A5042153011- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Aging, Elder Care, and Social Issues
- Folate and B Vitamins Research
- Ginkgo biloba and Cashew Applications
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Cholinesterase and Neurodegenerative Diseases
- Health disparities and outcomes
- Neurological Disorders and Treatments
- Sleep and related disorders
- Lipoproteins and Cardiovascular Health
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Intergenerational Family Dynamics and Caregiving
- Cardiac Imaging and Diagnostics
- GDF15 and Related Biomarkers
- Sleep and Wakefulness Research
- Long-Term Effects of COVID-19
- Endoplasmic Reticulum Stress and Disease
- Neurological diseases and metabolism
- Neurological Complications and Syndromes
- Global Health Care Issues
Tianjin Huanhu Hospital
2015-2025
Inner Mongolia University of Science and Technology
2025
Beijing Tian Tan Hospital
2019-2024
Capital Medical University
2019-2024
Beijing Anzhen Hospital
2022-2024
Tianjin Medical University
2020-2024
National Clinical Research Center for Digestive Diseases
2020-2024
Tianjin University
2024
University of Utah
2023
University of York
2023
Population ageing is rapidly becoming a global issue and will have major impact on health policies programmes. The World Health Organization's Study AGEing adult (SAGE) aims to address the gap in reliable data scientific knowledge low- middle-income countries. SAGE longitudinal study with nationally representative samples of persons aged 50+ years China, Ghana, India, Mexico, Russia South Africa, smaller sample adults 18–49 each country for comparisons. Instruments are compatible other large...
The socioeconomic costs of Alzheimer's disease (AD) in China and its impact on global economic burden remain uncertain.We collected data from 3098 patients with AD 81 representative centers across estimated for individual patient total 2015. Based this data, we re-estimated the worldwide AD.The annual cost per was US $19,144.36, were $167.74 billion are predicted to reach $507.49 2030 $1.89 trillion 2050. our results, estimates dementia $957.56 2015, will be $2.54 2030, $9.12 2050, much more...
To evaluate caregiver burden and factors that influence this among caregivers patients with Alzheimer's disease in China.Long-term care can reduce the quality of life for result both mental physical exhaustion. However, little is known about associated China.The study had a quantitative cross-sectional design.A total 309 their were included study. The patients' cognitive, psychological functional status caregivers' burden, sleep state evaluated. Descriptive analyses, single-factor regression...
Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) a critical coenzyme metabolism significantly reduced in brain blood samples of patients with disease (AD).To explore the measurement thiamine metabolites AD.Blood TDP, monophosphate, levels were detected using high performance liquid chromatography (HPLC). The study included exploration validation phases. In phase, 338 control subjects 43 AD utilized...
Caregivers of individuals with neurodegenerative diseases, including frontotemporal dementia (FTD), Lewy body (DLB), and Alzheimer's disease (AD), experience high levels psychological physical stress, likely due to behavioral symptoms (BPSD). This study is the first simultaneously evaluate effects BPSD on caregiver burden in these three types dementia.A total 214 patients, probable FTD (n = 82), DLB 22), AD 110), as well their primary caregivers, were assessed using inventories cognitive...
Aims and objectives The primary aim of this study was to examine the correlations between patient caregiver characteristics with burden, anxiety depression in Alzheimer's Disease. Secondary determine which behavioural psychological symptoms had greatest impact on Background Caregivers individuals Disease experience high levels both psychologically physically. Previous studies have examined separately. However, no paper has these three conditions simultaneously. Design A cross‐sectional...
Background: While the lockdown strategies taken by many countries effectively limited spread of COVID-19, those were thought to have a negative impact on older people. This study aimed investigate cognitive function and neuropsychiatric symptoms over 1-year follow-up period in patients with mild impairment (MCI), Alzheimer's disease (AD) dementia Lewy bodies (DLB). Methods: We enrolled consecutive MCI, probable AD or DLB who receiving outpatient memory care before COVID-19 pandemic...
Introduction: Numerous countries went into lockdown to contain the COVID-19 outbreak, which has impeded follow-up of chronic diseases, such as cognitive impairment (CI). Cognitive and neuropsychiatric changes during pandemic are neglected in China, is world's whistleblower. To investigate neuropsychologic CI, well proportions rapid decline (RCD) before provide clinical evidence for CI intervention a public health emergency. Methods: We performed descriptive retrospective study based on...
Abstract The nervous system is highly dependent on the supply of oxygen and nutrients, so when demand for exceeds its supply, hypoxia induced. hippocampus very important in system. It has ability to control human behavior, memory, emotion, on. Therefore, damaged by hypoxia, it may cause diseases such as Alzheimer’s disease, Parkinson’s stroke. Alternative splicing plays an regulatory role processes growth disease occurrence development. However, function hypoxia-induced alternative...
