A5102829260- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Protein Structure and Dynamics
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Esophageal Cancer Research and Treatment
- Lipid Membrane Structure and Behavior
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Glycosylation and Glycoproteins Research
- Mechanisms of cancer metastasis
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
Tianjin Medical University
2013-2024
Beijing Proteome Research Center
2021
Tianjin People's Hospital
2015-2020
Tianjin Hospital
2013-2020
University of Nebraska Medical Center
2011
National Institutes of Health
2000
National Heart Lung and Blood Institute
2000
Simon Fraser University
1996-1997
Baylor College of Medicine
1996-1997
Background The aim of this study was to explore the potential mechanism circular RNA (circRNA) CirCHIPK3 on malignant proliferation and metastasis breast cancer (BC). Methods Human BC samples their matched normal adjacent tissues were obtained from 50 patients assess expression its relationship with prognosis. A series in vitro vivo functional experiments carried out elucidate role progression underlying molecular mechanisms. Moreover, interaction CirCHIPK3, miR‐193a, HMGB1 examined using...
Importance Apolipoprotein E polymorphism ε4 ( APOE ε4) and methylenetetrahydrofolate reductase MTHFR ) TT genotype are genetic risk factors of mild cognitive impairment (MCI), but whether this can be changed by modifiable lifestyle is unknown. Objective To explore unhealthy (unhealthy dietary intake, current smoking, nonlimited alcohol consumption, irregular physical activities) associated with a higher age-related MCI considering risk. Design, Setting, Participants This population-based...
Anti-silencing function 1B histone chaperone (ASF1B) is known to be an important modulator of oncogenic processes, yet its role in lung adenocarcinoma (LUAD) remains defined. In this study, integrated assessment The Cancer Genome Atlas (TCGA) and genotype-tissue expression (GTEx) datasets revealed the overexpression ASF1B all analyzed cancer types other than LAML. Genetic, epigenetic, microsatellite instability (MSI), tumor mutational burden (TMB) analysis showed that was regulated by single...
Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) mitochondrial DNA copy number (mtDNAcn) mediate relationship between MCI risk. The purpose present study is to evaluate whether inflammatory potential diet assessed by dietary index (DII), inflammation, LTL, mtDNAcn were associated with risk MCI.A population-based cohort was conducted total 2944 participants. During median...
Abstract Background TP53 mutations are common in non-small cell lung cancer (NSCLC), but no targeted therapies for these approved. Immunotherapy is the standard treatment NSCLC with negative driver mutations. Understanding how mutation status influences immunotherapy efficacy and tumor immune microenvironment (TIME) essential. Methods This study included 6, 148 Chinese patients who underwent next-generation sequencing (NGS); 158 also received multiplex immunohistochemistry (mIHC) to assess...
Withaferin A (WA) is a well-known steroidal lactone of the medicinally important plant, Withania somnifera. This secondary metabolite has been noted for its anticancer effects against number human cancer cell lines. However, there are limited studies investigating growth inhibitory potential WA osteosarcoma cells and underlying molecular mechanisms. Thus, in present study, antiproliferative activities WA, along with mechanisms action, were investigated using flow cytometry cycle distribution...
Minimal data are available on the prevalence of mild cognitive impairment (MCI) in older Chinese adults. Moreover, current information MCI shows important geographical variations.We aimed to assess and risk factors for by age sex among adults a North population.In this population-based cross-sectional study, we enrolled random sample 4,943 aged ≥ 60 years between March 2018 June 2019 Tianjin, China. Of these, 312 individuals were excluded due lack (e.g., fasting blood test). As result, 4,631...
The solution structure of the complex between cytoplasmic A domain (IIA(Mtl)) mannitol transporter II(Mannitol) and histidine-containing phosphocarrier protein (HPr) Escherichia coli phosphotransferase system has been solved by NMR, including use conjoined rigid body/torsion angle dynamics, residual dipolar couplings, coupled with cross-validation, to permit accurate orientation two proteins. convex surface on HPr, formed helices 1 2, interacts a complementary concave depression IIA(Mtl)...
