A5059139132- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- HIV-related health complications and treatments
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- Global Public Health Policies and Epidemiology
- HIV/AIDS Research and Interventions
- Physical Activity and Health
- HIV/AIDS Impact and Responses
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Food Security and Health in Diverse Populations
- Lipoproteins and Cardiovascular Health
- Health disparities and outcomes
- Health Policy Implementation Science
- Hemoglobinopathies and Related Disorders
- Global Health and Epidemiology
- Mobile Health and mHealth Applications
- Cardiovascular Health and Risk Factors
- Genetic and phenotypic traits in livestock
- Forensic and Genetic Research
- Sleep and related disorders
- Primary Care and Health Outcomes
- Folate and B Vitamins Research
University of Limpopo
2013-2025
Indepth Network
2015
RMIT University
2005
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic environmental factors that influence body composition, fat distribution CMD risk, with the aim provide insights towards effective treatment intervention strategies. It provides research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya South Africa. Following process involved...
Background The aim of the study was to determine prevalence and determinants chronic non-communicable disease (NCD) risk factors in a rural community Limpopo Province South Africa. Methods This survey conducted using WHO "STEPwise approach surveillance diseases" (STEPS) methodology. Participants were residents Dikgale HDSS site standardised international protocols used measure behavioural (smoking, alcohol consumption, fruit vegetable intake and, physical activity) characteristics (weight,...
BackgroundRapid epidemiological health transitions occurring in vulnerable populations Africa that have an existing burden of infectious and non-communicable diseases predict increased risk consequent prevalence kidney disease. However, few studies characterised the true damage associated factors Africans. We investigated markers for known rural urban settings sub-Saharan Africa.MethodsIn this cross-sectional population study (Africa Wits-International Network Demographic Evaluation...
Abstract South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the population in Africa. Despite clear linguistic and geographic diversity, genetic differences between these have not been systematically investigated. Based on genome-wide data over 5000 individuals, representing eight major SEB groups, we provide strong evidence for fine-scale structure that broadly aligns with distribution is also congruent phylogeny (separation Nguni, Sotho-Tswana Tsonga speakers). Although...
To determine the prevalence and associated risk factors of cardiovascular diseases in a rural adult black population from Limpopo Province South Africa.A cross-sectional study.A sample 1608 women 498 men aged 30 years above participated study. Sociodemographic data, anthropometric measures (body mass index, waist/hip ratio), blood pressure biochemical were measured. A global disease (CVD) profile was developed.There high tobacco use for (57%) (35.4%), with (28.1%) predominantly using...
Laboratory tests used in the diagnosis of iron status lack specificity defining deficiency anaemia (IDA) and inflammation (AI). The serum transferrin receptor (sTfR) may provide more information this regard. 561 pre-school children was determined classified using conventional measurements. value concentration sTfR, ratio sTfR (microg/ml) to LogSF (microg/l) (TfR-Index), Log SF (microg/l)--(LogTfR:Fer ratio), classification were by comparing their distributions across status. Although there...
The risk of cardiovascular diseases (CVD) in human immunodeficiency virus (HIV) infected people on antiretroviral therapy (ART) from some rural parts Africa is not well known. We assessed CVD factors, the estimated 5-year Data collection adverse effects anti-HIV drugs (DA.) score and 10-year Framingham persons with HIV infection ART a area South Africa. A cross-sectional study which data demographic, lifestyle, chronic disease were collected using World Health Organization Stepwise approach...
Background: African populations are characterised by diversity at many levels including: demographic history, genetic ancestry, language, wealth, socio-political landscape, culture and behaviour. Several of these have a profound impact on body fat mass. Obesity, key risk factor for cardiovascular metabolic diseases, in the wake epidemiological health transitions across continent, requires detailed analysis together with other major factors.Objective: To compare regional sex-specific mass...
Introduction The contribution of obesity phenotypes to dyslipidaemia in middle-aged adults from four sub-Saharan African (SSA) countries at different stages the epidemiological transition has not been reported. We characterized lipid levels and investigated their relation with growing burden SSA countries. Methods A cross-sectional study was conducted Burkina Faso, Ghana, Kenya South Africa. Participants were middle aged adults, 40–60 years old residing sites for past 10 years....
Preventive health care represents the future for delivery in South Africa to improve management of chronic diseases as this has been implemented some time several countries tackle increasing burden diseases. Individual person's is unique, they move and out acute phases, there need integrate constructs continuity maximize wellbeing. The aim study was determine perceptions perspectives patients' nurses regarding disease terms barriers, facilitators their experiences. To meet our we used...
Health & Demographic Surveillance System Profile : The Dikgale and System.
Accurate and timely information on the causes of child deaths is essential in guiding efforts to improve survival, by providing data from which health profiles can be constructed relevant policies formulated. The purpose this study was identify death children younger than 5 years-old a tertiary hospital South Africa.Death certificates Pietersburg/Mankweng complex, for period January 1, 2008 through December 31, 2010, were obtained all patients years retrospectively reviewed. Data collected...
