A5101983925- RNA modifications and cancer
- Dermatology and Skin Diseases
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Autoimmune Bullous Skin Diseases
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Nail Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis B Virus Studies
- Renal and related cancers
- Virus-based gene therapy research
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Genetic factors in colorectal cancer
- Contact Dermatitis and Allergies
- Cancer-related Molecular Pathways
- Genital Health and Disease
- Polyomavirus and related diseases
- Cancer Diagnosis and Treatment
First Hospital of China Medical University
2017-2025
China Medical University
2013-2025
Fifth Affiliated Hospital of Zhengzhou University
2013-2025
Nigeria Centre for Disease Control
2023
Ministry of Education of the People's Republic of China
2022
University of Portsmouth
2013-2021
Centers for Disease Control and Prevention
2010-2021
Creative Commons
2019-2020
National Center for Immunization and Respiratory Diseases
2020
Fundación Juan March
2019
Abstract 5-Fluorouracil (FU) has been widely used for more than four decades in the treatment of a range common cancers. The fluorine-substituted uracila analogue is converted to several active metabolites but mechanism cytotoxicity remained unclear. In cited unsubstantiated model, FU thought kill cells via inhibition thymidylate synthase and increased use dUTP place TTP during DNA replication, with subsequent excision high levels uracil causing fragmentation newly synthesized DNA. Using...
HIV incidence was substantially lower among circumcised versus uncircumcised heterosexual African men in three clinical trials. Based on those findings, we modeled the potential effect of newborn male circumcision a U.S. male's lifetime risk HIV, including associated costs and quality-adjusted life-years saved.Given published estimates males' risk, calculated fraction attributable to behavior from 2005-2006 surveillance data. We assumed 60% efficacy reducing heterosexually-acquired over...
Atopic dermatitis (AD) is a common inflammatory skin disorder that affects both children and adults, characterized by pruritus scaly, dry eczematous lesions. This study aimed to gather knowledge on the actual use effectiveness of Pimecrolimus (PIM) in Chinese patients with mild-to-moderate AD affecting sensitive areas routine clinical practice. multicentre non-interventional included 130 subjects from China, divided into two age groups (2-12 years ≥12 years). The primary endpoint was change...
The cancer stem cell (CSC) marker CD133 is widely expressed in gliomas and employed mostly by use of the CD133/1 antibody which binds extracellular glycosylated AC133 epitope. recognition may, however, be affected its glycosylation pattern oxygen tension. present study investigates effect deprivation on expression status employing a high AC133-expressing glioblastoma multiforme (GBM) line, IN699. IN699 cells were cultured under normoxic (21% O2) hypoxic (3% conditions. was analysed western...
Promoter hypermethylation of the p16INK4a gene was investigated in 111 cases tumor tissue, as well 136 circulating plasma and 95 sputum samples from Chinese patients with primary lung cancer, using a modified protocol semi-nested methylation-specific-PCR (MSP). The results showed hypermethylated p16 sequence 80.2% tissues frequencies 75.7 74.7% specimens, respectively. Among patients, 50 matched plasma, tissue same individual were analyzed. Of these, promoter detected 84.0% tissues, 72.0...
Seborrheic dermatitis (SD) is a common inflammatory skin condition. The etiology unclear, although overgrowth of Malassezia on the has been suggested to cause SD. This study investigated whether colonization with Staphylococcus plays role in facial SD, which was not well addressed previously.The conducted from September 1, 2011 February 20, 2012 First Hospital China Medical University. In first phase, evaluated level transepidermal water loss (TEWL) and number colony-forming units (CFU)...
Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how DNA (mtDNA) mutations contribute GBM biology and therapeutic remains poorly described. We sought determine spectrum of functional complex III IV mtDNA GBM. The complete genomes 10 lines were obtained using next-generation sequencing...