Abstract INTRODUCTION Blood–brain barrier (BBB) breakdown is essential in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), whereas the variability BBB permeability to water contrast agent less clear. METHODS We investigated simultaneously using a novel tracer kinetic model for dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) 42 AD patients, 22 DLB healthy controls. All participants underwent clinical, cognitive, MRI assessments. RESULTS patients exhibited...
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to progression disease. We observed significant reduction in level alpha-1-antitrypsin (A1AT), hepatocyte-derived secreted factor, both patients MASH mice fed fast-food diet (FFD). KC-mediated inflammation, most notably IL-1β, led transcriptional inhibition A1AT by HNF4α. In...
The association between the estrogen receptor (ER-alpha) gene and dementia was examined in 223 patients with Alzheimer's disease (AD), 66 vascular (VD), 17 alcohol-associated (ALD) 134 healthy elderly control subjects. PvuII XbaI restriction fragment length polymorphisms of ER-alpha were represented as Pp (PvuII) Xx (XbaI), capital letters signifying absence sites small presence sites. We found that frequency P allele X late-onset AD (LOAD) group (P 0.51, 0.30) significantly higher than...
<b><i>Background/Aims:</i></b> The aim of this article was to estimate the prevalence and determine sociodemographic risk factors for dementia, Alzheimer's disease (AD) vascular dementia (VaD) among individuals residing in rural northern China. <b><i>Methods:</i></b> Between 2011 2012, residents aged ≥60 years areas China were clinically assessed symptoms AD VaD. Diagnoses made using established criteria standard procedures....
To examine the association between blood cholesterol concentrations and Alzheimer's disease (AD) in Chinese elderly. A case-control study was implemented November 2011 2017. Elderly patients aged ≥ 55 years with (n = 117) without AD (control participants; n were recruited from Neurology Central Hospital of Tianjin, China. The associations parameters assessed using multiple binary logistic regression analyses adjusted for covariates. Higher serum total (TC) low-density lipoprotein (LDL-C)...
Background Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora characteristics of the brain-gut axis play roles pathogeneses two diseases, suggesting that there may be a close connection between two. Most studies on constipation patients focused population with α-synucleinopathies [Parkinson’s disease (PDD), Lewy bodies (DLB)]. Few reported prevalence all-cause mild cognitive impairment (MCI) populations. Objective To assess MCI subtypes to...
Purpose To investigate the epidemiological characteristics of constipation in people aged 65 years and older several regions China. Patients Methods A cross-sectional study based on a cluster sampling design was conducted four cities China: Tianjin, Xiamen, Cangzhou Harbin. total 5,222 cases (age ≥ years) were recruited, survey via centralized household questionnaires that included following: basic demographic such as sex, age, education, marital status, living status occupation; social...
Apolipoprotein E σ4 allele (ApoE σ4) is associated with Alzheimer’s disease (AD) in familial and sporadic cases, but the associations of ApoE vascular dementia (VD) and/or ischemic cerebrovascular (ICVD) are still controversial. To clarify polymorphism AD, VD ICVD Japanese, we examined samples 255 patients 87 VD, 123 ICVD, as compared 117 age-matched healthy control subjects (CTL). The frequency was significantly higher group (0.21), (0.15) well AD (0.26) than CTL (0.08). These findings...
Parkinson's disease (PD) is a common cause of dementia in the elderly. Dementia Alzheimer's (AD) and PD share biologic clinical features. The estrogen receptor (ER) gene one susceptibility genes for AD. In order to test hypothesis that overlap between AD may have genetic basis, we determined ER polymorphisms 13 patients with (PDD) (age +/- SD; 71.9 5.5 years), 71 without (PDND) (68.4 7.5 86 (76.8 8.0 years) 51 control subjects (CTL) (74.9 6.9 years). genotypes were classified as P or p...
<b><i>Background:</i></b> Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes <i>(PSEN1, PSEN2,</i> <i>APP)</i> have been identified patients with early-onset AD. <b><i>Methods:</i></b> We performed gene sequencing <i>PSEN1, <i>APP</i> 61 AD 35 FTD Chinese patients. Amyloid load using...
<b><i>Background/Aims:</i></b> The burden of dementia among women in China, especially from rural areas, has increased due to their longevity and lower education levels compared with that men. Thus, we aimed assess sex differences the prevalence cognitive impairment its relevant determinants residents North China. <b><i>Methods:</i></b> Adults aged 60 years older no (CIND) were recruited this study. Demographic characteristics, traditional risk...