The study was conducted in the Dikgale Health and Demographic Surveillance System (DHDSS) site where we have observed increasing obesity levels, particularly women, despite evidence of high physical activity (PA) a relatively low daily energy intake. This aimed to assess socio-demographic, behavioural biological determinants body mass index (BMI) adult residents permanently residing DHDSS. A cross-sectional which characteristics from 1143 participants (aged 40-60 years) were collected using...
Purpose: We investigated the distribution of objectively measured ambulation levels and association to adiposity in a convenience sample adolescent adult, rural black South Africans. Methods: analyzed 7-d pedometry data, collected over period nine consecutive days, 789 subjects (women, n = 516; men, 273). Adiposity measures included body mass index (BMI) waist circumference (WC). Obesity was defined as BMI ≥ 30 kg·m−2 or WC 102 cm for men 88 women. Results: The average age- BMI-adjusted...
Mortality data are frequently presented at the overall population level, possibly obscuring small-scale variations over time and space between different sub-groups.Analysis of mortality from Dikgale Health Demographic Surveillance System, in rural South Africa, period 1996-2007, to identify local clustering among eight villages observed population.Mortality person-time observation were collected annually an open-cohort approximately 8,000 people 12 years. Poisson regression modelling...
Background Studies on the determinants of carotid intima-media thickness ( CIMT ), a marker sub-clinical atherosclerosis, mostly come from white, Asian, and diasporan black populations. We present data sub-Saharan Africa, which is experiencing rising burden cardiovascular diseases infectious diseases. Methods Results The H3 (Human Hereditary Health) in Africa's AWI-Gen (African-Wits-INDEPTH partnership for Genomic) study cross-sectional conducted adults aged 40 to 60 years Burkina Faso,...
after fortification, none of the women had low serum folate. Low red cell folate (<164 ng/ml) was observed in 26.4% subjects before and 1.9% fortification. The prevalence vitamin B12 deficiency (<145 pg/ml) 6.3% during phase 1 study increased to 11.3% 2. haemoglobin levels were present 7.5% 5% percentage with ferritin similar fortification (25%). Conclusion. shows a significant improvement status childbearing age approximately 9 months maize wheat foodstuffs South Africa, whereas no iron as...
Background: We describe the effect of 2 different accelerometer cut-points on physical activity (PA) patterns in rural and urban black South African women. Methods: Hip-mounted uni-axial accelerometers were worn for 6 to 7 days by (n = 272) 16) participants. Twenty-hour (4 AM 12 AM) PA counts (cts) volumes (min·day −1 ) extracted: sedentary (SED, <100 cts·min ), light (100–759 moderate-1 (MOD1, 760–1951 moderate-2 vigorous (MOD2VG, ≥1952 bouts ≥10 min ≥760 (MOD1VGbt) (MOD2VGbt). Results:...
Objective: The present study evaluated the prevalence of anaemia and its determinants in one- three-year-old children from Capricorn District Limpopo Province, South Africa. Methods: A prospective cohort conducted rural villages At birth, a 219 was followed until they were one three years age. Data collected included children’s anthropometric measurements, blood for biochemical analysis (full count, ferritin, folate vitamin B12) socio-demographic status.Results: year, (Hb < 11 g/dL) 52%...
Underweight in human immunodeficiency virus (HIV)-infected people on antiretroviral therapy (ART) complicates the management of HIV infection and contributes to mortality, whereas overweight increases risk cardiovascular disease (CVD).The study determined weight status associated factors with receiving ART.Rural primary health care clinics Dikgale, Limpopo province, South Africa.A cross-sectional which data were collected using World Health Organization (WHO) stepwise approach surveillance...
Objective. To assess whether the high prevalence of stunting and overweight accompanied by serum deficiencies iron, folate vitamin B12 in children at ages 1 3 years, can be explained their diet.Design. A prospective cohort study.Setting. Villages central region Limpopo province, which are serviced Mankweng Hospital.Subjects. (N = 219) followed from birth were included study. Of original cohort, 156 162 could traced assessed respectively. Dietary intake was using a quantitative food frequency...
Aims: Genetic variation at the apolipoprotein E (apoE) locus is an important determinant of plasma lipids. The aim present study was to evaluate association between genotype and lipid levels among a rural black population in South Africa. Methods: Lipid apoE genotypes were studied 505 volunteer subjects (363 women, 142 men) resident Dikgale demographic surveillance site. Results: Allele frequencies found be 0.190 for ε2, 0.518 ε3, 0.293 ε4, indicating relatively low frequency ε3 allele high...
The Dikgale Demographic Surveillance System (DDSS) site, established in 1995, is one of three rural surveillance sites South Africa. This paper describes detailed mortality patterns a African population the central region Limpopo Province.These data were based on yearly household visits to collect vital events, covering 63, 873 person-years observation over eight years.Crude was 7.5 per 1,000 (females: 6.9, males: 8.1). Under-1 year and under-5 years 15.1 5.8 person-years, respectively. Life...