A5101473967- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Microfluidic and Capillary Electrophoresis Applications
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cell Image Analysis Techniques
- Advancements in Transdermal Drug Delivery
- Microfluidic and Bio-sensing Technologies
- Epigenetics and DNA Methylation
- AI in cancer detection
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Graphene and Nanomaterials Applications
- Cancer-related Molecular Pathways
- Esophageal Cancer Research and Treatment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lipid Membrane Structure and Behavior
- Advanced Proteomics Techniques and Applications
- Bone Tissue Engineering Materials
- Medical Imaging Techniques and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shenzhen University
2019-2024
National Cancer Center
2023
National Clinical Research
2019-2022
Liaocheng People's Hospital
2019-2021
Cancer Hospital of Chinese Academy of Medical Sciences
2019
Hunan University
2019
China Medical University
2017-2018
National Synchrotron Radiation Laboratory
2010
University of Science and Technology of China
2010
Dissolvable polymeric microneedles (DPMNs) are promising transdermal drug delivery systems with minimal invasiveness and improved patient compliance. Incorporation of a small amount graphene oxide (GO) in the biocompatible polymers for microneedle fabrication results important new DPMN properties, that is, dramatically enhanced mechanic strength (10–17 times at 500 mg/mL GO), moisture resistance, self-sterilization, antibacterial anti-inflammatory properties (demonstrated vitro),...
Multimodal nanotherapeutic cancer treatments are widely studied but often limited by their costly and complex syntheses that not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through synergistic combination glucose starvation, photothermal therapy, advanced chemodynamic therapy enabled near-infrared irradiation coupled with Fenton-like reactions were enhanced endogenous chloride.
The objective of this study was to assess the prognostic value metabolic tumor burden measured by positron emission tomography/computed tomography (PET/CT) in patients with stage I lung adenocarcinoma.We reviewed 127 consecutive pathologically proven adenocarcinoma who underwent pretreatment [18F]FDG PET/CT scans our hospital from 2005 June 2012 June. maximum, mean, and peak standardized uptake (SUVmax, SUVmean, SUVpeak), volume (MTV), total lesion glycolysis (TLG), computed (CTV) were...
Lung cancer is a highly heterogeneous malignancy, and despite the rapid development of chemotherapy radiotherapy, acquired drug resistance tumor progression still occur. Thus, it urgent to identify novel therapeutic targets. Our research aims screen biomarkers associated with prognosis lung carcinoma patients explore potential regulatory mechanisms. We obtained RNA sequencing (RNA-seq) data from public databases. Clinical signature analysis, weighted gene coexpression network analysis...
Abstract T cells and cell receptors (TCRs) play pivotal roles in adaptive immune responses against tumors. The development of next-generation sequencing technologies has enabled the analysis TCRβ repertoire usage. Given scarce investigations on TCR lung cancer tissues, this study, we analyzed repertoires tissues matched distant non-tumor (normal tissues) from 15 patients. Based our results, general distribution clones was similar between normal tissues; however, proportion highly expanded...
Polymeric microneedles (PMNs) are an attractive transdermal drug delivery approach with minimal invasiveness and improved patient compliance. However, it is uncomfortable inconvenient for patients to wear a PMN patch hours or days until complete payload release. Here, we report facile strategy fabricate rapidly separable arrays activated by near-infrared (NIR) light (NIR-RS-PMN) enhanced mechanical strength through introduction of photothermal-sensitive spacer integrating plasmonic gold...
The aim of the study was to investigate suitable segmentation method in small, low uptake and heterogeneous nodules stage I lung adenocarcinoma.133 adenocarcinoma patients with 18 F-FDG PET/CT scans were enrolled this retrospective study.All lesions divided into different groups according nodule density, size, maximum standard value (SUV max ) level.Four PET methods performed, including percentage threshold SUV (T42% T42% Â RC), gradientbased (adaptive iterative algorithm, AT-AIA),...
Objective: To investigate the epidemiological characteristics and current status of surgical management for esophageal cancer in China. Methods: A national database was setup through a network platform. The clinical data treated by surgery collected from 70 major hospitals China between January 2009 December 2014. Results: Complete 8 181 cases patients who underwent were recorded recruited analysis. Among them, 6 052 male 2 129 female, average age 60.5 years.The investigation results showed...
