A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence 45%, peaking those 11–20 years old (58.5%). In children, risk factors for included coinfection with malaria and increased serum immunoglobulin G reactivity to secretory antigens. Risk adults poor nutritional status, not using a latrine, wearing shoes, occupation (farming). Although albendazole therapy associated an egg reduction rate 82%,...

Anopheles vectors of malaria are supposedly less common in urban areas as a result pollution, but there is increasing evidence their adaptation to organically polluted water bodies. This study characterized the breeding habitats mosquitoes two major southern Ghana; Accra (AMA) and Sekondi-Takoradi (STMA) Metropolitan Areas, during dry wet seasons.Anopheles mosquito larvae were sampled using standard dipping methods determine larval densities. The origin, nature stability 21 randomly selected...

Introduction Diarrhoea accounts for high morbidity and mortality in children adults worldwide. Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL-PE) Diarrhoeagenic Escherichia coli (DEC) contribute to prolonged hospitalization because of their resistance virulence properties aiding the spread diarrhoeal disease delayed treatment. Aim To determine DEC antimicrobial ESBL-PE isolated among diarrhoea patients attending two health facilities Ghana. Methods Stool samples were...

Ghana’s lymphatic filariasis (LF) elimination was intensified by Global Programme to Eliminate Lymphatic in 2000. LF transmission interrupted some endemic district, yet, persistent others. This study investigated characteristics of Wuchereria bancrofti that potentially contribute districts after prolonged mass chemotherapy (≧15yrs) expected interrupt transmission. Participants’ finger-prick blood screened for antigenaemia and positives followed night detect microfilariae. The...

Background Red blood cell (RBC) polymorphisms are common in malaria endemic regions and known to protect against severe forms of the disease. Therefore, it is important screen for these drugs or vaccines efficacy trials. This study was undertaken evaluate associations between clinical RBC assess biological interactions that may be necessary consideration when designing Method In a cross-sectional 341 febrile children less than five years age, including sickle gene G6PD deficiency evaluated...

This study, undertaken as a component of the global Dracunculiasis Eradication Program (DEP), was designed to provide molecular tools distinguish Dracunculus medinensis, nematode causing human dracunculiasis, from other tissue-dwelling nematodes, including species that infect humans and animals. DNA extracted D. medinensis closely related infects North American carnivores, insignis, so genes coding for small-subunit ribosomal RNA (18S rRNA) parasites could be amplified, sequenced compared....

Malaria is a major public health problem in Ghana. The current strategy of the National Control Programme based on effective case management and use insecticide treated bed nets among vulnerable groups such as children under-five years age pregnant women. Resistance to pyrethroids by Anopheles gambiae s.l. funestus has been reported several African countries including neighbouring Burkina Faso. Indoor resting mosquitoes were collected. Blood-fed gravid females allowed oviposit, eggs hatched...

To compare (i) side effects associated with the simultaneous adminstration of praziquantel, albendazole and ivermectin affects only (ii) coverage by volunteers distributing three or two drugs.Two-arm comparative study in northern Ghana integrated praziquantel distribution into an existing lymphatic filariasis onchocerciasis control programme using Community Directed Distributors. The arm continued to distribute albendazole. Dosages were based on height. Treatment was directly observed, all...

This study sought to investigate microbial quality and antimicrobial resistance of bacteria species from Ready-to-Eat (RTE) food, water, vendor palm swab samples. Between 2019 2020, RTE water samples were collected food vending sites in Accra, Ghana. Samples cultured confirmed using the Matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF). Antimicrobial susceptibility testing (AST) was conducted disk diffusion method. Beta-lactamase Diarrheagenic Escherichia...

Although Hepatitis E virus (HEV) infection has significant negative impact on the health and wellbeing of underprivileged populations, burden HEV in Ghana is still unclear, despite widespread water, sanitation, hygiene (WASH) related conditions that predispose people to risk infection.A cross-sectional study was conducted explore rates seroprevalence prevalence, as well factors humans domestic pigs Ghana. These were determined using ELISAs manufactured by Wantai Beijing Biopharmaceuticals,...

