A5034456354- Malaria Research and Control
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Global Maternal and Child Health
- COVID-19 epidemiological studies
- Parasites and Host Interactions
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Adolescent Sexual and Reproductive Health
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- HIV/AIDS Research and Interventions
- Travel-related health issues
- CRISPR and Genetic Engineering
- Aquaculture disease management and microbiota
- HIV/AIDS oral health manifestations
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Immune responses and vaccinations
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
Instituto Nacional de Saúde
2014-2024
Instituut voor Tropische Geneeskunde
2018-2019
University of Antwerp
2018-2019
Research Institute for Tropical Medicine
2018
Ministry of Health
2013
<ns3:p>We describe the MalariaGEN Pf7 data resource, seventh release of <ns3:italic>Plasmodium falciparum</ns3:italic> genome variation from network. It comprises over 20,000 samples 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For first time we include dried blood spot sequenced after selective whole amplification, necessitating new methods to genotype copy number variations. We identify a large newly emerging...
While the
Background Malaria remains a significant health problem in Mozambique, particularly the case of pregnant women and children less than five years old. Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP) is recommended for preventing malaria pregnancy (MiP). Despite widespread use cost-effectiveness IPTp-SP, coverage low. In this study, we explored factors limiting access to IPTp-SP rural part Mozambique. Methods findings We performed qualitative study using...
Background Reliable HIV incidence estimates for Mozambique are limited. We conducted a prospective study as part of clinical research site development initiative in Chókwè district, Gaza Province, southern Mozambique. Methods Between June 2010 and October 2012, we recruited women at sites where higher risk infection would likely be found. enrolled tested 1,429 sexually active the screening phase 479 uninfected phase. Participants were scheduled 12+ months follow-up, when they underwent...
Malaria in pregnancy leads to serious adverse effects on the mother and child accounts for 75,000-200,000 infant deaths every year. Currently, World Health Organization recommends intermittent preventive treatment of malaria (IPTp) with sulfadoxine-pyrimethamine (SP) at each scheduled antenatal care (ANC) visit. This study aimed assess IPTp-SP coverage mothers delivering health facilities community. In addition, factors associated low uptake outcomes were investigated.A community a...
Introduction Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims operationalise functional malaria molecular system Mozambique for guiding control and elimination. Methods analyses prospective seeks generate Plasmodium falciparum genetic (1) monitor markers drug resistance deletions rapid diagnostic test targets; (2) characterise...
Mozambique reported the first case of coronavirus disease 2019 (COVID-19) in March 2020 and it has since spread to all provinces country. To investigate introductions SARS-CoV-2 Mozambique, 1 142 whole genome sequences sampled within were phylogenetically analyzed against a globally representative set, reflecting 25 months epidemic. The epidemic country was marked by four waves infection, associated with B.1 ancestral lineages, while Beta, Delta, Omicron Variants Concern (VOCs) responsible...
Acute diarrhea disease caused by Rotaviruses A (RVA) is still the leading cause of morbidity and mortality in children ≤5 years old developing countries. An exploratory cross‐sectional study was conducted between February September, 2011 to determine proportion acute RVA. total 254 stool specimens were collected from with diarrhea, including outpatients (222 children) inpatients (32 children), three local health centers Chókwè District, Gaza Province, South Mozambique. RVA antigens detected...
Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is world's fourth largest contributor, with 4.7% disease cases 3.6% total deaths due to malaria. Its control relies on fight against vector treatment confirmed anti-malarial drugs. Molecular surveillance an important tool for monitoring spread drug resistance.A cross-sectional study recruited 450 participants malaria infection detected by Rapid Diagnostic Tests, from three different sites...
Introduction Malaria molecular surveillance has the potential to generate information on biological threats that compromise effectiveness of antimalarial interventions. This study aims streamline activities inform new strategic plan Mozambican National Control Programme (2023–2030) for malaria control and elimination. Methods analyses prospective genomic Plasmodium falciparum genetic data monitor diagnostic failures due pfhrp2/3 deletions markers drug resistance, characterise transmission...
Abstract Background The extent of population exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was uncertain in many African countries during the onset pandemic. Methods We conducted a cross-sectional study and randomly selected surveyed general occupational groups from 6 July 24 August 2020, 3 cities Mozambique. Anti–SARS-CoV-2–specific immunoglobulin M (IgM) G (IgG) antibodies were measured using point-of-care rapid test. prevalence weighted for (by age, sex, city)...
<ns3:p>Introduction Malaria molecular surveillance has the potential to generate information on biological threats that compromise effectiveness of antimalarial interventions. This study aims streamline activities inform new strategic plan Mozambican National Control Program (2023-2030) for malaria control and elimination. Methods analyses prospective genomic <ns3:italic>P. falciparum</ns3:italic> genetic data monitor diagnostic failures due <ns3:italic>pfhrp2/3</ns3:italic> deletions...
Abstract Background: Malaria is still a leading cause of morbidity and mortality among children under five years old in Mozambique. In this study we sought to determine the prevalence malaria infection its predictors six 59 months Methods: Data from two national indicators surveys 2015 2018 were compared. both surveys, blood samples collected detect Plasmodium falciparum antigen by rapid diagnostic test, questionnaires applied collect socio-economic, demographic vector control data their...
Abstract Malaria remains one of the most serious public health problem in sub-Saharan Africa and Mozambique is world's fourth largest contributor, with 4.7% disease cases 3.6% total deaths due to malaria. Its control relies on fight against vector treatment confirmed antimalarial drugs. Molecular surveillance important tool for monitoring spread drug resistance. A cross-sectional study recruited 450 participants malaria infection detected by Rapid Diagnostic Test, from three different sites...
Abstract Background Malaria remains a significant health problem in Mozambique, particularly to pregnant women and children less than five years old. Intermittent preventive treatment is recommended for malaria prevention pregnancy (IPTp). Despite the widespread use cost-effectiveness of this intervention, coverage low. In study, we aimed explore factors limiting access IPTp-SP Chókwè district. Methods findings We used qualitative research methods through semi-structured interviews collect...