A5014836003- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
- Global Public Health Policies and Epidemiology
- Adolescent Sexual and Reproductive Health
- Poverty, Education, and Child Welfare
- Global Health Care Issues
- Child Nutrition and Water Access
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Chronic Disease Management Strategies
- HIV-related health complications and treatments
- Healthcare Systems and Reforms
- Migration, Health and Trauma
- Primary Care and Health Outcomes
- COVID-19 epidemiological studies
- Child and Adolescent Health
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- Genetic Associations and Epidemiology
- Autopsy Techniques and Outcomes
- Food Security and Health in Diverse Populations
University of the Witwatersrand
2016-2025
Agincourt Health and Socio-Demographic Surveillance System
2016-2025
South African Medical Research Council
2014-2025
Umeå University
2016-2025
Indepth Network
2015-2024
National Health Laboratory Service
2017-2023
University of Nigeria
2022
Centre for Global Health Research
2014-2022
Africa Health Research Institute
2017-2022
Burnet Institute
2022
Population ageing is rapidly becoming a global issue and will have major impact on health policies programmes. The World Health Organization's Study AGEing adult (SAGE) aims to address the gap in reliable data scientific knowledge low- middle-income countries. SAGE longitudinal study with nationally representative samples of persons aged 50+ years China, Ghana, India, Mexico, Russia South Africa, smaller sample adults 18–49 each country for comparisons. Instruments are compatible other large...
Given the importance of Africa to studies human origins and disease susceptibility, detailed characterization African genetic diversity is needed. The Genome Variation Project provides a resource with which design, implement interpret genomic in sub-Saharan worldwide. represents dense genotypes from 1,481 individuals whole-genome sequences 320 across Africa. Using this resource, we find novel evidence complex, regionally distinct hunter-gatherer Eurasian admixture We identify new loci under...
The Agincourt health and socio-demographic surveillance system (HDSS), located in rural northeast South Africa close to the Mozambique border, was established 1992 support district systems development led by post-apartheid ministry of health. HDSS (90 000 people), based on an annual update resident status vital events, now supports multiple investigations into causes consequences complex health, population social transitions. Observational work includes cohorts focusing different stages...
Low- to middle-income countries are undergoing a health transition with non-communicable diseases contributing substantially disease burden, despite persistence of undernutrition and infectious diseases. This study aimed investigate the prevalence patterns stunting overweight/obesity, hence risk for metabolic disease, in group children adolescents rural South Africa. A cross-sectional growth survey was conducted involving 3511 1-20 years, selected through stratified random sampling from...
BackgroundCash transfers have been proposed as an intervention to reduce HIV-infection risk for young women in sub-Saharan Africa. However, scarce evidence is available about their effect on reducing HIV acquisition. We aimed assess the of a conditional cash transfer incidence among rural South Africa.MethodsWe did phase 3, randomised controlled trial (HPTN 068) Bushbuckridge subdistrict Mpumalanga province, included girls aged 13–20 years if they were enrolled school grades 8–11, not...
Background : Verbal autopsy (VA) is the only available approach for determining cause of many deaths, where routine certification not in place. Therefore, it important to use standards and methods VA that maximise efficiency, consistency comparability. The World Health Organization (WHO) has led development 2012 WHO instrument as a new standard, intended both research tool registration deaths. Objective A public-domain probabilistic model interpreting data, InterVA-4, described, which builds...
A greater knowledge of the burden HIV in rural areas Southern Africa is needed, especially among older adults. We conducted a cross-sectional biomarker survey South African Agincourt Health and Socio-demographic Surveillance site 2010-2011 estimated prevalence risk factors. Using an age-sex stratified random sample ages 15+, total 5037 (65.7%) possible 7662 individuals were located 4362 (86.6%) consented to testing. was high (19.4%) characterized by large gender gap (10.6% for men 23.9%...
Cohort Profile : Health and Ageing in Africa: A Longitudinal Study of an INDEPTH Community South Africa (HAALSI)
BackgroundAntimicrobial misuse is common in low-income and middle-income countries (LMICs), this practice a driver of antibiotic resistance. We compared community-based access use practices across communities LMICs to identify contextually specific targets for interventions improve practices.MethodsWe did quantitative qualitative assessments six Africa (Mozambique, Ghana, South Africa) Asia (Bangladesh, Vietnam, Thailand) over 2·5-year study period (July 1, 2016–Dec 31, 2018). community...
BackgroundBy August, 2021, South Africa had been affected by three waves of SARS-CoV-2; the second associated with beta variant and third delta variant. Data on SARS-CoV-2 burden, transmission, asymptomatic infections from are scarce. We aimed to evaluate burden transmission in one rural urban community Africa.MethodsWe conducted a prospective cohort study households Agincourt, Mpumalanga province (rural site) Klerksdorp, North West (urban July, 2020 2021. randomly selected for site health...
Population studies provide insights into the interplay between gut microbiome and geographical, lifestyle, genetic environmental factors. However, low- middle-income countries, in which approximately 84% of world's population lives1, are not equitably represented large-scale research2-4. Here we present AWI-Gen 2 Microbiome Project, a cross-sectional study sampling 1,801 women from Burkina Faso, Ghana, Kenya South Africa. By engaging with communities that range rural horticultural to...
Summary objective To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in Agincourt subdistrict rural South Africa. methods Verbal autopsies (VAs) were conducted on deaths recorded during annual demographic and health surveillance over 3‐year period (1992–95) population about 63 000 people. Trained fieldworkers elicited signs symptoms terminal illness from close caregiver, using comprehensive questionnaire written local language....
Aim: To examine the hypothesis that circular labour migrants who become seriously ill while living away from home return to their rural homes convalesce and possibly die. Methods: Drawing on longitudinal data collected by Agincourt health demographic surveillance system in northeastern South Africa between 1995 2004, discrete time event history analysis is used estimate likelihood of dying for residents, short-term returning migrants, long-term controlling sex, age, historical period....
Rationale for study: Vital registration is generally lacking in infrastructurally weak areas where health and development problems are most pressing. Health demographic surveillance a response to the lack of valid information base that can provide high-quality longitudinal data on population dynamics, health, social change inform policy practice. Design measurement procedures: Continuous monitoring an entire geographically defined involves multi-round, prospective community study, with...
Globally, ageing impacts all countries, with a majority of older persons residing in lower- and middle-income countries now into the future. An understanding health well-being these populations is important for policy planning; however, research on adult that informs predominantly comes from higher-income countries. A collaboration between WHO Study global AGEing (SAGE) International Network Demographic Evaluation Populations Their Health developing (INDEPTH), support US National Institute...
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic environmental factors that influence body composition, fat distribution CMD risk, with the aim provide insights towards effective treatment intervention strategies. It provides research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya South Africa. Following process involved...
Background: World population growth will be increasingly concentrated in the urban areas of developing world; however, some scholars caution against oversimplification African urbanization noting that there may ``counterurbanization'' and a prevailing pattern circular rural—urban migration. The aim paper is to examine ongoing transition South Africa post-apartheid period, consider health social policy implications migration patterns. Methods: Two data sets were analysed, namely national...