Michael D. Wilson
A5083608561- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Malaria Research and Control
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Avian ecology and behavior
- Helminth infection and control
- Insects and Parasite Interactions
- Computational Drug Discovery Methods
- Trypanosoma species research and implications
- Hydrocarbon exploration and reservoir analysis
- Insect Pest Control Strategies
- Insect symbiosis and bacterial influences
- Hemoglobinopathies and Related Disorders
- Hydraulic Fracturing and Reservoir Analysis
- Child Nutrition and Water Access
- Insect Resistance and Genetics
- Geological Studies and Exploration
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- HIV Research and Treatment
- Iron Metabolism and Disorders
- Complement system in diseases
University of Ghana
2016-2025
Noguchi Memorial Institute for Medical Research
2016-2025
Dorset County Hospital
2025
Hospital for Sick Children
2024
Loyola University Medical Center
2019-2023
Loyola University Chicago
2020-2023
Loughborough University
2023
University Hospitals Dorset NHS Foundation Trust
2023
University of Illinois Urbana-Champaign
2022
Pan African Institute for Development
2022
Background. Several African countries have adopted a biannual ivermectin distribution strategy in some foci to control and eliminate onchocerciasis. In 2010, the Ghana Health Service started combat transmission hotspots suboptimal responses treatment. We assessed epidemiological impact of first 3 years this quantified over 2 consecutive rounds treatment 10 sentinel communities. Methods. evaluated Onchocerca volvulus community microfilarial intensity prevalence persons aged ≥20 before first,...
Abstract The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios direct typing candidate loci an additional 15,000 samples. We identify five replicable associations with levels evidence including newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth the...
To investigate the impact of urban agriculture on malaria transmission risk in Accra larval and adult stage mosquito surveys, were performed. Local was implicated as Anopheles spp. found breeding infected Anophele s mosquitoes resting houses study sites. The predominant species gambiae s.s.. relative proportion molecular forms within a subset specimens 86% S-form 14% M-form. Culex quinquefasciatus outdoor biting rates respectively three four times higher areas around agricultural sites (UA)...
A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence 45%, peaking those 11–20 years old (58.5%). In children, risk factors for included coinfection with malaria and increased serum immunoglobulin G reactivity to secretory antigens. Risk adults poor nutritional status, not using a latrine, wearing shoes, occupation (farming). Although albendazole therapy associated an egg reduction rate 82%,...
Anopheles vectors of malaria are supposedly less common in urban areas as a result pollution, but there is increasing evidence their adaptation to organically polluted water bodies. This study characterized the breeding habitats mosquitoes two major southern Ghana; Accra (AMA) and Sekondi-Takoradi (STMA) Metropolitan Areas, during dry wet seasons.Anopheles mosquito larvae were sampled using standard dipping methods determine larval densities. The origin, nature stability 21 randomly selected...
Abstract Sero-surveillance can monitor and project disease burden risk. However, SARS-CoV-2 antibody test results produce false positive results, limiting their efficacy as a sero-surveillance tool. False are associated with malaria exposure, understanding this association is essential to interpret from malaria-endemic countries. Here, pre-pandemic samples eight endemic non-endemic countries four continents were tested by ELISA measure Spike S1 subunit reactivity. Individuals acute infection...
The African malaria mosquito Anopheles gambiae is diversifying into ecotypes known as M and S forms. This process thought to be promoted by adaptation different larval habitats, but its genetic underpinnings remain elusive. To identify candidate targets of divergent natural selection in S, we performed genomewide scanning paired population samples from Mali, followed resequencing genotyping five locations West, Central, East Africa. Genome scans revealed a significant peak M-S divergence on...
Anopheles gambiae s.s mosquitoes are important vectors of lymphatic filariasis (LF) and malaria in Ghana. To better understand their ecological aspects influence on disease transmission, we examined the spatial distribution An. (M S) molecular forms associated environmental factors, determined relationship with prevalence. Published current data available species Ghana were collected a database for analysis, study sites georeferenced mapped. Using sites, derived from climate, vegetation...
