Godfred Agongo
A5079762351- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Global Public Health Policies and Epidemiology
- Gut microbiota and health
- Mosquito-borne diseases and control
- Probiotics and Fermented Foods
- Atherosclerosis and Cardiovascular Diseases
- Chronic Disease Management Strategies
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
C.K. Tedam University of Technology and Applied Sciences
2022-2025
Navrongo Health Research Centre
2016-2025
Ghana Health Service
2019-2025
Utrecht University
2023
Georgetown University
2023
University of the Witwatersrand
2016-2020
National Health Laboratory Service
2016-2020
University for Development Studies
2014
H3Africa is developing capacity for health-related genomics research in Africa
Population studies provide insights into the interplay between gut microbiome and geographical, lifestyle, genetic environmental factors. However, low- middle-income countries, in which approximately 84% of world's population lives1, are not equitably represented large-scale research2-4. Here we present AWI-Gen 2 Microbiome Project, a cross-sectional study sampling 1,801 women from Burkina Faso, Ghana, Kenya South Africa. By engaging with communities that range rural horticultural to...
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic environmental factors that influence body composition, fat distribution CMD risk, with the aim provide insights towards effective treatment intervention strategies. It provides research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya South Africa. Following process involved...
There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result increasingly urbanized lifestyle characterized by the growing consumption processed calorie-dense food, combined with physical inactivity more sedentary behaviour. While link between public health has been extensively studied in Caucasian African American populations, few studies have conducted paper describes detailed methods for Phase 1 AWI-Gen study that were used to...
BackgroundRapid epidemiological health transitions occurring in vulnerable populations Africa that have an existing burden of infectious and non-communicable diseases predict increased risk consequent prevalence kidney disease. However, few studies characterised the true damage associated factors Africans. We investigated markers for known rural urban settings sub-Saharan Africa.MethodsIn this cross-sectional population study (Africa Wits-International Network Demographic Evaluation...
Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist hunter-gatherer societies. The scarcity of between these extremes limits our understanding how the microbiota relates health disease majority world's population. Here, we evaluate composition transitioning South African using short- long-read sequencing. We analyze stool from adult females rural Bushbuckridge (n = 118) or urban Soweto 51) find that...
Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns of with hypertension among 30 044 continental Africans. harmonized data on (defined as previous diagnosis/use antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) from individuals Cardiovascular H3Africa Innovation Resource across 13 African countries. analyzed population-based...
Understanding the epidemiology of asymptomatic Plasmodium falciparum infections is critical for countries to move toward malaria elimination. Using different methods parasite detection, we evaluated how seasonality, spatial location, and other factors affect age-specific in Bongo District, Ghana. Asymptomatic prevalence by microscopy decreased significantly from 42.5% at end wet 27.5% dry season (P < 0.001). 18S rRNA polymerase chain reactions (PCRs), all microscopy-negative samples were...
Background: African populations are characterised by diversity at many levels including: demographic history, genetic ancestry, language, wealth, socio-political landscape, culture and behaviour. Several of these have a profound impact on body fat mass. Obesity, key risk factor for cardiovascular metabolic diseases, in the wake epidemiological health transitions across continent, requires detailed analysis together with other major factors.Objective: To compare regional sex-specific mass...
Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its involvement the metabolism of ~ 25% clinically prescribed medications. The encoding CYP2D6 gene highly polymorphic, and many pharmacogenetics studies have been performed worldwide investigate distribution star alleles (haplotypes); however, African populations relatively understudied date. In this study, distributions predicted metabolizer phenotypes—derived from activity scores—were examined across multiple...
Objectives To determine the prevalence of multimorbidity, to identify which chronic conditions cluster together and factors associated with a greater risk for multimorbidity in sub-Saharan Africa (SSA). Design Cross-sectional, multicentre, population-based study. Setting Six urban rural communities four African countries. Participants Men (n=4808) women (n=5892) between ages 40 60 years from AWI-Gen Measures Sociodemographic anthropometric data, as defined by presence two or more following...
Introduction The contribution of obesity phenotypes to dyslipidaemia in middle-aged adults from four sub-Saharan African (SSA) countries at different stages the epidemiological transition has not been reported. We characterized lipid levels and investigated their relation with growing burden SSA countries. Methods A cross-sectional study was conducted Burkina Faso, Ghana, Kenya South Africa. Participants were middle aged adults, 40–60 years old residing sites for past 10 years....
Abstract Aims/hypothesis Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes other cardiometabolic diseases. Genetic association studies have identified hundreds associations for each glycaemic trait, yet very few involved continental African populations. We report results genome-wide (GWASs) in a pan-African cohort four traits, namely glucose, insulin, (HOMA-IR) beta cell function (HOMA-B), which quantitative...
Objectives We investigated progression through the care cascade and associated factors for people with diabetes in sub-Saharan Africa to identify attrition stages that may be most appropriate targeted intervention. Design Cross-sectional study. Setting Community-based study four African countries. Participants 10 700 individuals, aged 40–60 years. Primary secondary outcome measures The primary measure was of defined as age-adjusted prevalence (self-report diabetes, fasting plasma glucose...
Abstract Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel significant signals (p < 5E-08): systolic BP near...
Dyslipidaemia is a primary risk factor for cardiometabolic disease, causing over 17 million deaths globally in 2015. However, the burden of dyslipidaemia and factors associated with lipid levels remain unknown many rural African populations. Therefore, this study evaluated association socio-demographic, anthropometric behavioural Ghana. The prevalence hypercholesterolaemia, hypertriglyceridaemia elevated LDL-C total population 1839 (846 men 993 women) was 4.02%, 2.12%, 5.55% respectively did...
Obesity and associated cardiometabolic diseases are increasing in urban sub-Saharan Africa due to a complex epidemiological nutritional transition. Related data on rural communities is scarce.
Plasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin. We hypothesized in malaria-endemic areas, parasites vary invasion pathways under immune pressure. Therefore, mechanisms clinical isolates collected from 3 zones Ghana different levels endemicity (from lowest to highest, Accra, Navrongo, Kintampo) were compared standardized methods.Blood samples children aged...
The analysis of the effects autozygosity, measured as change mean value a trait among offspring genetic relatives, reveals existence directional dominance or overdominance. In this study we detect evidence effect autozygosity in 4 out 13 cardiometabolic disease-associated traits using data from more than 10,000 sub-Saharan African individuals recruited Ghana, Burkina Faso, Kenya and South Africa. on these phenotypes is found to be sex-related, with inbreeding having significant decreasing...
Atherosclerosis precedes the onset of clinical manifestations cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 60 years) resident four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping performed on H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), FBXL17 2.5E-08), were...
Background and objectives Recessive inheritance of African-specific APOL1 kidney risk variants is associated with higher nondiabetic disease, progression to failure, early-onset albuminuria that precedes eGFR decline. The effect on disease in continental Africans understudied. Objectives this study were determine allele prevalence associations between genotypes West, East, South Africa. Design, setting, participants, & measurements This cross-sectional population-based four African...