A5009051661- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Parasitic Diseases Research and Treatment
- Viral Infections and Outbreaks Research
- Parasite Biology and Host Interactions
- Dengue and Mosquito Control Research
- Agricultural pest management studies
- Cardiac Valve Diseases and Treatments
- Enhanced Recovery After Surgery
- Surgical site infection prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Species Distribution and Climate Change
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Pressure Ulcer Prevention and Management
- Global Health and Surgery
- Zoonotic diseases and public health
Noguchi Memorial Institute for Medical Research
2016-2025
University of Ghana
2016-2025
Piedmont Athens Regional
2024-2025
Texas Tech University Health Sciences Center
2024
Karachi Medical and Dental College
2024
Guru Gobind Singh Medical College and Hospital
2024
Liaquat University of Medical & Health Sciences
2024
Liaquat National Hospital
2024
Shaheed Mohtarma Benazir Bhutto Medical University
2024
Texas Tech University
2024
The development of resistance to insecticides has become a classic exemplar evolution occurring within human time scales. In this study we demonstrate how DDT in the major African malaria vector Anopheles gambiae is result both target-site mechanisms that have introgressed between incipient species (the M- and S-molecular forms) allelic variants DDT-detoxifying enzyme. Sequencing detoxification enzyme, Gste2, from resistant susceptible strains An. gambiae, revealed non-synonymous...
Background Yellow fever is endemic in some countries Africa, and Aedes aegpyti one of the most important vectors implicated outbreak. The mapping nation-wide distribution detection insecticide resistance vector mosquitoes will provide beneficial information for forecasting dengue yellow outbreaks effective control measures. Methodology/Principal Findings High to DDT was observed all mosquito colonies collected Ghana. possible existence or tolerance permethrin were suspected colonies....
Western Africa is vulnerable to arboviral disease transmission, having recently experienced major outbreaks of chikungunya, dengue, yellow fever and Zika. However, there have been relatively few studies on the natural history two human arbovirus vectors in this region, Aedes aegypti Ae. albopictus, potentially limiting implementation effective vector control. We systematically searched for reviewed relevant behaviour ecology albopictus Africa, published over last 40 years. identified 73...
Resistance to insecticides in Anopheles mosquitoes threatens the effectiveness of malaria control, but genetics resistance are only partially understood. We performed a large scale multi-country genome-wide association study two widely used insecticides: deltamethrin and pirimiphos-methyl, using sequencing data from An. gambiae coluzzii ten locations West Africa. was highly multi-genic, multi-allelic variable between populations. While strongest most consistent with came Cyp6aa1, this based...
Summary We studied the malaria transmission dynamics in Kassena Nankana district (KND), a site northern Ghana proposed for testing vaccines. Intensive mosquito sampling 1 year using human landing catches three micro‐ecological sites (irrigated, lowland and rocky highland) yielded 18 228 mosquitoes. Anopheles gambiae s.l. funestus constituted 94.3% of total collection with 76.8% captured from irrigated communities. Other species collected but relatively few numbers were pharoensis (5.4%)...
Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction effective insecticides, such as the organophosphate pirimiphos-methyl, essential overcome recurrent emergence resistance driven by highly diverse Anopheles genomes. Here, we use genomic approach investigate basis pirimiphos-methyl major vectors gambiae and A . coluzzii combination copy number variation single non-synonymous substitution...
Ticks are important vectors of various pathogenic protozoa, bacteria and viruses that cause serious life-threatening illnesses in humans animals worldwide. Estimating tick-borne pathogen prevalence tick populations is necessary to delineate how geographical differences, environmental variability host factors influence transmission. This study identified ticks pathogens samples collected from June 2016 December 2017 at seven sites within the Coastal, Sudan Guinea savanna ecological zones...
Aedes aegypti (Linnaeus, 1762) is the main mosquito vector for dengue and other arboviral infectious diseases. Control of this important highly relies on use insecticides, especially pyrethroids. The high frequency (>78%) L982W substitution was detected at target site pyrethroid insecticide, voltage-gated sodium channel (Vgsc) A. collected from Vietnam Cambodia. Alleles having concomitant mutations + F1534C V1016G were also confirmed in both countries, their (>90%) Phnom Penh, Strains these...
Malaria vector control methods involving the use of pyrethroids remain strategies being used against malaria vectors in Ghana. These include long-lasting insecticidal nets and indoor residual spraying many areas However, there is evidence that pyrethroid resistance widespread Synergists have been shown to be useful inhibiting enzymes are responsible for development hence enhance insecticide susceptibility Anopheles gambiae sensu lato (s.l.) areas. The present study investigated effect...
