Alexandra Wharton–Smith

ORCID: 0000-0001-5335-2059
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About
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Research Areas
  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Global Maternal and Child Health
  • Emergency and Acute Care Studies
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Respiratory viral infections research
  • Pneumonia and Respiratory Infections
  • Sepsis Diagnosis and Treatment
  • Data-Driven Disease Surveillance
  • Respiratory Support and Mechanisms
  • Vaccine Coverage and Hesitancy
  • COVID-19 and healthcare impacts
  • Viral Infections and Outbreaks Research
  • Parasites and Host Interactions
  • Disaster Response and Management
  • Employment and Welfare Studies
  • Influenza Virus Research Studies
  • Tuberculosis Research and Epidemiology
  • Zoonotic diseases and public health
  • Dengue and Mosquito Control Research
  • Ethics in Clinical Research
  • Child Nutrition and Water Access
  • Family and Patient Care in Intensive Care Units
  • Migration, Health and Trauma
  • Chronic Disease Management Strategies

London School of Hygiene & Tropical Medicine
2019-2025

Faculty of Public Health
2020-2025

Tsinghua University
2024

Mahidol Oxford Tropical Medicine Research Unit
2023

Malaria Consortium
2014-2022

Cambodia National Malaria Center
2017-2021

Médecins Sans Frontières‎
2021

Public Health England
2020

Background Globally, critical illness results in millions of deaths every year. Although many these are potentially preventable, the basic, life-saving care critically ill patients often overlooked health systems. Essential Emergency and Critical Care (EECC) has been devised as that should be provided to all hospitals world. EECC includes effective low cost complexity for identification treatment across medical specialties. This study aimed specify content additionally, given surge ongoing...

10.1136/bmjgh-2021-006585 article EN cc-by BMJ Global Health 2021-09-01

Despite known gender-specific differences in terms of prevalence, transmission and exposure to neglected tropical diseases (NTDs), there is limited discussion the influence gender NTD programmes interventions. There a paucity research on how interacts with service provision uptake. This study, part broader implementation Ethiopia, applied lens health seeking for five NTDs: lymphatic filariasis, podoconiosis, schistosomiasis, soil-transmitted helminth infection trachoma.The study was...

10.1371/journal.pntd.0007840 article EN cc-by PLoS neglected tropical diseases 2019-12-12

Aim To explore healthcare providers’ perceptions and experiences of the implications a patient data-sharing agreement between National Health Service (NHS) Digital Home Office on access to NHS services quality care received by migrant patients in England. Design A qualitative study using semi-structured interviews, thematic analysis constant-comparison approach. Participants Eleven providers one non-clinical volunteer working community or hospital-based settings who had experience migrants...

10.1136/bmjopen-2019-033202 article EN cc-by BMJ Open 2020-02-01

Numerous studies highlight the effectiveness of an integrated approach for management malaria, pneumonia and diarrhoea at community level. There has however been little study on lessons learnt from implementation in practice stakeholder experiences which could inform future programmatic planning evaluation frameworks. A participatory, qualitative was conducted three varied settings South Sudan, Uganda Zambia, have seen scale up case (iCCM) over last five years. All key in-country...

10.7189/jogh.04.020404 article EN cc-by Journal of Global Health 2014-12-01

Background: Pneumonia heavily contributes to global under-five mortality. Many countries use community case management detect and treat childhood pneumonia. Community health workers (CHWs) have limited tools help them assess signs of New respiratory rate (RR) counting devices pulse oximeters are being considered for this purpose.Objective: To explore perspectives CHWs national stakeholders regarding the potential usability scalability seven aid assessment pneumonia signs.Design: Pile sorting...

10.1080/16549716.2017.1290340 article EN cc-by Global Health Action 2017-01-01

Introduction Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims operationalise functional malaria molecular system Mozambique for guiding control and elimination. Methods analyses prospective seeks generate Plasmodium falciparum genetic (1) monitor markers drug resistance deletions rapid diagnostic test targets; (2) characterise...

10.1136/bmjopen-2022-063456 article EN cc-by BMJ Open 2022-07-01

Low blood oxygen saturation (SpO2), or hypoxaemia, is an indicator of severe illness in children. Pulse oximetry a globally accepted, non-invasive method to identify but rarely available outside higher-level facilities resource-constrained countries. This study aims evaluate the performance different types pulse oximeters amongst frontline health workers Cambodia, Ethiopia, South Sudan, and Uganda.Five (POx) which passed laboratory testing, out initial 32 potential oximeters, were evaluated...

10.1016/j.eclinm.2021.101040 article EN cc-by EClinicalMedicine 2021-07-23

Once a mainstay of malaria elimination operations, larval source management (LSM)-namely, the treatment mosquito breeding habitats-has been marginalized in Africa favour long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). However, development new technologies, mosquitoes' growing resistance to insecticides used LLINs IRS raise renewed interest LSM.A digitally managed larviciding (DML) operation three seven districts São Tomé Príncipe (STP) was launched by Ministry...

10.1186/s12936-023-04543-0 article EN cc-by Malaria Journal 2023-04-06

Malaysia has rising dengue incidence. World Health Organization clinical practice guidelines for managing have been adapted by the Ministry of in Malaysia, with evidence good awareness clinicians. However, mortality not reduced. This study aimed to explore challenges management Medical Officers, a particular focus on use guidelines.Qualitative using six groups and 14 semi-structured interviews doctors responsible at large tertiary hospital Malaysia.Dengue was recognised as difficult diagnose...

