A5054345745- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Reproductive tract infections research
- Genomics and Rare Diseases
- Cancer Risks and Factors
- Hepatitis B Virus Studies
- Obesity, Physical Activity, Diet
- Genetics, Bioinformatics, and Biomedical Research
- Genital Health and Disease
- Global Cancer Incidence and Screening
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Physical Activity and Health
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Consumer Attitudes and Food Labeling
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Global Health and Surgery
- RNA Research and Splicing
- Gynecological conditions and treatments
University of Maryland, Baltimore
2012-2025
University of Ibadan
2017-2025
U-M Rogel Cancer Center
2017-2024
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2017-2024
University of Baltimore
2023
National Cancer Institute
2022
Division of Cancer Epidemiology and Genetics
2022
Institute of Human Virology
2011-2019
National Hospital Abuja
2016-2018
National Human Genome Research Institute
2016-2018
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique features, clinically significant subtypes, potential therapeutic targets. found 61 somatic copy-number alterations (SCNAs) 46 significantly mutated genes (SMGs). Eleven SCNAs 11 SMGs had not been identified in previous TCGA studies the individual tumor types. functionally estrogen receptor-regulated long non-coding RNAs (lncRNAs)...
Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome composition relation to type 2 (T2D) Africans. Here, we describe profile nondiabetic adults and investigate association between microbiota T2D urban West was determined 291 Nigerians (98 T2D, 193 non-T2D controls) using fecal 16S V4 rRNA gene sequencing done on Illumina MiSeq platform. Data analysis operational taxonomic units (OTU)...
Genetic variants that underlie susceptibility to cervical high-risk human papillomavirus (hrHPV) infections are largely unknown. We conducted discovery genome-wide association studies (GWAS), replication, meta-analysis and colocalization, generated polygenic risk scores (PRS) examined the of classical HLA alleles hrHPV in a cohort over 10,000 women. identified significant for prevalent around LDB2 persistent near TPTE2, SMAD2, CDH12, which code proteins significantly expressed endocervix....
Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns of with hypertension among 30 044 continental Africans. harmonized data on (defined as previous diagnosis/use antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) from individuals Cardiovascular H3Africa Innovation Resource across 13 African countries. analyzed population-based...
Recent studies have suggested that the vaginal microenvironment plays a role in persistence of high-risk human papillomavirus (hrHPV) infection and thus cervical carcinogenesis. Furthermore, it has been shown some mycoplasmas are efficient methylators may facilitate carcinogenesis through methylation hrHPV somatic cells. We examined associations between prevalence Mycoplasma spp. microbiota, prevalent as well persistent infections.We 194 Nigerian women who were tested for using SPF25/LiPA10...
Abstract Background Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D remain scarce outside Europe and North America. The aims this study are use an untargeted metabolomics approach identify: (a) metabolites that differentially expressed between individuals with without (b) a metabolic signature associated population Sub-Saharan Africa (SSA). Methods A total 580 adult Nigerians from...
Background: The prevalence, persistence and multiplicity of HPV infection, appears different comparing HIV positive to negative women. In this study, we examined prevalent, persistent multiple low- high-risk cervical infections in Methods: We studied 1,020 women involved a study infection using SPF25/LiPA10. Two visits were scheduled, at enrollment six months afterwards. At each visit, research nurses used brush collect samples exfoliated cells from the os, all participants. Exact logistic...
Background: There is exponential growth in the interest and implementation of genomics research Africa. This has been facilitated by Human Hereditary Health Africa (H3Africa) initiative, which aims to promote a contemporary approach study environmental determinants common diseases African populations.Objective: The purpose this article describe important challenges affecting Africa.Methods: observations, recommendations presented were obtained through discussions scientists at...
Health decision models are the only available tools designed to consider lifetime natural history of human papillomavirus (HPV) infection and pathogenesis cervical cancer, estimated long-term impact preventive interventions. Yet health modeling results often considered a lesser form scientific evidence due inherent needs rely on imperfect data make numerous assumptions extrapolations regarding complex processes. We propose new framework that de-emphasizes cytologic-colposcopic-histologic...
Abstract Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for special challenges studies admixed populations. Here, we present admix-kit, an integrated toolkit pipeline analyses Admix-kit implements a suite methods to facilitate genotype phenotype simulation,...
Background and Purpose— Lower plasma magnesium levels may be associated with higher blood pressure endothelial dysfunction, but sparse prospective data are available for stroke. Methods— Among 32 826 participants in the Nurses’ Health Study who provided samples 1989 to 1990, incident ischemic strokes were identified confirmed by medical records through 2006. We conducted a nested case–control analysis of 459 cases, matched 1:1 controls on age, race/ethnicity, smoking status, date draw,...
To identify predominant dietary patterns in four African populations and examine their association with obesity.Cross-sectional study.Setting/SubjectsWe used data from the Africa/Harvard School of Public Health Partnership for Cohort Research Training (PaCT) pilot study established to investigate feasibility a multi-country longitudinal non-communicable chronic disease sub-Saharan Africa. We applied principal component analysis intake collected an FFQ developed PaCT ascertain Tanzania, South...
Intakes of magnesium, potassium, and calcium have been inversely associated with the incidence hypertension, a known risk factor for stroke. However, only few studies examined intakes these cations in relation to stroke.The aim this study was investigate whether high intake is reduced stroke among men.We prospectively associations between from diet supplements, incident 42 669 men Health Professionals Follow-up Study, aged 40 75 years free diagnosed cardiovascular disease cancer at baseline...
Increasing noncommunicable diseases in Nigeria are partly related to dietary factors. However, the lack of validated nutrition assessment tools hinders conduct nutritional epidemiology research this population.
BACKGROUND: Stroke incidence is decreasing in older ages but increasing young adults. These divergent trends are at least partially attributable not only to diverging stroke risk factors may also be due differences the impact of different ages. To address this latter possibility, we used Mendelian randomization assess association between early-onset ischemic ([EOS]; onset 18–59 years) and late-onset ([LOS]; ≥60 years). METHODS: We identified genetic variants from GWAS Catalog for use as...
Abstract Background Poor diet quality is a significant and modifiable risk factor associated with numerous non-communicable diseases. Despite its critical importance, there paucity of comprehensive data concerning in Nigeria. In this study, we evaluated the healthiness food intake among Nigerian adults to identify factors them seasonal variations consumption patterns. Methods We used validated semi-quantitative Food Frequency Questionnaire (FFQ). collect dietary from Ibadan, Nigeria, on four...
Why was the cohort set up?Globally, cervical cancer is fourth most common among women, with an estimated 528 000 new cases in 2012. 1 Although it remains a significant public health problem worldwide, burden of falls disproportionately on low-resource countries.In USA, incidence rate 6.6 per 100 2012, compared 23.0 Nigeria 2 which had about half population USA 2012.Persistent high-risk human papillomavirus (hrHPV) infection cervix necessary cause cancer. 3,4About 80% sexually active...
Genital warts are important causes of morbidity and their prevalence incidence can be used to evaluate the impact HPV vaccination in a population.
Abstract The vaginal microbiota is thought to play a role in modulating risk of high-risk human papillomavirus (hrHPV) infection. We examined the relationship between and persistent hrHPV infection HIV-negative HIV-positive women. used 16S-rRNA sequencing characterize two serial samples taken six months apart from 211 Nigerian women (67%, 142/211 33%, 69/211 HIV-negative) evaluated association using generalized estimating equation logistic regression models linear discriminant analysis...