Anopheles gambiae complex is thought to be promoted by disruptive selection and ecological divergence acting on sets adaptation genes protected from recombination polymorphic paracentric chromosomal inversions. However, shared polymorphisms between M S molecular forms An. insufficient information about their relationship with challenge this view. We used Geographic Information Systems, Ecological Niche Factor Analysis, Bayesian multilocus genetic clustering...
Restrictions to gene flow among molecular forms of the mosquito Anopheles gambiae sensu stricto reveal an ongoing speciation process affecting epidemiology malaria in sub-Saharan Africa.
Ongoing lineage splitting within the African malaria mosquito Anopheles gambiae is compatible with ecological speciation, evolution of reproductive isolation by divergent natural selection acting on two populations exploiting alternative resources. Divergence between molecular forms (M and S) identified fixed differences in rDNA, characterized marked, although incomplete, occurring West Central Africa. To elucidate role that ecology geography play we carried out a countrywide analysis An. M...
Abstract. To obtain information on adult populations of Afrotropical malaria vector mosquitoes, mark‐release‐recapture experiments were performed with Anopheles females collected from indoor resting‐sites in a savanna area near Ouagadougou, Burkina Faso, during September 1991 and 1992. Results used to estimate the absolute population densities, daily survival rates, dispersal parameters vectors that area. In total 7260 female marked released, which 106 recaptured release village 6...
Abstract Feeding behaviour of the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) was monitored for 12 months (March 2003−February 2004) in Konso District southern Ethiopia (5°15′N, 37°28′E). More than 45 000 An. females were collected by host‐baited sampling methods (light‐traps, human landing catches, cattle‐baited traps) and from resting sites (huts pit shelters). In village Fuchucha, where ratio cattle : humans 0.6 1, 51% outdoor‐resting mosquitoes 66% those indoors had...
Abstract The association between fitness-related phenotypic traits and an environmental gradient offers one of the best opportunities to study interplay natural selection migration. In cases in which specific genetic variants also show such clinal patterns, it may be possible uncover mutations responsible for local adaptation. malaria vector, Anopheles gambiae, is associated with a latitudinal cline aridity Cameroon; large inversion on chromosome 2L this mosquito shows differences frequency...
Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations species exhibit varying levels reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited greatest genetic divergence, but divergence was also observed elsewhere...
Urban malaria is becoming a major health priority across Africa. A study was undertaken to assess the importance of urban pollution and agriculture practice on distribution susceptibility insecticide vectors in two main cities Cameroon.Anopheline larval breeding sites were surveyed water samples analysed monthly from October 2009 December 2010. Parameters included turbidity, pH, temperature, conductivity, sulfates, phosphates, nitrates, nitrites, ammonia, aluminium, alkalinity, iron,...
Background Anthropogenic habitat disturbance is a prime cause in the current trend of Earth's reduction biodiversity. Here we show that human footprint on Central African rainforest, which resulting deforestation and growth densely populated urban agglomerates, associated to ecological divergence cryptic speciation leading adaptive radiation within major malaria mosquito Anopheles gambiae. Methodology/Principal Findings In southern Cameroon, frequency two molecular forms–M S–among...
To test for the effects of host accessibility on blood-feeding behavior, we assessed degrees anthropophily malaria mosquito Anopheles gambiae at two stages behavioral sequence foraging, in a rice growing area near Bobo-Dioulasso, Burkina Faso, where humans are not readily accessible because years generalized use (mostly non-impregnated) bed nets. First, patterns selection were by identification blood meal origin indoor-resting samples. Inherent preferences then determined odor-baited entry...
Abstract Previous efforts to uncover the genetic underpinnings of ongoing ecological speciation M and S forms African malaria vector Anopheles gambiae revealed two centromere‐proximal islands divergence on X chromosome 2. Under assumption considerable gene flow between S, these persistently divergent genomic were widely considered be ‘speciation islands’. In course microarray‐based mapping, we discovered a third centromere‐associated island 3, which was validated by targeted re‐sequencing....
Abstract Background Limitations in the ability of organisms to tolerate environmental stressors affect their fundamental ecological niche and constrain distribution specific habitats. Evolution tolerance, therefore, can engender dynamics. Forest populations afro-tropical malaria mosquito Anopheles gambiae have been shown adapt historically unsuitable larval habitats polluted with decaying organic matter that are found densely populated urban agglomerates Cameroon. This process has resulted...
Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched vector populations, and countries with high face daunting challenge sustain limited set surveillance intervention tools. Here we report on the second phase project build an open resource high-quality data genome variation among natural populations major African species Anopheles gambiae coluzzii . We analyzed whole genomes 1142 individual...
In the city of Yaoundé in Cameroon malaria is predominately transmitted by M and S molecular forms Anopheles gambiae both are resistant to pyrethroid insecticides DDT. Mutations target site these insecticides, present at a high frequency vectors this city, contribute resistance profile. To identify additional mechanisms, expression profile multiple DDT-resistant field populations was compared laboratory-susceptible populations.The prevalence DDT highest form population originating from...
Abstract Complexes of closely related species provide key insights into the rapid and independent evolution adaptive traits. Here, we described studied Anopheles fontenillei sp.n., a new in gambiae complex that recently discovered forested areas Gabon, Central Africa. Our analysis placed taxon phylogenetic tree An . complex, revealing important introgression events with other members complex. Particularly, detected recent introgression, coluzzii , genes directly involved vectorial capacity....
Significance Transmission of malarial parasites occurs via the bites Anopheles mosquitoes, whose blood-feeding behavior modulates risk infection. In many malaria endemic regions, eradication strategies rely on reducing transmission by targeting nocturnal with insecticidal nets. However, a proportion mosquitoes may naturally feed when humans are not protected nets, setting ceiling to efficacy massive net-based interventions. Bangui, Central African Republic, 20 30% daily exposure indoor...
Abstract. Mosquito responses to carbon dioxide were investigated in Noungou village, 30 km northeast of Ouagadougou the Sudan savanna belt Burkina Faso, West Africa. Species primary interest main malaria vectors Anopheles gambiae S.S. and An.arabiensis, sibling species belonging An.gambiae complex. Data forAn.finestus, An.pharoensis, Culex quinquefasciatus Mansonia uniformis also analysed. Carbon was used at concentrations 0.04‐0.6% (cf. 0.03% ambient concentration) for attracting mosquitoes...
The role of odors in mosquito host preferences was studied a village near Ouagadougou, Burkina Faso. Two odor-baited entry-traps were put beside one another and choice odor-laden air blown out them. Odors human calf (of similar mass) drawn from two tents which each separately concealed. Allowances made for trap position, differences human-subject attractiveness, CO2 levels, contamination with alternative odors. Choices the human-baited greater than 0.5 random expectation by Anopheles gambiae...
Suitability of environmental conditions determines a species distribution in space and time. Understanding modelling the ecological niche mosquito disease vectors can, therefore, be powerful predictor risk exposure to pathogens they transmit. In Africa, five anophelines are responsible for over 95% total malaria transmission. However, detailed knowledge geographic requirements these is date still inadequate. Indoor-resting mosquitoes were sampled from 386 villages covering full range...
The African malaria mosquito Anopheles gambiae is diversifying into ecotypes known as M and S forms. This process thought to be promoted by adaptation different larval habitats, but its genetic underpinnings remain elusive. To identify candidate targets of divergent natural selection in S, we performed genomewide scanning paired population samples from Mali, followed resequencing genotyping five locations West, Central, East Africa. Genome scans revealed a significant peak M-S divergence on...
Chromosomal inversions are thought to confer a selective advantage in alternative habitats by protecting co-adapted alleles from recombination. The frequencies of two (2La and 2Rb) the afro-tropical malaria mosquito Anopheles gambiae change gradually along geographical clines, increasing frequency with degree aridity. Such clines can result gene flow local selection acting upon karyotypes cline, suggesting that these may be associated tolerance xeric conditions. Since water loss represents...
Understanding how divergent selection generates adaptive phenotypic and population diversification provides a mechanistic explanation of speciation in recently separated species pairs. Towards this goal, we sought ecological gradients divergence between the cryptic malaria vectors Anopheles coluzzii An. gambiae then looked for physiological trait that may underlie such divergence. Using large set occurrence records eco-geographic information, built distribution model to predict predominance...