A5031917269- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Obesity, Physical Activity, Diet
- Menstrual Health and Disorders
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cancer-related cognitive impairment studies
- Maternal Mental Health During Pregnancy and Postpartum
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Adipose Tissue and Metabolism
- Dementia and Cognitive Impairment Research
- Endometriosis Research and Treatment
- Body Composition Measurement Techniques
- Phytoestrogen effects and research
- Health, Environment, Cognitive Aging
- Pregnancy-related medical research
- Global Health Care Issues
- Physical Activity and Health
University College London
2025
University of the Witwatersrand
2014-2025
National Health Laboratory Service
2014-2025
Weatherford College
2023
South African Medical Research Council
2016
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic environmental factors that influence body composition, fat distribution CMD risk, with the aim provide insights towards effective treatment intervention strategies. It provides research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya South Africa. Following process involved...
There is a high and increasing prevalence of overweight obesity in South Africans all ages. Risk factors associated with must be identified to provide targets for intervention.To identify the demographic, socio-economic behavioural body mass index (BMI) middle-aged black African men women.Data on demographic were collected via questionnaire 1027 1008 women from Soweto Johannesburg, Africa. Weight height measured BMI was determined. Behavioural included tobacco use consumption alcohol,...
Background The aetiology of the metabolic syndrome and inter-relationship between risk factors for this are poorly understood. purpose investigation was to determine their interactions in a cohort women with high prevalence syndrome. Materials Methods Abdominal whole body composition (ultrasound dual-energy X-ray absorptiometry), blood pressure, cardiometabolic demographic were measured cross-sectional study 702 black African from Soweto, Johannesburg. Data analysed using multivariate...
Brain fog, referring to menopause-related subjective cognitive difficulties, is common in midlife women. Longitudinal studies find small but reliable declines objective memory performance as women transition into perimenopause, and these are not explained by advancing age alone. When occur, levels remain within normal limits for all a very number of Women’s experience brain fog extends beyond complaints, reflecting the negative effect on broad range abilities. Clinicians can counsel about...
Objective There has been limited research on accurate staging of the menopausal transition in sub-Saharan African women. Our aim was to assess usefulness Stages Reproductive Aging Workshop + 10 (STRAW 10) criteria ovarian aging black South women, examining whether obesity any effect transition. Methods The study enrolled 702 women aged 40 60 years. STRAW were used categorize stages reproductive aging. Menopause Rating Scale measure prevalence vasomotor symptoms. Follicle-stimulating hormone...
Developing countries are disproportionately affected by hypertension, with Black women being at greater risk, possibly due to differences in body fat distribution. The objectives of this study were: (1) To examine how different measures composition associated blood pressure (BP) and incident hypertension; (2) determine the association between baseline or change composition, (3) which measure best predicts hypertension South African women. sample comprised 478 non-hypertensive women, aged...
Objective: Studies, conducted largely in North America and Europe, demonstrate that menopausal symptoms stage influence cognitive function. Here, we evaluate these associations a large cohort of sub-Saharan African women, population where are understudied. We hypothesized premenopausal women would show better performance than later the transition, be inversely related to cognition.Methods: This cross-sectional study included 702 black urban South between ages 40 60 years from Study Women...
Abstract Objective The aim of the study is to identify suitable definitions and patient-reported outcome measures (PROMs) assess each six core outcomes previously identified through COMMA (Core Outcomes in Menopause) global consensus process relating vasomotor symptoms: frequency, severity, distress/bother/interference, impact on sleep, satisfaction with treatment, side effects. Methods A systematic review was conducted relevant for side-effects PROMs acceptable measurement properties...
Menopause transition is associated with accelerated bone loss, though data are limited from sub-Saharan African (SSA). Our objective was to describe density, geometry and estimated strength in women by menopause status explore whether patterns differed within those living HIV.Radius tibia peripheral QCT were collected for Black South (n = 430) aged 40-61 years verified HIV status. pQCT outcomes distal 4 % radius total cross-sectional area (CSA), volumetric mineral density (vBMD), compressive...
Gluteofemoral fat correlates negatively with a number of cardiometabolic disease risk factors, but the mechanisms involved in these relationships are unknown. The aim this study was to test hypothesis that gluteofemoral attenuates by increasing blood adiponectin levels. This cross-sectional which arm, leg, gluteofemoral, abdominal s.c. and visceral levels were measured dual-energy X-ray absorptiometry 648 African females. Fasting serum adiponectin, lipid, insulin plasma glucose pressure...
Stress is ubiquitous in everyday life, and chronic stress can have negative consequences for health social welfare. Although a growing body of research addresses the relationships between stress, health, quality there gap literature with regard to effects among women at midlife. The purpose this commentary provide brief history research, including various methods measuring stress; discuss physiological review relevant studies about midlife order identify unanswered questions stress. This...
Objective: Developing countries are disproportionately affected by hypertension, with Black women being at greater risk, possibly due to differences in body fat distribution. The aims of this study were: (1) To examine how different measures composition associated blood pressure (BP) and incident hypertension; (2) determine the association between baseline- or change (3) which measure best predicts hypertension South African women. Design method: sample comprised 478 non-hypertensive women,...
Objective: The objectives of this study were: (1) to examine how different measures body composition are associated with blood pressure (BP) and incident hypertension; (2) determine the association between baseline or change in composition, (3) which measure best predicts hypertension Black South African women. Design Method: sample comprised 478 non-hypertensive women, aged 29–53 years. Body fat BP were assessed at 8.3 years later. was using dual-energy X-ray absorptiometry (DXA)...