Breast cancer is the most common in women worldwide, and incidence mortality rates are increasing every year. Dysregulation of microRNAs (miRNAs or miRs) an important step initiation development breast cancer. Previous studies demonstrated that miR-205-5p closely associated with occurrence cancer; however, underlying mechanisms remain unclear. In present study, reverse transcription-quantitative polymerase chain reaction assays were used to analyze miR-195-5p endoplasmic reticulum protein 29...
Aim: Acute Lung Injury (ALI) is an acute hypoxic respiratory insufficiency caused by various traumatic factors, manifested as progressive hypoxemia and distress, lung imaging shows a heterogeneous osmotic outbreak. Isorhamnetin (ISO) flavonoid compound isolated purified from medicinal plants, such Hippophae rhamnoides L. Ginkgo, has multiple pharmacological functions, anti-tumor, anti-myocardial hypoxia, cardiovascular protection. Our previous study shown that ISO could attenuate...
Structures of apoE(263−286) and apoE(267−289) have been determined in aqueous solution containing 90-fold molar excess perdeuterated sodium dodecyl sulfate by CD 1H NMR. Conformations were calculated distance geometry based on 370 276 NOE restraints, respectively. RMSD for superimposing the region 265−284 from an ensemble 41 structures is 0.64 ± 0.17 Å backbone atoms (N, Cα, CO) 1.51 0.13 all atoms. The 37 0.74 0.21 268−275 0.34 0.10 276−286. A two-domain structure was found with C-terminal...
The conformation of a synthetic peptide 46 residues from apoA-I was investigated by fluorescence, CD, and 2D NMR spectroscopies in lipid-mimetic environments. ApoA-I(142−187) is mainly unstructured water but helical SDS or dodecylphosphocholine (DPC), although the only associates with DPC at approximately critical micellar concentration. Solution structures apoA-I(142−187) were determined distance geometry calculations based on 450 (in DPC-d38) 397 SDS-d25) NOE-derived restraints,...
Breast cancer remains the most commonly diagnosed in Chinese women. Paclitaxel (PTX) is a chemotherapy medication used to treat breast patients. However, side effect of paclitaxel severe drug resistance. Previous studies demonstrated that dysregulation microRNAs could regulate sensitivity cancer. Here, present study aimed lucubrate underlying mechanisms miR-107 regulating cells PTX. The results was down-regulated tumor tissues, while TPD52 significantly up-regulated compared with non-tumor...
<b><i>Background:</i></b> Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) Alzheimer’s disease (AD) role folate homocysteine (Hcy) in this remain unclear. <b><i>Objectives:</i></b> We aimed investigate association between risks MCI/AD, explore whether Hcy may play a association....
The nutrition state plays an important role in the progress of aging. Folate may play a protecting mitochondrial (mt) DNA by reducing oxidative stress. primary aim this study was to examine association damage with risk Alzheimer's disease (AD), and explore possible folate metabolites matched case-control study. Serum function peripheral blood cells were determined 82 AD cases healthy controls, individually age, gender, education. patients had lower serum levels higher homocysteine (Hcy)...
The longitudinal association between serum folate concentrations and the risk of cognitive impairment remains unclear in populations with low levels. We examined mild (MCI) older adults China, where mandatory fortification foods folic acid has not been implemented. further explored if homocysteine (Hcy) leukocyte telomere length (LTL) mediate MCI.We performed a analysis 3974 participants aged ≥60 years from Tianjin Elderly Nutrition Cognition (TENC) cohort study. associations level overall...
The bacterial phosphoenolpyruvate:sugar phosphotransferase system accomplishes both the transport and phosphorylation of sugars as well regulation some cellular processes. An important component this is histidine-containing phosphocarrier protein, HPr, which accepts a phosphoryl group from enzyme I, transfers to IIA proteins, an allosteric regulator glycogen phosphorylase. Because nature surface on HPr that interacts with multiplicity proteins <i>Escherichia coli</i> was previously...