Insecticide resistance of Anopheles gambiae (s.l.) against public health insecticides is increasingly reported in Ghana and need to be closely monitored. This study investigated the intensity insecticide An. found a vegetable growing area Accra, Ghana, where insecticides, herbicides fertilizers are massively used for plant protection. The bioefficacy long-lasting insecticidal nets (LLINs) currently distributed country was also assessed delimitate impact on effectiveness those nets.Three-...
The primary control methods for the African malaria mosquito, Anopheles gambiae, are based on insecticidal interventions. Emerging resistance to these compounds is therefore of major concern programs. organophosphate (OP), pirimiphos-methyl, a relatively new chemical in vector armory but now widely used indoor-residual spray campaigns. While generally effective, phenotypic has developed some areas vectors. Here, we population genomic approach identify novel mechanisms pirimiphos-methyl A....
Ticks continue to invade new regions spreading pathogens of zoonotic and veterinary importance. Diverse tick species have been reported in Ghana due the continuous trade livestock. In this study, ticks were collected from cattle three sites within Southern Ghana. The 1489 morphologically identified further confirmed using a molecular assay that amplifies 660-bp segment mitochondrial cytochrome c oxidase subunit 1 (COI) gene. These pooled screened for From 215 pools screened, Rickettsia DNA...
Background: Current guidelines for ischemic stroke recommend initiating intravenous thrombolytic therapy within 4.5 hours after onset or the last known well time. However, advancements in imaging techniques, such as CT perfusion and perfusion-diffusion magnetic resonance (MRI), have improved diagnostic accuracy. These modalities can identify viable brain tissue beyond 4.5-hour window, reperfusion through thrombolysis has been shown to enhance functional outcomes patients with salvageable...
Ghana’s lymphatic filariasis (LF) elimination was intensified by Global Programme to Eliminate Lymphatic in 2000. LF transmission interrupted some endemic district, yet, persistent others. This study investigated characteristics of Wuchereria bancrofti that potentially contribute districts after prolonged mass chemotherapy (≧15yrs) expected interrupt transmission. Participants’ finger-prick blood screened for antigenaemia and positives followed night detect microfilariae. The...
Indoor residual spraying (IRS) is being implemented as one of the malaria prevention methods in Northern Region Ghana. Changes longevity, sporozoite and entomological inoculation rates (EIRs) major vectors were monitored to assess impact IRS selected districts. Monthly human landing catches (HLCs) used collect mosquitoes from sentinel sites three adjacent districts between July 2009 December 2014: Savelugu Nanton (SND) where had been 2008 2014; Tolon Kumbungu (TKD) 2012 Tamale Metropolis...
Abstract Aedes aegypti (L.) (Diptera: Culicidae) is a diurnal feeder that lives in close association with human populations. It the principal vector of yellow fever, dengue fever and Zika Virus. Issues arboviral diseases have been on ascendency most countries including Ghana where mosquito main fever. A comparative study biting behavior Ae. identification subspecies were undertaken using molecular technique. Standard landing technique was used to collect both indoor outdoor mosquitoes at...
High-malaria burden countries in sub-Saharan Africa are shifting from malaria control towards elimination. Hence, there is need to gain a contemporary understanding of how indoor residual spraying (IRS) with non-pyrethroid insecticides when combined long-lasting insecticidal nets (LLINs) impregnated pyrethroid insecticides, contribute the efforts National Malaria Control Programmes interrupt transmission and reduce reservoir Plasmodium falciparum infections across all ages. Using an...
The Global Programme to Eliminate Lymphatic Filariasis was launched in 2000 with the goal of interrupting transmission lymphatic filariasis (LF) through multiple rounds mass drug administration (MDA). In Guinea, there is evidence ongoing LF transmission, but little known about most densely populated parts country, including capital Conakry. order guide control and elimination efforts, serological entomological surveys were carried out determine whether or not occurs prevalence circulating...
The increasing spread of insecticide resistance in malaria vectors has been well documented across sub-Saharan Africa countries. influence irrigation on vector is poorly understood, and critical to successful ethical implementation food security policies. This study investigated the status An. gambiae (s.l.) mosquitoes collected from irrigated rice area Okyereko, a village containing about 42 hectares field within an project plan Central Region Ghana. Large amounts insecticides, herbicides...
Entomological surveillance is one of the tools used in monitoring and controlling vector-borne diseases. However, use entomological for arboviral infection vector control often dependent on finding infected individuals. Although this method may suffice highly endemic areas, it not as effective spread diseases low non-endemic areas. In study, we examined efficiency using markers to assess status risk arbovirus Ghana, which considered a country, by combining mosquito with virus isolation...