Laura Donovan
A5053780498- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Malaria Research and Control
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Global Maternal and Child Health
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- COVID-19 epidemiological studies
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Palliative Care and End-of-Life Issues
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
Malaria Consortium
2020-2025
Hospital for Sick Children
2014-2024
Great Ormond Street Hospital
2021-2024
University College London
2021-2024
Columbia University Irving Medical Center
2015-2024
New York Hospital Queens
2018-2023
Columbia University
2016-2023
NewYork–Presbyterian Hospital
2016-2023
SickKids Foundation
2016-2022
Presbyterian Hospital
2016-2022
Background Ethiopia is one of the countries with highest burden neglected tropical diseases (NTDs), 16 20 recognised NTDs considered a public health problem, twelve which have been identified as priorities by Ethiopian Federal Ministry Health. However, until recently not received adequate attention at national and subnational levels in country. This study assessed feasibility, acceptability, cost-effectiveness an NTD intervention when integrated into primary care system Ethiopia. Methods was...
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized heterogeneity observed MBs with sonic hedgehog (SHH) activation could be due differences developmental pathways. To investigate this question, here perform single-nucleus RNA sequencing on highly differentiated SHH extensively nodular histology malignant cells resembling each stage of canonical...
Healthcare workers (HCWs) are at the frontline of Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity literature on their knowledge, attitudes and practices (KAP) in relation to pandemic. Community Health Workers (CHWs) Mozambique known locally as agentes polivalentes elementares (APEs). While technical guidance surrounding COVID-19 available support APEs, communicating this information has been challenging due restrictions travel, face-to-face group meetings...
Summary: We are building the world's first Virtual Child–a computer model of normal and cancerous human development at level each individual cell. The Child will “develop cancer” that we subject to unlimited virtual clinical trials pinpoint, predict, prioritize potential new treatments, bringing forward day when no child dies cancer, giving one opportunity lead a full healthy life.
The cancer stem cell (CSC) marker CD133 is widely expressed in gliomas and employed mostly by use of the CD133/1 antibody which binds extracellular glycosylated AC133 epitope. recognition may, however, be affected its glycosylation pattern oxygen tension. present study investigates effect deprivation on expression status employing a high AC133-expressing glioblastoma multiforme (GBM) line, IN699. IN699 cells were cultured under normoxic (21% O2) hypoxic (3% conditions. was analysed western...
Seasonal malaria chemoprevention (SMC) involves administering antimalarial drugs at monthly intervals during the high transmission period to children aged 3 59 months as recommended by World Health Organization. Typically, a full SMC course is administered over four cycles from July October, coinciding with rainy season. However, an analysis of rainfall patterns suggest that season longer and starting early June in south Burkina Faso, leading rise cases prior first cycle. This study assessed...
Abstract Background Malaria remains a major global health problem often worsened by political instability and armed conflict. The purpose of the study was to explore community knowledge, attitudes practices on malaria prevention, understand burden health-seeking behaviours caregivers children under-five in conflict-affected communities South West Littoral Regions Cameroon. Methods A cross-sectional survey involving internally displaced persons (IDPS), host population, their conducted across...
Abstract Background Quality data from Health Management Information Systems (HMIS) are important for tracking the effectiveness of malaria control interventions. However, HMIS in many resource-limited settings do not currently meet standards set by World Organization (WHO). We aimed to assess quality and associated factors Chad. Methods A cross-sectional study was conducted 14 health facilities Massaguet district. Data on children under 15 years were obtained external patient register...
<h3>ABSTRACT</h3> <h3>Background:</h3> To prevent malaria among children aged 3–59 months in areas with high seasonal transmission, chemoprevention (SMC) is recommended. In Chad, there evidence of SMC administration to older than 5 years (referred as "leakage"). This study aimed understand the reasons for leakage and explore feasibility acceptability extending delivery 5–10 Chad. <h3>Methods:</h3> We conducted a mixed-methods Massaguet health district cross-sectional survey determine...
Few studies on the biologic and molecular properties of pediatric glioblastoma have been performed. Until now, differential genomic analysis CD133+ve CD133-ve fractions has not described in glioma. We hypothesize only that presence CD133 could be source tumor resistance but also maintenance this molecule by hypoxia dictates cellular behavior. From a series human biopsies investigated, one, IN699 (from glioblastoma), generated greater than 4% total cell volume as cells. Using glioblastoma,...
Abstract Chimeric Antigen receptor T cell (CAR-T) treatments for solid cancers have been compromised by limited expansion and survival in the tumor microenvironment following interaction with antigen-expressing target cells. Using B7H3 as a model antigen broad clinical applicability, we evaluated relationship between antibody/antigen affinity of three candidate binders functional characteristics: avidity, prolonged cytotoxicity tumoroid re-stimulation assays, vivo anti-tumoral responses....