A5008159406- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Hemoglobinopathies and Related Disorders
- COVID-19 epidemiological studies
- Neonatal Health and Biochemistry
- Parasites and Host Interactions
- Child Nutrition and Water Access
- HIV, Drug Use, Sexual Risk
- Methemoglobinemia and Tumor Lysis Syndrome
- Travel-related health issues
- Blood donation and transfusion practices
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Cambodian History and Society
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
- Data-Driven Disease Surveillance
- Community Health and Development
- Insect Pest Control Strategies
- Bioactive Compounds and Antitumor Agents
- Hepatitis Viruses Studies and Epidemiology
- Biomedical Research and Pathophysiology
National Directorate of Geology
2025
Malaria Consortium
2017-2024
Cambodia National Malaria Center
2014-2022
University of South Florida
2020
London School of Hygiene & Tropical Medicine
2005-2019
University of London
2010-2019
Mahidol Oxford Tropical Medicine Research Unit
2016
Mahidol University
2016
Liverpool School of Tropical Medicine
2011-2016
University of Liverpool
2011-2015
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Seasonal malaria chemoprevention, previously known as intermittent preventive treatment in children, is highly effective areas with a short transmission season. Here we assess seasonality incidence data and define predictor of based on rainfall. We then use spatial rainfall, endemicity population to identify likely have seasonal incidence, estimate the at risk burden where chemoprevention would be appropriate. that suitable for there are 39 million children under 5 years age, who experience...
The relationships between human population movement (HPM) and health are a concern at global level. In the case of malaria, those links crucial in relation to spread drug resistant parasites elimination malaria Greater Mekong sub-Region (GMS) beyond. mobile migrant populations (MMP) who involved forest related activities both high risk being infected with receiving late sub-standard treatment due poor access services. Cambodia, 2012, National Malaria Control Programme (NMCP) identified, as...
A greater understanding of the relationship between transmission intensity, seasonality and age-pattern malaria is needed to guide appropriate targeting interventions in different epidemiological settings. systematic literature review identified studies which reported age paediatric hospital admissions with cerebral (CM), severe malarial anaemia (SMA), or respiratory distress (RD). Study sites were categorized into a 3 × 2 matrix Plasmodium falciparum intensity seasonality. Probability...
In some areas of Africa, health facility data have indicated declines in malaria that might resulted from increasingly effective control programs. Most such reports been countries where transmission is highly seasonal or modest intensity. Malawi, perennial intense, and measures scaled up during the past decade. We examined for children seen as outpatients parasitemia-positive hospitalized with cerebral a large national hospital. The proportion Plasmodium falciparum-positive slides among...
As momentum towards malaria elimination grows, strategies are being developed for scale-up in settings. One prominent strategy, reactive case detection (RACD), involves screening and treating individuals living close proximity to passively detected, or "index" cases. This study aims use RACD quantify Plasmodium parasitaemia households of index cases, identify risk factors infection; these data could inform approaches target groups. was conducted the Western Cambodian province Pailin between...
Introduction Nontyphoidal Salmonellae (NTS) are responsible for a huge burden of bloodstream infection in Sub-Saharan African children. Recent reports decline invasive NTS (iNTS) disease from Kenya and The Gambia have emphasised an association with malaria control. Following similar iNTS Malawi, we used 9 years continuous longitudinal data to model the interrelationships between disease, malaria, HIV malnutrition. Methods Trends monthly numbers childhood presenting at Queen's Hospital,...
Background User-friendly, accurate, point-of-care rapid tests to detect glucose-6-phosphate dehydrogenase deficiency (G6PDd) are urgently needed at peripheral level safely recommend primaquine for malaria elimination. Methods The CareStart G6PD RDT (AccessBio, New Jersey, USA), a novel diagnostic test and the most commonly used test, fluorescent spot (FST) were assessed against quantitatively measured enzyme activity detecting G6PDd. Subjects healthy males non-pregnant females aged 18 years...