Lysine succinylation is a newly identified posttranslational modification (PTM), which exists widely from prokaryotes to eukaryotes and participates in various cellular processes, especially the metabolic processes. Staphylococcus epidermidis commensal bacterium skin, attracts more attention as pathogen, immunocompromised patients neonates by attaching medical devices forming biofilms. However, significance of lysine S. proteins has not been investigated. The purpose this study was...
The overexpression of inflammasome components is correlated with diabetes‑associated complications. Oleanolic acid a triterpenoid compound which important in arterial injury. present study evaluated whether oleanolic improved diabetic rat carotid artery injury through the inhibition nucleotide‑binding domain, leucine‑rich‑containing family, pyrin domain‑containing‑3 (NLRP3) inflammasomes signaling pathways. A model was induced using streptozotocin (60 mg/kg) and underwent Morphometric...
Microsatellite analysis of urine sediments has shown promise as a highly sensitive and specific technique for the detection bladder cancer. However, most studies have been conducted in Western countries with Caucasian subjects. We explored potential microsatellite detecting cancer Chinese people.We performed surgical specimens sediment cells collected from patients tumors. Those markers giving clearly readable patterns showing susceptibility to alterations were used panel detect primary A...
Abstract Suppression subtractive hybridization (SSH) was applied to identify differentially expressed genes in the SV40LT immortalized human bronchial epithelial cell line Y‐BE, with normal cells (HBEC) as a control. Two cDNA libraries of up‐ and downregulated were generated, comprising 218 known 131 unknown total. The expression 22 clones from 2 investigated by Northern blot analysis, 86.4% (19/22) them showed differential between Y‐BE HBEC. Although are nontumorigenic nude mice,...
Prostaglandin E1 (PGE1) is widely used in the treatment of limb ischemia for its potent vasodilatory and antiplatelet effects. In order to assess curative effect liposomal PGE1 (lipo-PGE1) as an adjuvant surgery patients with acute lower (ALLI), 204 who underwent hybrid procedures (operative thromboembolectomy or bypass necessary endovascular interventions) ALLI were randomly divided into a blank control group lipo-PGE1 (intravenous infusion 20 μg/day 12-14 consecutive days following...
dermatitis, and vitiligo do not retain gentian violet.Thus, in vivo Gram staining has potential to be a rapid diagnostic test, especially given the prevalence of tinea versicolor developing world, as well therapeutic agent.Further studies antifungal activity violet are indicated.
Zimbabwe introduced human papillomavirus (HPV) vaccine nationally in May 2018, targeting multiple cohorts (girls aged 10-14 years) through a school-based vaccination campaign. One year later, the second dose was administered to concurrently with first given new single cohort of girls grade 5. We conducted cross-sectional surveys among health workers, school personnel, and community members assess feasibility implementation, training, social mobilization, acceptability.Thirty districts were...
Background and Objectives In China, paid donation is prohibited by law. There little literature assessing donor motivation in comparison with western countries such as Canada important understanding the application of Western literature. We compared motivational factors donors from city Xi’an, Canadian matched for age, sex status. Materials Methods A total 218 Xi’an completed an interview about did Frequencies percentages responses to questions were tabulated using Chi‐squared test. Results...
Breast-to-brain metastasis (BBM) often represents a terminal event, due to the inability of many systemic treatments cross blood–brain barrier (BBB), rendering brain sanctuary site for tumour cells. Identifying genetic variations that can predict patients who will develop BBM would allow targeting adjuvant reduce risk while disease bulk is minimal. Germ-line may contribute whether forms by influencing primary subtype presents, or host response treatment regimen, facilitating transition cells...
Most plane warts are recalcitrant to treatment. Both cryotherapy and local hyperthermia have been applied treat warts. However, no direct comparative study on their respective efficacy safety has ever performed. To assess the of at 43 ± 1°C versus liquid nitrogen for Sequential patients with entered study, either receiving or therapy discretion recommendations consultants. Cryotherapy was delivered in two sessions 2 weeks apart, while three consecutive days, plus similar treatments 10 3 days...