A5068007157- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Computational Drug Discovery Methods
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Pharmaceutical Practices and Patient Outcomes
- Child Nutrition and Water Access
- Fish Biology and Ecology Studies
- Hepatitis C virus research
- Vector-borne infectious diseases
- Immune responses and vaccinations
- Iron Metabolism and Disorders
- Gout, Hyperuricemia, Uric Acid
- Gut microbiota and health
- Drug-Induced Hepatotoxicity and Protection
- Vaccine Coverage and Hesitancy
- Trypanosoma species research and implications
- Complement system in diseases
- Genetic Mapping and Diversity in Plants and Animals
Université des Sciences, des Techniques et des Technologies de Bamako
2016-2025
University of Bamako
2012-2024
Centre Hospitalier Universitaire de Tours
2024
Centre for Human Genetics
2023
University of Oxford
2023
Department of Health Research
2023
National Institute of Malaria Research
2020
National Institutes of Health
2016
Corgenix (United States)
2016
Tulane University
2016
<ns3:p>We describe the MalariaGEN Pf7 data resource, seventh release of <ns3:italic>Plasmodium falciparum</ns3:italic> genome variation from network. It comprises over 20,000 samples 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For first time we include dried blood spot sequenced after selective whole amplification, necessitating new methods to genotype copy number variations. We identify a large newly emerging...
Background. Artemisinin resistance, a long parasite clearance half-life in response to artemisinin, has been described patients with Plasmodium falciparum malaria southeast Asia. Few baseline half-lives have reported from Africa, where artemisinins were recently introduced. Methods. We treated P. 215 Malian children aged 0.5–15 years artesunate (0, 24, 48 hours) and amodiaquine (72, 96, 120 hours). estimated by measuring density every 6 hours until undetectable evaluated the effects of age,...
<title>Abstract</title> <bold>Background</bold>. Health workers (HWs) are at high risk of SARS-CoV-2 infection due to their frontline role and considered as priority group for COVID-19 vaccination. This study aimed estimate incidence rates identify the factors among HWs in Mali strengthen prevention measures. <bold>Method</bold>. A cohort 1098 was conducted from November 2021 February 2023, six health centers two university hospitals Bamako. Sociodemographic clinical data, nasopharyngeal...
Background Ps 48/45, a Plasmodium gametocyte surface protein, is promising candidate for malaria transmission-blocking (TB) vaccine. Due to its relevance multispecies vaccine, we explored the cross-reactivity and TB activity of recombinant P. vivax 48/45 protein (r Pvs 48/45) with plasma from falciparum -exposed African donors. Methods r was produced in Chinese hamster ovary cell lines tested by ELISA Burkina Faso, Tanzania, Mali, Nigeria. In addition, BALB/c mice were immunized formulated...
Background α-thalassemia results from decreased production of α-globin chains that make up part hemoglobin tetramers (Hb; α2β2) and affects to 50% individuals in some regions sub-Saharan Africa. Heterozygous (−α/αα) homozygous (−α/−α) genotypes are associated with reduced risk severe Plasmodium falciparum malaria, but the mechanism this protection remains obscure. We hypothesized impairs adherence parasitized red blood cells (RBCs) microvascular endothelial (MVECs) monocytes – two...
Background Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another hypoxanthine xanthine, accumulate in parasitized red blood cells (RBCs) may be converted by plasma xanthine oxidase to UA at schizont rupture. These two forms ‘parasite-derived’ stimulate immune produce...
Drug resistance is one of the greatest challenges malaria control programme in Mali. Recent advances next-generation sequencing (NGS) technologies provide new and effective ways tracking drug-resistant parasites Africa. The diversity prevalence Plasmodium falciparum drug-resistance molecular markers were assessed Dangassa Nioro-du-Sahel Mali, two sites with distinct transmission patterns. has an intense seasonal transmission, whereas unstable short transmission.Up to 270 dried blood spot...
Abstract Background Seasonal malaria chemoprevention (SMC) is a new strategy to prevent in children under 5 years old. It has been recommended by the World Health Organization since 2012 malaria-endemic areas with seasonal transmission. This study aimed assess changes indicators through two consecutive of SMC routine implementation old Dangassa, where endemic long and high transmission season. Methods From 2016, cohort was conducted Dangassa village. The team based village followed all...
This study was conducted to determine the efficacy of antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, treat Schistosoma haematobium school aged children.The Djalakorodji, a peri-urban area Bamako, Mali, using double blind setup which As+SMP compared with praziquantel (PZQ). Urine samples were examined on days -1, 0, 28 and 29. Detection haematuria, haematological biochemical exams day 0...