Healthcare workers (HCWs) are at the frontline of Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity literature on their knowledge, attitudes and practices (KAP) in relation to pandemic. Community Health Workers (CHWs) Mozambique known locally as agentes polivalentes elementares (APEs). While technical guidance surrounding COVID-19 available support APEs, communicating this information has been challenging due restrictions travel, face-to-face group meetings...
Background In 2012, the WHO issued a policy recommendation for use of seasonal malaria chemoprevention (SMC) to children 3–59 months in areas highly transmission. Clinical trials have found SMC prevent around 75% clinical malaria. Impact under routine programmatic conditions has been assessed during research studies but there is need identify sustainable methods monitor impact using routinely collected data. Methods Data from Demographic Health Surveys were merged with rainfall, geographical...
Background Human population movement across country borders presents a real challenge for malaria control and elimination efforts in Cambodia its neighbouring countries. To quantify Plasmodium infection among the border-crossing population, including asymptomatic artemisinin resistant (AR) parasites, three official border crossing points, one from each of Cambodia's with Thailand, Laos Vietnam, were selected sampling. Methods Findings A total 3206 participants (of 4110 approached) recruited...
Abstract Background Seasonal malaria chemoprevention (SMC) is a highly effective intervention for prevention in high burden areas with seasonal transmission, historically implemented the Sahel. Mozambique contributes to 4% of global cases. Malaria Consortium, partnership National Control Programme, conducted two-year phased SMC study Nampula province using sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), or SPAQ, children under five. Phase one results presented here highlight...
Aggregate malaria data reporting accuracy indicates the overall quality of reported surveillance and is calculated using a routine audit (RDQA) toolkit during health facility audit. Three example scenarios are presented that highlight limitations aggregate methods three RDQA toolkits. A weighted absolute percentage error-based (WADRA) approach was found to resolve these by register values as weighting factor, enabling detection low-accuracy facilities otherwise considered high-accuracy...
There is currently no standard way of defining malaria seasonality, resulting in a wide range definitions reported the literature. Malaria cases show seasonal peaks most endemic settings, and choice timing for optimal control may vary by seasonality. A simple approach presented to describe seasonality malaria, aid localized policymaking targeting interventions. series systematic literature reviews were undertaken identify studies reporting on monthly data full calendar years clinical...
Households in malaria endemic countries experience considerable costs accessing formal health facilities because of childhood malaria. The Ministry Health Malawi has defined certain villages as hard-to-reach on the basis either their distance from or inaccessibility. Some these have been assigned a community worker, responsible for referring febrile children to facility. facility utilization and household attending were compared between individuals living near district hospital those...
Novel malaria monitoring and evaluation (M&E) tools are urgently needed to complement the current "gold standard" Malaria Indicator Surveys (MIS). Rapid up scaling of control efforts is resulting in substantial reductions burden across sub-Saharan Africa. As transmission goes down, timely, accurate, sub-national, district level estimates guide increasingly targeted remaining hotspot areas. To test a novel M&E tool, we have conducted continuous ("rolling") MIS (rMIS) since May 2010 covering...
Abstract Background Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be address transmission of malaria, particularly among mobile migrant populations night-time workers such as rubber tappers, who may beyond the reach core interventions. However, more information required on acceptability preferences...
Positive deviance (PD) is an asset-based, community-driven approach to behaviour change that has successfully been applied address many health and social problems. It yet have assessed for malaria control but may represent a promising tool elimination given its suitability in targeting small remote population groups, apparent sustainability ability instil high amount of community mobilisation. Here, the PD methodology as explained, with focus upon qualitative assessment proof concept study...
Accurate malaria stratification is essential for effective targeting of interventions but represents a particular challenge in pre-elimination settings. In these settings transmission typically sufficiently low and spatially heterogeneous to warrant need estimates risk at sub-district or village level also likely be high render the type decision support systems appropriate final stages elimination impractical. such scenario it arguably more feasible strengthen existing passive surveillance...