A5101441319- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Science, Research, and Medicine
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Harbin Medical University
2016-2023
Peking Union Medical College Hospital
2006-2022
State Key Laboratory of Oncogene and Related Genes
2022
Shanghai Jiao Tong University
2018-2022
Academy of Medical Sciences
1997-2021
State Key Laboratory of Molecular Oncology
2021
Cancer Institute (WIA)
2015-2021
National Clinical Research
2021
Weatherford College
2021
// Rui Shi 1 , Pei-Yin Wang 2 Xin-Yi Li 4 Jian-Xin Chen Yan Xin-Zhong Zhang Chen-Guang 3, 6 Tao Jiang 5 Wen-Bin 1, * Wei Ding Shu-Jun Cheng Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Neurosurgery, The First Affiliated Hospital Xinxiang Henan, 3 Key Laboratory for Tumor Invasion and Metastasis, Cancer Institute University South Florida, Tampa, FL, USA Tiantan Biochemistry, Molecular Biology These authors have contributed equally to this work...
Telomerase reverse transcriptase (<i>TERT</i>) promoter mutation has been reported to be associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study examined the status of <i>TERT</i> distant metastatic DTC and evaluated correlation between radioiodine uptake, as well that therapy response. <b>Methods:</b><i>TERT</i> B-Raf proto-oncogene (<i>BRAF</i>) V600E were retrospectively primary tumors 66 patients DTC. Stimulated thyroglobulin (sTg) changes, uptake...
The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell proliferation, ECM invasion, tumor progression, and metastasis. present study evaluated the clinical biological importance of human lung cancer.Tissue microarrays derived from non-small cancer (NSCLC) patients were analyzed immunohistochemically. Osteopontin protein expression was observed 64.5% (205 318) primary tumors 75.5% (108 143) lymph node metastases, but only...
The transmembrane and secreted protein delta-like 1 homolog (DLK1) belongs to the EGF-like family. It is widely accepted that DLK1 plays important roles in regulating cell differentiation, such as adipogenesis osteogenesis. Aberrant expression of has been found various types human cancers, including lung cancer. A previous study this lab revealed associated with tumor invasion, although mechanism still unknown. To explore potential effects might have on was overexpressed or knocked down...
Rationale: Ground-glass opacity (GGO)-associated lung cancers are common and radiologically distinct clinical entities known to have an indolent course superior survival, implying a unique underlying biology. However, the molecular immune characteristics of GGO-associated nodules not been systemically studied. Objectives: To provide mechanistic insights for treatment these entities. Methods: We initiated prospective cohort study collect characterize pulmonary with GGO components (nonsolid...
Abstract PURPOSE: Expression of targeting protein for Xklp2 (TPX2), a microtubule-associated protein, is tightly cell cycle regulated. Abnormally expressed TPX2 has been reported in various malignancies, but less known lung cancer. The present study appraised the significance aberrant expression tumorigenesis and progression human squamous carcinoma (SCC) lung. EXPERIMENTAL DESIGN AND RESULTS: expressive status was firstly examined with cancer (L, PAa, PG) immortalized bronchial epithelial...
The tumor environment is of vital importance for the incidence and development colorectal cancer. Increasing evidence in recent years has elaborate role cancer-subtype classification patients' prognosis, but a comprehensive understanding purely depending on stromal compartment lacking. To decipher features cancer explore its immune context composition classification, we performed gene expression microarray microdissection-processed compartments adjacent normal tissues. Through integrated...
Intratumoral heterogeneity has been revealed in primary liver carcinoma (PLC). However, spatial of tumor-infiltrating lymphocytes (TILs), which reflects one dimension a tumor's heterogeneity, and the relationship between TIL diversity, local immune response mutation burden remain unexplored PLC. Therefore, we performed repertoire sequencing, gene expression profiling analysis whole-exome sequencing parallel on five regions each tumor matched adjacent normal tissues peripheral blood from PLC...
Abstract Understanding the interactions between tumors and host immune system holds great promise to uncover biomarkers for targeted therapies, predict prognosis of patients guide clinical treatment. However, signatures glioblastoma multiforme (GBM) remain largely unstudied in terms systematic analyses. We aimed classify GBM samples according immune‐related genes complement existing immunotherapy knowledge. In this study, we designed a strategy identify 3 subtypes representing different...
Promoter hypermethylation of the p16INK4a gene was investigated in 111 cases tumor tissue, as well 136 circulating plasma and 95 sputum samples from Chinese patients with primary lung cancer, using a modified protocol semi-nested methylation-specific-PCR (MSP). The results showed hypermethylated p16 sequence 80.2% tissues frequencies 75.7 74.7% specimens, respectively. Among patients, 50 matched plasma, tissue same individual were analyzed. Of these, promoter detected 84.0% tissues, 72.0...
Hypothetically, intratumoral genomic heterogeneity has the potential to foster tumor-infiltrating lymphocyte (TIL) diversity; however, no study directly tested this hypothesis by simultaneously investigating somatic mutations, TIL diversity, and immune response activity. Thus, we performed whole-exome sequencing, repertoire sequencing gene expression on ten spatially separated tumor samples obtained from two masses excised a glioblastoma multiforme (GBM) patient, included peripheral blood as...
Although several researches have explored the similarity across development and tumorigenesis in cellular behavior underlying molecular mechanisms, not many investigated developmental characteristics at proteomic level further extended to cancer clinical outcome. In this study, we used iTRAQ quantify protein expression changes during macaque rhesus brain from fetuses gestation 70 days after born 5 years. Then, performed weighted gene co-expression network analysis (WGCNA) on data of identify...
// Shou-Bo Yang 1 , Kai-Di Gao 2 Tao Jiang 3 Shu-Jun Cheng and Wen-Bin Li Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Rehabilitation Hospital Neurosurgery, Tiantan Correspondence to: Li, email: liwenbin@ccmu.edu.cn Keywords: bevacizumab, chemotherapy, glioblastoma, meta-analysis, prognosis Received: October 24, 2016 Accepted: March 22, 2017 Published: April 07, 2017 ABSTRACT...
Abstract Alternative RNA splicing is one of the most important mechanisms posttranscriptional gene regulation, which contributes to protein diversity in eukaryotes. It well known that dysregulation a critical mechanism tumor pathogenesis and rationale for promising splice-switching therapeutics cancer treatment. Although we have comprehensive understanding DNA mutations, abnormal expression profiles, epigenomics, proteomics lung adenocarcinoma (LUAD), little about its aberrant alternative...