In 2005, Ghana adopted artemisinin-based combination therapy (ACT) for primary treatment of falciparum malaria. A comprehensive study the drug-resistance-associated mutations and their genetic lineages will lead to a better understanding evolution antimalarial drug resistance in this region.The pfcrt, pfmdr1, dhps, dhfr associated with chloroquine (CQ) sulfadoxine-pyrimethamine (SP) microsatellite loci flanking these genes were genotyped Plasmodium isolates from Ghana.The prevalence both CQ...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of protective effect has proved difficult define as G6PD multiple allelic variants with different effects in males and females, it heterogeneous on clinical outcome P. infection. Here we report an analysis forms a large multi-centre case-control study severe using WHO classification mutations estimate each individual’s level enzyme activity from...
Abstract Background Recent data from Ghana indicates that after seven rounds of annual mass drug administration (MDA) there is still sustained transmission albeit at low levels in certain areas where Anopheles melas , An. gambiae s.s., Mansonia and Culex species are the main biting mosquitoes. s.l. funestus known vectors a recent report indicated could transmit level microfilaraemia. However, because not found everywhere was need to determine whether any other culicine also be playing role...
Symbiotic bacteria can have important implications in the development and competence of disease vectors. In Anopheles mosquitoes, composition midgut microbiota is largely influenced by larval breeding site, but exact factors shaping this are currently unknown. Here, we examined whether proximity to urban areas seasons an impact on microbial community two major malaria vectors Africa, An. coluzzii gambiae. Larvae pupae were collected from selected habitats districts Ghana during dry rainy...
The World Health Organization (WHO) aims at eliminating onchocerciasis by 2020 in selected African countries. Current control focuses on community-directed treatment with ivermectin (CDTI). In Ghana, persistent transmission has been reported despite long-term control. We present spatial and temporal patterns of relation to history.
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome virus 2 (SARS-CoV-2) has impacted negatively on public health and socioeconomic status, globally. Although, there are currently no specific drugs approved, several existing being repurposed, but their successful outcomes not guaranteed. Therefore, search for novel therapeutics remains a priority. We screened inhibitors of SARS-CoV-2 main protease receptor-binding domain spike protein from an...
Abstract. The Ghanaian National Malaria Control Programme has prioritized insecticide‐treated materials as a key strategy for malaria control. We report on survey of the distribution molecular forms Anopheles gambiae Giles (Diptera: Culicidae) and insecticide resistance (the kdr mutation), carried out by sampling mosquitoes from 11 locations in Ghana one additional site Burkina Faso. M S An. were found to occur sympatry southern Ghana. form predominated throughout its coastal savannah,...
Abstract We investigated the prevalence of malaria and associated risk factors in children living urban Ghana. Malaria was with low hemoglobin concentration, socioeconomic status, higher age. Our findings indicate that African poor are seriously affected by irrigated agriculture may increase this risk.
Mark-release-recapture (MRR) experiments were conducted with emerging Anopheles gambiae s.l. and Anophelesfunestus Giles at Jaribuni Mtepeni in Kilifi, along the Kenyan Coast. Of 739 1246 released Mtepeni, 24.6 4.33% recaptured, respectively. The daily survival probability was 0.96 for An. funestus 0.95 0.83 0.95, respectively, Mtepeni. maximum flight distance recorded 661 m. high of estimated accounts continuous transmission malaria coast. This study also shows that release young, emergent...
Development times of eggs, larvae and pupae vectors onchocerciasis ( Simulium spp.) Onchocerca volvulus within the adult females decrease with increasing temperature. At above 25°C, parasite could reach its infective stage in less than 7 days when transmit after only two gonotrophic cycles. After incorporating exponential functions for vector development into a novel blackfly population model, it was predicted that fly numbers Liberia Ghana would peak at air temperatures 29°C 34°C, about 3°C...