A5048009309- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Pest Control Strategies
- CRISPR and Genetic Engineering
- Insect Resistance and Genetics
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Genetics, Bioinformatics, and Biomedical Research
- Global Maternal and Child Health
- Viral Infections and Vectors
- Agriculture and Rural Development Research
- Viral Infections and Outbreaks Research
- Adolescent Sexual and Reproductive Health
- Maternal and Perinatal Health Interventions
- Poverty, Education, and Child Welfare
- Invertebrate Immune Response Mechanisms
- Insect and Pesticide Research
- Uterine Myomas and Treatments
- HIV/AIDS Research and Interventions
- Gynecological conditions and treatments
- Maternal and fetal healthcare
- Dengue and Mosquito Control Research
- Biotechnology and Related Fields
- Computational Drug Discovery Methods
- Parasitic Diseases Research and Treatment
Mali-Folkecenter
2020-2024
Université des Sciences, des Techniques et des Technologies de Bamako
2012-2024
Institut National de Recherche en Santé Publique
2024
Credo Reference (United States)
2024
Health Center
2024
United Nations Children's Fund Niger
2023
Sightsavers
2023
University of Bamako
2008-2021
National Institute of Malaria Research
2021
Community Health Center
2021
Western Africa is vulnerable to arboviral disease transmission, having recently experienced major outbreaks of chikungunya, dengue, yellow fever and Zika. However, there have been relatively few studies on the natural history two human arbovirus vectors in this region, Aedes aegypti Ae. albopictus, potentially limiting implementation effective vector control. We systematically searched for reviewed relevant behaviour ecology albopictus Africa, published over last 40 years. identified 73...
Despite impressive progress, malaria continues to impose a substantial burden of mortality and morbidity, particularly in sub-Saharan Africa, new tools will be needed achieve elimination. Gene drive is natural process by which some genes are inherited at greater-than-Mendelian rate can spread through population even if they cause harm the organisms carrying them. Many different synthetic gene systems have been proposed suppress number mosquitoes and/or reduce vector competence. As with any...
Bioinformatics and data science research has boundless potential across Africa due to its high levels of genetic diversity disproportionate burden infectious diseases, including malaria, tuberculosis, HIV/AIDS, Ebola virus disease, Lassa fever. This work lays out an incremental training approach for engaging underserved populations in bioinformatics at the University Sciences, Techniques Technologies Bamako, Mali (USTTB). Two informatics programs sponsored by Fogarty International Center...
A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens symbionts express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly, there still a paucity effector molecules with potent anti-malaria activity whose expression does not cause detrimental effects on fitness. Our objective was examine wide range antimicrobial peptides (AMPs) for their toxic Plasmodium and anopheline...
Background Anopheles funestus is one of the major malaria vectors in Africa and yet there are few genomic tools available for this species compared to An. gambiae. To start close knowledge gap, we sequenced transcriptome using cDNA libraries developed from a pyrethroid resistant laboratory strain susceptible field Mali. Results Using pool life stages (pupae, larvae, adults: females males) each strain, 454 sequencing generated 375,619 reads (average length 182 bp). De novo assembly 18,103...
Mosquito feeding assays play an important role in quantifying malaria transmission potential epidemiological and clinical studies. At present, membrane are incompletely standardised. This affects our understanding of the precision assay its suitability for evaluating transmission-blocking interventions. Here, we present a detailed protocol using
Malaria remains a pervasive public health problem in sub-Saharan West Africa. Here mosquito vector populations were explored across four sites Mali and the Republic of Guinea (Guinea Conakry). The study samples major ecological zones malaria-endemic regions Africa within relatively small distance. Mosquito vectors sampled from larval pools, adult indoor resting sites, outdoor human-host seeking adults. Mosquitoes collected at spanning 350 km that represented arid savannah, humid semi-forest...
Abstract Malaria is the leading cause of morbidity and mortality in Mali. Between 2017 2020, number cases increased country, with 2,884,827 confirmed 1454 reported deaths 2020. We performed a malaria risk stratification at health district level Mali view to proposing targeted control interventions. Data on were obtained from District Health Information Software 2, data prevalence children aged 6–59 months 2018 Demographic Survey, entomological Malian research institutions working sentinel...
Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, series online workshops nine recommendations to advance future environmental risk assessment applications.
Indoor residual spraying (IRS) is a primary method of malaria vector control, but its potential impact constrained by several inherent limitations: must be repeated when insecticide residues decay, householders can tire the annual imposition and campaign costs are recurrent. Durable lining (DL) considered an advanced form long-lasting IRS where gradually released from aesthetically attractive wall material to provide control for years. A multicentre trial was carried out in Equatorial...
The unprecedented global efforts for malaria elimination in the past decade have resulted altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities transmission require innovative control strategies addition to established practices of long-lasting insecticidal nets indoor residual spraying. Integrated management will focal tailored achieve elimination. This switch emphasis from universal coverage plus additional...
The past 40 years have seen a dramatic emergence of epidemic arboviral diseases transmitted primarily by mosquitoes. frequency and magnitude the epidemics, especially those urban Aedes species, progressively increased over time, accelerating in 10 years. To reduce burden threat vector-borne diseases, World Health Organization (WHO) has recently adopted Global Vector Control Response (GVCR) order to support countries implementing effective sustainable vector control. evidence-base control is...
Over the past decade, three strategies have reduced severe malaria cases and deaths in endemic regions of Africa, Asia Americas, specifically: (1) artemisinin-based combination therapy (ACT); (2) insecticide-treated bed nets (ITNs); and, (3) intermittent preventive treatment with sulfadoxine-pyrimethamine pregnancy (IPTp). The rationale for this study was to examine communities Dangassa, Mali where, 2015, two additional control were implemented: ITN universal coverage seasonal...
Malaria parasite infectivity to mosquitoes has been measured in a variety of ways and setting, includind direct feeds and/or membrane feeding blood collected from randomly selected or gametocytemic volunteers. Anopheles gambiae s.l is the main vector responsible Plasmodium falciparum transmission Bancoumana represents about 90% laboratory findings, whereas malariae ovale together represent only 10%. Between August 1996 December 1998, methods were compared for children adolescent gametocyte...
Background: Dengue viruses (DENV) are endemic in over 100 countries worldwide, and annually 50 to million people infected by one of the four DENV serotypes, whereas 2.5 billion at risk for infection. West African lack surveillance determine true incidence dengue; hence, this disease is likely significantly underestimated. In Mali, ∼14 potentially acquiring a dengue Methods Findings: A serosurvey was conducted on 95 human serum samples obtained from Institute National de Recherche en Sante...