A5068332189- Research on Leishmaniasis Studies
- Malaria Research and Control
- Genomics and Rare Diseases
- Trypanosoma species research and implications
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Forensic and Genetic Research
- Mosquito-borne diseases and control
- Genomic variations and chromosomal abnormalities
- Hemoglobinopathies and Related Disorders
- Parasites and Host Interactions
- Genetic diversity and population structure
- Race, Genetics, and Society
- Genetics, Bioinformatics, and Biomedical Research
- Viral-associated cancers and disorders
- Forensic Anthropology and Bioarchaeology Studies
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Biochemical and Molecular Research
- Neurological diseases and metabolism
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Evolution and Genetic Dynamics
- Epigenetics and DNA Methylation
University of Khartoum
2016-2025
Suez Canal University
2024
Hamad Medical Corporation
2023
BGI Group (China)
2022
Cairo University
2022
Kathmandu University
2022
Children Cancer Hospital
2022
UNESCO
2022
Universidade Federal do Rio de Janeiro
2022
Al-Neelain University
2022
Africa is the source of all modern humans, but characterization genetic variation and relationships among populations across continent has been enigmatic. We studied 121 African populations, four American 60 non-African for patterns at 1327 nuclear microsatellite insertion/deletion markers. identified 14 ancestral population clusters in that correlate with self-described ethnicity shared cultural and/or linguistic properties. observed high levels mixed ancestry most reflecting historical...
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade effects chemotherapeutics and one most pressing major dilemmas in therapy. Chemotherapy can arise due several host or tumor-related factors. However, current research focused on tumor-specific factors specifically genes that handle expression pumps efflux accumulated drugs inside malignantly transformed types cells. In this work, we suggest a wider alternative perspective sets stage for future...
H3Africa is developing capacity for health-related genomics research in Africa
Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, their intracellular alkaline pH (pH i).This effect is part of the metabolic alterations found in most, if not all, cancer deal with unfavorable conditions, mainly hypoxia and low nutrient supply, order preserve its evolutionary trajectory production lactate after ten steps glycolysis.Thus, reprogram cellular metabolism way that gives them thermodynamic advantage.Tumors exist within highly heterogeneous...
In humans, the ability to digest lactose, sugar in milk, declines after weaning because of decreasing levels enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high amounts and are able lactose into adulthood (i.e., they have lactase-persistence [LP] trait). It is thought that selection has played a major role maintaining this genetically determined phenotypic trait different human populations practice pastoralism. To identify variants associated with LP...
Genome-wide association studies (GWAS) provide a powerful means of identifying genetic variants that play role in common diseases. Such present important ethical challenges. An increasing number GWAS is taking place lower income countries and there pressing need to identify the particular challenges arising such contexts. In this paper, we draw upon experiences MalariaGEN Consortium specific issues raised by research Africa, Asia Oceania. We explore three key areas: protecting interests...
The idea that all modern humans share a recent (within the last 150, 000 years) African origin has been proposed and supported on basis of three observations. Most genetic loci examined to date have (1) shown greater diversity in populations than others, (2) placed first branch between non-African phylogenetic trees, (3) indicated dates for either molecular coalescence (with exception some autosomal X-chromosomal loci) or time separation populations. We analyze variation at 10 Y chromosome...
Anopheles arabiensis is the major vector of malaria in Ethiopia. Malaria control Ethiopia based on selective indoor residual spraying using DDT, distribution long lasting insecticide treated nets and environmental management larval breeding habitats. DDT pyrethroid insecticides are neurotoxins have a similar mode action sodium ion channel insects. It was therefore necessary to verify susceptibility status An. arabiensis, better understand cross-resistance between pyrethroids this species as...
Breast cancer is the commonest in Sudanese women. Reported genetic alterations form of mutations tumor suppressors are low frequencies and could not explain peculiarities diseases including its focal nature. Potential contributors disease aetiology include oncogenic viruses such as Epstein-Barr virus (EBV), an established culprit nasopharyngeal carcinoma, one most frequent cancers Sudan.In this study, DNA was extracted from malignant tissue samples healthy tumour-free same breast. Polymerase...
Abstract We study the major levels of Y‐chromosome haplogroup variation in 15 Sudanese populations by typing Y‐haplogroups 445 unrelated males representing three linguistic families Sudan. Our analysis shows fall into haplogroups A, B, E, F, I, J, K, and R frequencies 16.9, 7.9, 34.4, 3.1, 1.3, 22.5, 0.9, 13% respectively. Haplogroups E occur mainly Nilo‐Saharan speaking groups including Nilotics, Fur, Borgu, Masalit; whereas are more frequent among Afro‐Asiatic Arabs, Beja, Copts, Hausa,...
Intratumoral evolution produces extensive genetic heterogeneity in clinical cancers. This is generally attributed to an increased mutation rate that continually new genetically defined clonal lineages. Equally important are the interactions between heritable traits of cancer cells and their microenvironment natural selection favoring some 'species' over others. That is, while mutations produce variation, environmental cellular adaptation govern strategies (and genotypes) can proliferate...
Anatomically modern humans arose in Africa ∼300,000 years ago, but the demographic and adaptive histories of African populations are not well-characterized. Here, we have generated a genome-wide dataset from 840 Africans, residing western, eastern, southern, northern Africa, belonging to 50 ethnicities, speaking languages four language families. In addition agriculturalists pastoralists, our study includes 16 that practice, or until recently practiced, hunting-gathering (HG) lifestyle. We...