Lassa virus (LASV) is endemic to several nations in West Africa. In Mali, LASV was unknown until an exported case of fever reported 2009. Since that time, rodent surveys have found evidence LASV-infected Mastomys natalensis rats communities southern near the border with Côte d'Ivoire. Despite increased awareness, date only a single has been confirmed Mali. We conducted survey determine prevalence exposure among persons 3 villages Mali where presence infected rodents documented. IgG...
Over the past decade, three strategies have reduced severe malaria cases and deaths in endemic regions of Africa, Asia Americas, specifically: (1) artemisinin-based combination therapy (ACT); (2) insecticide-treated bed nets (ITNs); and, (3) intermittent preventive treatment with sulfadoxine-pyrimethamine pregnancy (IPTp). The rationale for this study was to examine communities Dangassa, Mali where, 2015, two additional control were implemented: ITN universal coverage seasonal...
Despite a significant reduction in the burden of malaria children under five years-old, efficient implementation seasonal chemoprevention (SMC) at large scale remains major concern areas with long transmission. Low coverage rate unattainable during rainy season, shift risk to older and rebound incidence after stopping drug administration are mainly reported these areas. These gaps represent challenge SMC measures. An open randomized study was conducted assess effect fifth additional round...
48/45, a
Background Inflammatory cytokinemia and systemic activation of the microvascular endothelium are central to pathogenesis Plasmodium falciparum malaria. Recently, 'parasite-derived' uric acid (UA) was shown activate human immune cells in vitro, plasma UA levels were associated with inflammatory cytokine disease severity Malian children Since is endothelial inflammation non-malaria diseases, we hypothesized that elevated contribute pathology P. Methodology/Principal Findings We measured...
Abstract Background Implementation and upscale of effective malaria vector control strategies necessitates understanding the multi-factorial aspects transmission patterns. The primary aims this study are to determine composition, biting rates, trophic preference, overall importance distinguishing outdoor versus indoor through a at two communities in rural Mali. Methods Mosquito collection was carried out between July 2012 June 2016 Mali (Dangassa Koïla Bamanan) using pyrethrum spray-catch...
ABSTRACT. Seasonal malaria chemoprevention (SMC) was adopted in Mali 2012 for preventing children younger than 5 years. Although this strategy has been highly effective reducing childhood malaria, an uptick occurrence occurred to 15 years of age. This study aimed investigate the feasibility providing SMC older children. A cohort 350 age 14 were monitored during 2019 transmission season Dangassa, Mali. The intervention group received five monthly rounds sulfadoxine–pyrimethamine plus...
Malaria transmission largely depends on environmental, climatic, and hydrological conditions. In Mali, malaria epidemiological patterns are nested within three ecological zones. This study aimed at assessing the relationship between those conditions incidence of in Dangassa Koila, Mali. data was collected through passive case detection community health facilities each site from June 2015 to January 2017. Climate environmental were obtained over same time period Goddard Earth Sciences...
Despite the global interest and unprecedented number of scientific studies triggered by COVID-19 pandemic, few data are available from developing low-income countries. In these regions, communities live under threat various transmissible diseases aside COVID-19, including malaria. This study aims to determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroreactivity antibodies pre-COVID-19 samples individuals in Mali (West Africa). Blood patients (n = 266) at Bamako...
Sickle-cell trait (HbAS) reduces falciparum malaria risk and suppresses parasitaemia. Although several candidate mechanisms have been proposed, their epidemiological, clinical experimental correlates not adequately explained. To explore the basis for generally lower parasitaemias delayed episodes in children with HbAS, it is hypothesized here that spleen-dependent removal of ring-infected red blood cells (RBCs) more efficient than normal haemoglobin A (HbAA).The mechanical splenic retention...
The currently devastating pandemic of severe acute respiratory syndrome known as coronavirus disease 2019 or COVID-19 is caused by the SARS-CoV-2. Both virus and have been extensively studied worldwide. A trimeric spike (S) protein expressed on outer bilayer leaflet has identified a ligand that allows to penetrate human host cells cause infection. Its receptor-binding domain (RBD) interacts with angiotensin-converting enzyme 2 (ACE2), host-cell viral receptor, is, therefore, subject intense...
Introduction : Les traumatismes oculaires représentent des pathologies très fréquentes en ophtalmologie. Le caractère variable de leur circonstance survenu souvent inconnu et la diversité lésions résultantes ces peut rendre prise charge délicate. Seul un interrogatoire détaillé examen ophtalmologique minutieux peuvent garantir bon pronostic. but cette étude était faire une analyse étiologique topographique traumatiques au CHU Kati. Méthodologie Il s’est agi d’un rétrospective transversale...