The marked increase in the pig-trade Ghana has raised concerns about increased transmission of related zoonotic diseases. A study on pig-related zoonoses along pork value-chain was conducted Greater Accra and Upper East Regions Ghana. Results showed significant taenia (60%) trichinella (8%) seroprevalence pigs with little evidence to humans. Sero-prevalence HEV high both (85%) humans (37%). rates were significantly higher than Accra. Pig handlers had sero-prevalence (58%) other community...

The threats from vector-borne pathogens transmitted by ticks place people (including deployed troops) at increased risk for infection, frequently contributing to undifferentiated febrile illness syndromes. Wild and domesticated animals are critical the transmission cycle of many tick-borne diseases. Livestock can be infected ticks, serve as hosts diseases such rickettsiosis. Thus, it is necessary identify tick species determine their potential transmit pathogens. A total 1,493 adult three...

The results of analysis, by high-performance liquid chromatography coupled with electrochemical detection and nano-electrospray-ionization, double quadrupole/orthogonal-acceleration, time-of-flight mass spectrometry, indicate that adult Dracunculus medinensis Schistosoma mansoni both contain the opiate alkaloid morphine D. medinesis also contains active metabolite morphine, 6-glucuronide. From these previous observations, it would appear many helminths are probably using alkaloids as potent...

Good quality water is odourless, colourless, and free from faecal pollution, a satisfactory safe supply must be made available to consumers. The study assessed consumer preference of sachet sold consumed in the Sunyani Municipality Ghana. A cross-sectional design was used, data were collected using structured questionnaire sample size 500 respondents. total twenty (20) samples commonly also analyzed for bacteriological physicochemical parameters. Out these 20 samples, 10 production site...

Although Taenia solium infestation and cysticercosis have been documented as the main causes of acquired epilepsy their recognition important public health hazards has risen over past 10 years, there is lack information on disease burden due to Tape worm its associated risk factors in rural communities northern Ghana.This study was conducted evaluate prevalence Taeniasis document factors.The describes results a cross-sectional survey involving 494 participants, selected by villagebased...

Water bodies such as dams are known to alter the local transmission patterns of a number infectious diseases, especially those transmitted by insects and other arthropod vectors. The impact an irrigation dam on submicroscopic asexual parasite carriage in individuals living seasonal malaria area northern Ghana was investigated. A total 288 archived DNA samples from two cross-sectional surveys communities Bongo District Northern were analysed. Parasite density determined light microscopy PCR,...

Animal reservoirs of

We present, for the first time, an evaluation of treatment outcomes in a cohort at TB referral centre Central Region Ghana. Of 213 clients placed on DOTS, 59.2% (126/213) were sputum smear-positive. An overall cure rate 90.2% (51.6% cured + 37.6% completed) and death 8.5% (18/213) estimated. number who died, 5.7% (12/213) males ( χ 2 = 2.891, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn...

Objective We assessed the association of mutant allele frequencies nitric oxide synthase 2 (NOS2) gene at two SNPs (-954 and -1173) with malaria disease severity in children from a endemic area Southern Ghana. Method Using recruited hospital, assigned into clinical subgroups uncomplicated severe matching their "healthy control" counterparts, we designed case control study. Genomic DNA was extracted genotyping using Restriction Fragment Polymorphism done. Result A total 123 cases (91...

Abstract Background Ghana malaria control programme recommends the uptake of five doses sulfadoxine pyrimethamine (SP) during pregnancy following review World Health Organization recommendations in 2012. The higher SP since implementation new policy 2016, has been low across country. current study determined factors that can be improved to increase for intermittent preventive treatment (IPTp-SP). Methods A cross-sectional analytical was carried out among women who had just delivered selected...

Background: Recent studies have shown the urine filtration and Kato-Katz techniques to significantly underestimate infection intensity in Schistosoma haematobium mansoni infections, respectively. Infection determination by these methods improves only with increasing number of samples collected per participant. This implies tedious lengthy periods sample processing analysis microscopy examination, hence increased chances experimental errors. study sought determine relationship between levels...

Guinea worm disease, also known as dracunculiasis (or dracunculosis), is caused by the large female of nematode Dracunculus medinensis. It normally lives and grows in various places human body, before migrating to subcutaneous tissue eventually emerging slowly from skin, usually on lower limbs. If affected portion body comes into contact with water, first-stage juveniles (L(1)) are expelled numbers ruptured uterus. For further development, need be ingested suitable predatory species...