A5049805815- Reproductive Health and Contraception
- Cervical Cancer and HPV Research
- Menopause: Health Impacts and Treatments
- Bone health and osteoporosis research
- Global Maternal and Child Health
- Hepatitis B Virus Studies
- Maternal and fetal healthcare
- Genital Health and Disease
- Hip and Femur Fractures
- Menstrual Health and Disorders
- Maternal and Perinatal Health Interventions
- Estrogen and related hormone effects
- Phytoestrogen effects and research
- Ovarian function and disorders
- Sexual function and dysfunction studies
- Endometriosis Research and Treatment
- Bone Metabolism and Diseases
- Gestational Diabetes Research and Management
- COVID-19 Impact on Reproduction
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Cardiac, Anesthesia and Surgical Outcomes
- Delphi Technique in Research
- Bone health and treatments
- Reproductive tract infections research
Chulalongkorn University
2015-2024
Otto-von-Guericke University Magdeburg
2024
King Chulalongkorn Memorial Hospital
2015-2024
Faculty (United Kingdom)
2001
Hip fracture is a major public health problem. Earlier studies projected that the total number of hip will increase dramatically by 2050, and most occur in Asia. To date, only few provided updated projection, none them focused on projection Thus, it essential to provide up date prediction Asia, evaluate direct medical cost We 9 Asian Federation Osteoporosis Societies members using incidence rate population size. show from 1,124,060 2018 2,563,488 2.28-fold increase. This mainly due changes...
The control arm of PATRICIA (PApilloma TRIal against Cancer In young Adults, NCT00122681) was used to investigate the risk progression from cervical HPV infection intraepithelial neoplasia (CIN) or clearance infection, and associated determinants.Women aged 15-25 years were enrolled. A 6-month persistent (6MPI) defined as detection same type at two consecutive evaluations over 6 months ≥2 type-specific negative samples taken intervals approximately following a positive sample. primary...
In the Phase III PATRICIA study (NCT00122681), human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine (Cervarix(®), GlaxoSmithKline Biologicals) was highly efficacious against HPV-16/18 infections and precancerous lesions in women deoxyribose nucleic acid (DNA) negative seronegative at baseline. We present further data on efficacy (VE) total vaccinated cohort including who may have been exposed to infection before vaccination. with no evidence of current or previous (DNA seronegative), VE...
ABSTRACT We report final event-driven analysis data on the immunogenicity and efficacy of human papillomavirus 16 18 ((HPV-16/18) AS04-adjuvanted vaccine in young women aged 15 to 25 years from PApilloma TRIal against Cancer In Adults (PATRICIA). The total vaccinated cohort (TVC) included all randomized participants who received at least one dose (vaccine, n = 9,319; control, 9,325) months 0, 1, and/or 6. TVC-naive 5,822; 5,819) had no evidence high-risk HPV infection baseline, approximating...
We evaluated the efficacy of human papillomavirus (HPV)−16/18 AS04‐adjuvanted vaccine in preventing HPV‐related disease after surgery for cervical lesions a post‐hoc analysis PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681). Healthy women aged 15–25 years were randomized (1:1) to receive or control at months 0, 1 and 6 followed 4 years. Women enrolled regardless their baseline HPV DNA status, HPV‐16/18 serostatus, cytology, but excluded if they had previous planned...
We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on association between behavioral risk factors and HPV infection cervical abnormalities.Women completed questionnaires at baseline. Prevalence of abnormalities (detected by cytological or histological procedures) with were analyzed univariate stepwise multivariable logistic regressions.16782 women questionnaires. Among 16748 for infection, 4059 (24.2%) infected any type. 16757...
Objective To determine the age-specific and age-adjusted prevalence of osteopenia osteoporosis in pre-and postmenopausal Thai women. Methods This was a descriptive study 1,935 women ranging age from 40 to 80 years, with randomly selected strata using multistage sampling stratifying six representative provinces country. After recruiting, all were interviewed by well-trained interviewer structured questionnaires. Bone mineral density (BMD) lumbar spine 1-4 nondominant hip measured dual energy...
The aim of this study was to demonstrate the efficacy an ultra-low-dose vaginal estriol 0.03 mg in combination with viable Lactobacillus acidophilus KS400 (Gynoflor(®) tablets) short-term therapy and investigate long-term maintenance dose treatment atrophy.This a double-blind, randomized, placebo-controlled (Controlled phase--initial therapy) followed by open-label follow-up (Open phase--test medication initial therapy). Included were postmenopausal women atrophy symptoms Vaginal Maturation...
We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment PATRICIA (Papilloma Trial Against Cancer Young Adults; NCT00122681).Using Poisson regression, we compared associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) the control arm (DNA negative baseline for corresponding [HPV-16: n = 8193; HPV-18: 8463]).High titers naturally acquired HPV-16 antibodies and/or...
As silent and preventable in nature, postmenopausal osteoporosis awareness should be raised among young women prior to an irreversible period of declining bone mass. We therefore decided assess the inter-correlation knowledge, attitude preventive behaviors around age peak A cross-sectional study was conducted 430 aged 20–35 years. The participants’ concerning prevention were assessed along with demographic data using a four-part questionnaire. items this questionnaire established by...
Abstract Objective: Genitourinary symptoms, such as vaginal dryness and pain with sex, are commonly experienced by postmenopausal women. Comparing treatments for these genitourinary symptoms restricted the use of different outcome measures in clinical trials omission outcomes, which may be relevant to The aim this project was develop a Core Outcome Set (COS) reported associated menopause. Methods: We performed systematic review randomized controlled menopause extracted their outcomes. This...
Vasomotor symptoms (VMS) (hot flashes and night sweats) affect most women over the menopause transition. Comparing safety effectiveness of treatments for vasomotor is limited by use inconsistent outcome measures, uncertainty as to which outcomes are important symptomatic women. To address this, we have developed a Core Outcome Set (COS) in clinical trials VMS.We systematically reviewed primary measured randomized controlled VMS. These were refined entered into two-round modified Delphi...
This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations effective management of this chronic condition. The primary focus is achieving optimal fracture prevention through a comprehensive, individualized approach. A panel experts convened develop statements by synthesizing current literature leveraging clinical expertise. review encompassed anti-osteoporosis medication goals, first-line treatments...
More information is needed about time between sexual initiation and human papillomavirus (HPV) infection development of cervical precancer.The objectives were to investigate the first activity detection HPV or intraepithelial neoplasia (CIN), associated factors in women from double-blind, multinational, 4-year PATRICIA trial. enroled aged 15-25 years with no more than 6 lifetime partners. Women randomized 1:1 HPV-16/18 AS04-adjuvanted vaccine control, but only control arm who began...
Objectives Significant differences in the prevalence of menopausal symptoms and lipid profiles have previously been reported for nine ethnic groups postmenopausal Asian women participating Pan-Asia Menopause (PAM) study. Based on these findings, we tested hypothesis that reproductive hormone differ among under investigation PAM study.Methods Baseline serum samples from (n = 1020) representing were analyzed at a central laboratory by electro-chemiluminescence immunoassay methods. Hormone...
To identify the prevalence of female pattern hair loss (FPHL), characteristics, and associated factors in healthy postmenopausal women.Two hundred women aged 50 to 65 years were recruited. Each participant was evaluated for FPHL according Ludwig's classification using standardized global photography all six views trichoscopy density diameter. Three dermatologists re-evaluated pictures confirmation FPHL. The time since menopause, levels scalp sebum, serum testosterone, estradiol, thyroid...