10.1186/s12879-019-3680-5 article EN cc-by BMC Infectious Diseases 2019-01-11

Background Malaria is a significant cause of morbidity and mortality in children aged under 5 years Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration four monthly courses sulfadoxine-pyrimethamine (SP) amodiaquine (AQ), to 3-59 months during rainy season. However, as resistance SP widespread East Southern Africa, SMC has so far only been implemented across Sahel West Africa. Objective This protocol describes first phase pilot...

10.2196/27855 article EN cc-by JMIR Research Protocols 2021-05-12

Cambodia has one of the highest dengue infection rates in Southeast Asia. Here we report quantitative entomological results a large-scale cluster-randomised trial assessing impact on vector populations package control interventions including larvivorous guppy fish household water containers, mosquito trapping with gravid-ovitraps, solid waste management, breeding-container coverage through community education and engagement for behavioural change, particularly participation school children....

10.1371/journal.pntd.0010028 article EN cc-by PLoS neglected tropical diseases 2022-01-25

Pneumonia is one of the leading causes death in children aged under 5 years both sub-Saharan Africa and Southeast Asia. The current diagnostic criterion for pneumonia based on increased respiratory rate (RR) with cough or difficulty breathing. Low oxygen saturation, measured using pulse oximeters, indicative severe pneumonia. Health workers often find it difficult to accurately count number breaths, RR counting devices are use unavailable. Nonetheless, improved low-cost oximeters now...

10.2196/10191 article EN cc-by JMIR Research Protocols 2018-07-04

Abstract Background Globally, critical illness results in millions of deaths every year. Although many these are potentially preventable, the basic, life-saving care critically ill patients often overlooked health systems. Essential Emergency and Critical Care (EECC) has been devised as that should be provided to all hospitals world. EECC includes effective low cost complexity for identification timely treatment across medical specialities. This study aimed specify content additionally,...

10.1101/2021.03.18.21253191 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2021-03-20

During the early stages of COVID-19 pandemic, concerns were raised about reduced attendance at hospitals, particularly in paediatric emergency departments, which could result preventable poorer outcomes and late presentations among children requiring care. We aimed to investigate impact on health-seeking behaviour decision-making processes caregivers presenting services a National Health Service (NHS) Trust London.We conducted mixed-methods study (survey semi-structured interviews) across...

10.1371/journal.pone.0276055 article EN cc-by PLoS ONE 2022-11-16

<title>Abstract</title> <bold>Background</bold> Seasonal malaria chemoprevention (SMC) is a World Health Organization-recommended intervention for the prevention of among children at high risk in areas with seasonal transmission. During coronavirus disease 2019 (COVID-19) pandemic, SMC drug distribution was rapidly adapted to reduce contact and mitigate transmission between communities community distributors, caregivers administering doses. To address challenges find local solutions improve...

10.21203/rs.3.rs-4094402/v1 preprint EN cc-by Research Square (Research Square) 2024-03-19

Seasonal malaria chemoprevention (SMC) is a World Health Organization-recommended intervention for the prevention of among children at high risk in areas with seasonal transmission. During coronavirus disease 2019 (COVID-19) pandemic, SMC drug distribution was rapidly adapted to reduce contact and mitigate transmission between communities community distributors, caregivers administering doses. To address challenges find local solutions improve administration adherence, role model approach...

10.1186/s12936-024-05067-x article EN cc-by-nc-nd Malaria Journal 2024-08-24

<sec> <title>BACKGROUND</title> Malaria is a significant cause of morbidity and mortality in children aged under 5 years Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration four monthly courses sulfadoxine-pyrimethamine (SP) amodiaquine (AQ), to 3-59 months during rainy season. However, as resistance SP widespread East Southern Africa, SMC has so far only been implemented across Sahel West Africa. </sec> <title>OBJECTIVE</title>...

10.2196/preprints.27855 preprint EN 2021-02-09

<sec> <title>BACKGROUND</title> Pneumonia is one of the leading causes death in children aged under 5 years both sub-Saharan Africa and Southeast Asia. The current diagnostic criterion for pneumonia based on increased respiratory rate (RR) with cough or difficulty breathing. Low oxygen saturation, measured using pulse oximeters, indicative severe pneumonia. Health workers often find it difficult to accurately count number breaths, RR counting devices are use unavailable. Nonetheless,...

10.2196/preprints.10191 preprint EN 2018-03-08

Background: Pneumonia is one of the leading causes death in children under-five globally. The current diagnostic criteria for pneumonia are based on increased respiratory rate (RR) or chest in-drawing with cough and/or difficulty breathing. Counting RR difficult community health workers (CHWs). Current counting devices frequently inadequate unavailable. This study analysed performance improved timers detection symptoms low-resource settings. Methods: Four were evaluated 454 over three months...

10.2139/ssrn.3323109 article EN SSRN Electronic Journal 2019-01-01

Background: Dengue is estimated to pose a risk half of the world's population and represents significant global economic burden. In Malaysia, dengue major cause morbidity infectious disease mortality, with an annual upward trend in nationally reported cases. The identification patients upon presentation, specifically, diagnosis, classification management cases, can be challenging due wide spectrum manifestation. Current case definitions classifications difficult apply practice. Often,...

10.1016/j.ijid.2020.11.103 article EN cc-by-nc-nd International Journal of Infectious Diseases 2020-12-01
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