Victoria J. Simpson
A5088650493- Malaria Research and Control
- Mosquito-borne diseases and control
- Atmospheric chemistry and aerosols
- Atmospheric and Environmental Gas Dynamics
- Photochemistry and Electron Transfer Studies
- Atmospheric Ozone and Climate
- Biochemical Analysis and Sensing Techniques
- Insect Resistance and Genetics
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- HIV Research and Treatment
- Free Radicals and Antioxidants
- Advanced Chemical Sensor Technologies
- vaccines and immunoinformatics approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Mitochondrial Function and Pathology
- Viral Infections and Outbreaks Research
- Carbon Dioxide Capture Technologies
- Adipose Tissue and Metabolism
- Analytical Chemistry and Chromatography
- Radical Photochemical Reactions
- Anesthesia and Sedative Agents
- Climate Change Policy and Economics
- Spectroscopy and Laser Applications
Wellcome Sanger Institute
2019-2025
Myanmar Oxford Clinical Research Unit
2023
University of Oxford
2019-2021
Genomics (United Kingdom)
2019-2021
Walter Reed Army Institute of Research
2019
Centre for Human Genetics
2019
Health Data Research UK
2019
University of Leeds
2014
Children's Hospital Colorado
1996-2004
University of Colorado Denver
1996-2004
Abstract The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios direct typing candidate loci an additional 15,000 samples. We identify five replicable associations with levels evidence including newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth the...
DNA, isolated from age-synchronous senescent populations of Caenorhflbditiselegans has been quantitatively and qualitatively analyzed for the presence 5-methylcytosine. High performance liquid chromatography on two wild-type several mutant strains C.elegans failed to detect any The restriction endonuclease isoschizomers. HpaII MapI , were used digest genomic DNA after CaCl purification 5′ cytosine methylation at age. We conclude that does not contain detectable (0.01 mole percent) levels
Ebb and flow of parasite populations The population genetics the malaria Plasmodium falciparum across Africa is poorly understood but important to know for grasping risks dynamics spread drug resistance. Harnessing power genomics, Amambua-Ngwa et al. Diversity Network found substantial structure within that consistent with human vector divergence (see Perspective by Sibley). Specific signatures selection antimalarial drugs were detected, along indications effect colonization slavery....
Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched vector populations, and countries with high face daunting challenge sustain limited set surveillance intervention tools. Here we report on the second phase project build an open resource high-quality data genome variation among natural populations major African species Anopheles gambiae coluzzii . We analyzed whole genomes 1142 individual...
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for surveillance malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale projects by integrating simple sample collection procedures routine public health procedures. Methods: Samples from symptomatic patients are processed SpotMalaria, high-throughput system produces comprehensive set genotypes comprising...
<ns3:p>This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples <ns3:italic>Plasmodium vivax</ns3:italic> collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 contributed by VivaxGEN partner studies in addition to previously published from these other sources. We provide genotype calls over 4.5 million variable positions including 3 single nucleotide polymorphisms (SNPs), as well short indels tandem...
CH 4 emissions from rice paddies have been estimated to the year 2025. A model based on current production per capita values (1989) for 94 major rice‐producing countries and United Nations population predictions was used calculate future emission fluxes of . Results show that are predicted increase by an average 1.1% yr −1 1990 level 97 Tg 145 in
Abstract Traditionally, patient travel history has been used to distinguish imported from autochthonous malaria cases, but the dormant liver stages of Plasmodium vivax confound this approach. Molecular tools offer an alternative method identify, and map cases. Using machine learning approaches incorporating hierarchical fixation index decision tree analyses applied 799 P. genomes 21 countries, we identified 33-SNP, 50-SNP 55-SNP barcodes (GEO33, GEO50 GEO55), with high capacity predict...
The emergence of insecticide resistance is threatening the efforts malaria control programmes, which rely heavily on a limited arsenal insecticidal tools, such as insecticide-treated bed nets. Importantly, genomic surveillance vectors can provide critical, policy-relevant insights into presence and evolution resistance, allowing us to maintain extend shelf life these interventions. Yet complex genetic architecture combined with resource constraints in malaria-endemic settings, have thus far...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of hydroxymethyl radicals with oxygen, nitric oxide, and nitrogen dioxide at room temperaturePalle Pagsberg, Jette Munk, Christopher Anastasi, Victoria J. SimpsonCite this: Phys. Chem. 1989, 93, 13, 5162–5165Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/j100350a028https://doi.org/10.1021/j100350a028research-articleACS PublicationsRequest...
Background Long-sleep (LS) and short-sleep (SS) mice, initially selected for differential sensitivity to ethanol, also exhibit propofol. By interbreeding LS SS mice obtain progeny whose chromosomes are a patchwork of the chromosomes, authors determined whether propofol cosegregates with any particular chromosomal region(s). Such cosegregation is essence genetic linkage mapping first step toward isolating gene that can modulate in mammals. A underlying quantitative trait such as anesthetic...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUV spectrum and the kinetics reaction pathways of self-reaction hydroxyethyl radicalsChristopher. Anastasi, Victoria. Simpson, Jette. Munk, Palle. PagsbergCite this: J. Phys. Chem. 1990, 94, 16, 6327–6331Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/j100379a033https://doi.org/10.1021/j100379a033research-articleACS PublicationsRequest reuse...
Abstract Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched vector populations, and countries with high face daunting challenge sustain limited set surveillance intervention tools. Here we report on the second phase project build an open resource quality data genome variation among natural populations major African species Anopheles gambiae coluzzii . We analysed whole genomes 1,142 individual...
ABSTRACT The population structure of the malaria parasite Plasmodium falciparum can reveal underlying demographic and adaptive evolutionary processes. Here, we analyse in 4,376 P. genomes from 21 countries across Africa. We identified a strongly differentiated cluster parasites, comprising ∼1.2% samples analysed, geographically distributed over 13 continent. Members this cluster, named AF1, carry genetic background consisting large number highly variants, rarely observed outside at multitude...
ABSTRACT Background Genetic surveillance of Plasmodium falciparum (Pf) is an important tool for tracking antimalarial resistant strains, informing decision-making by National Malaria Control Programmes (NMCPs). Here, we present analysis 5,754 samples collected the GenRe-Mekong project, in collaboration with NMCPs Greater Mekong Subregion (GMS), powered new user-friendly visualization tools developed to translate genomic data into accessible actionable information. Methods Samples from...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrum and mutual kinetics of .beta.-hydroxyethylperoxo radicalsC. Anastasi, D. J. Muir, V. Simpson, P. PagsbergCite this: Phys. Chem. 1991, 95, 15, 5791–5797Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/j100168a016https://doi.org/10.1021/j100168a016research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations18LEARN...
The future global emission of CH 4 from enteric fermentation in animals has been estimated for cattle, sheep, and buffalo, which together contribute approximately 91% the total emitted domesticated at present. A simple model used to relate livestock levels national human populations each country involved breeding three species included this analysis. United Nations population predictions 2025 were then estimate emissions. variational analysis was carried out investigate effect changes both...
Abstract Imported cases present a considerable challenge to the elimination of malaria. Traditionally, patient travel history has been used identify imported cases, but long-latency liver stages confound this approach in Plasmodium vivax . Molecular tools and map offer more robust approach, that can be combined with drug resistance other surveillance markers high-throughput, population-based genotyping frameworks. Using machine learning incorporating hierarchical FST (HFST) decision tree...