Cellular structures of the fission yeast, Schizosaccharomyces pombe, were examined by using hard X-ray tomography. Since cells are nearly transparent to X-rays, Zernike phase contrast and heavy metal staining introduced improve image contrast. Through such methods, images taken at 8 keV displayed sufficient for observing cellular structures. The cell wall, intracellular organelles entire structural organization whole visualized in three-dimensional a resolution better than 100 nm. Comparison...
Previous studies have demonstrated that survival of patients with non-small cell lung cancer (NSCLC) oligometastasis may benefit from local treatment. The purpose this study was to compare the efficacy surgical treatment systematic chemoradiotherapy in NSCLC oligometastasis.Data a total 172 were collected at our Cancer Hospital January 2006 December 2016. divided into two groups: group A (82 cases) underwent primary and adjuvant chemotherapy performed after operation, while B (90 received...
The aim of this study was to evaluate the significance spread through air spaces (STAS) in early lung adenocarcinomas after radical lobectomy and lymphadenectomy.A total 242 patients with less than 4 cm (8th pStage I) were selected from cancer surgically treated January, 2009 September, 2011. Pathological review focused on STAS as well histological subtypes, blood vessel & neural invasion, pathological tumor size etc. Recurrence or disease-free survival (DFS) overall (OS) compared between...
Background With its growing popularity and potential outcome, preoperative three-dimensional reconstruction of chest computed tomography (CT) has been widely used in video-assisted thoracic surgery (VATS) segmentectomy for treating non-small cell lung cancer (NSCLC). This study aimed to summarize the experience anatomical variation analysis left upper pulmonary blood vessels bronchi based on CT. Materials methods A total 103 patients with early-stage NSCLC were chosen undergo VATS CT our...
Enhancer of zeste homologue 2 (EZH2), a catalytic subunit polycomb repressive complex 2, is overexpressed in number different tumors including breast cancer, and serves important roles cell cycle regulation, proliferation, apoptosis, tumorigenesis drug resistance. However, it remains unclear whether EZH2 contributes to tamoxifen resistance cancer. In the present study, role MCF‑7 cells was investigated. tamoxifen‑resistant (MCF‑7 TamR) cells. overexpression decreased sensitivity tamoxifen,...
Background: Patients with pathological stage I (p I) lung adenocarcinoma show variabilities in prognosis even after complete resection. The factors resulting heterogeneities of remain controversy. aim this study was to identify the risk affecting recurrence/metastasis and survival patients curatively resected p adenocarcinoma. Methods: A total 252 underwent curative resection between January 1st, 2009 September 30th, 2011 were retrospectively reviewed analyze associations recurrence...
Abstract Prediction of disease prognosis is essential for improving cancer patient care. Previously, we have demonstrated the feasibility using quantitative morphological features tumor pathology images to predict lung patients in a single cohort. In this study, developed and validated image-based predictive model adenocarcinoma (ADC) across multiple independent cohorts. Using image analysis, extracted from H&E stained sections formalin fixed paraffin embedded (FFPE) tissues. A...
Lung squamous cell carcinoma (LUSC) is one of the leading causes tumor-driven deaths in world. To date, studies on tumor heterogeneity LUSC at genomic level have only revealed limited therapeutic benefits. Therefore, system-wide research proteomic may further improve precision medicine strategies individual demands. this end, we performed and phosphoproteomic study for samples 25 Chinese patients. From our results, two subgroups (Cluster I II) based data were identified, which associated...
To screen and identify microRNAs (miRNAs) associated with the prognosis of lung adenocarcinoma (LUAD) using clinical samples construct a prediction model for LUAD.160 patient were used to miRNAs LUAD. Differentially expressed analyzed gene chip technology. The selected validated from validation sample group. Cox proportional hazards regression was Kaplan-Meier plot survival curves. Model power assessed by testing constructed real-time polymerase chain reaction (RT-PCR) data.The data showed...
Cell cycle activator E2F transcription factor 2 (E2F2) play a key role in tumor development and metastasis. Previous RNA sequence analysis (GSE134835) revealed E2F2 was significantly reduced by Zinc-finger protein 750 (ZNF750) oral squamous cell carcinoma (OSCC). This study aimed to determine the involvement of antitumor action ZNF750. The nude mouse xenograft model established subcutaneously injection stable line CAL-27oeZNF750 or CAL-27shZNF750. Xenograft volume weight measured. expression...