A5039050716- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Eosinophilic Disorders and Syndromes
- Diabetes Treatment and Management
- Leptospirosis research and findings
- Diabetes Management and Research
- T-cell and Retrovirus Studies
- Tuberculosis Research and Epidemiology
- Virology and Viral Diseases
- Malaria Research and Control
- Diagnosis and treatment of tuberculosis
- Actinomycetales infections and treatment
- Bone Tumor Diagnosis and Treatments
- Renal Diseases and Glomerulopathies
- Brucella: diagnosis, epidemiology, treatment
- Head and Neck Surgical Oncology
- Bartonella species infections research
- Lymphoma Diagnosis and Treatment
- Pleistocene-Era Hominins and Archaeology
- Autoimmune Bullous Skin Diseases
- Synthesis and Biological Evaluation
- Viral-associated cancers and disorders
- Forensic Anthropology and Bioarchaeology Studies
- Immune responses and vaccinations
King Faisal University
1987-2025
University of Ha'il
2022-2025
University of Khartoum
2011-2024
Southwestern Medical Center
2019
The University of Texas Southwestern Medical Center
2019
National Ribat University
2017
St. Joseph Medical Center in Tacoma
2015
Trinity Hospital of Augusta
2015
St. Joseph Hospital
2015
Sudan University of Science and Technology
2015
From the early 1900s, visceral leishmaniasis (VL; kala-azar) has been among most important health problems in Sudan, particularly main endemic area eastern and central regions. Several major epidemics have occurred, recent--in Western Upper Nile province southern detected 1988--claiming over 100,000 lives. The disease spread to other areas that were previously not known be for VL. A upsurge number of cases was noted area. These events triggered renewed interest disease. Epidemiological...
We have found that an important Th2 cytokine, IL-10, is produced by tissues from patients acutely infected with Leishmania donovani. In all individuals tested, IL-10 mRNA production was increased in lymph nodes taken during acute disease over observed postacute samples. contrast, both pre- and posttreatment had readily detected for IFN-gamma IL-2. A down-regulating effect of on leishmania-induced proliferative responses demonstrated when Hu rIL-10 added to cultures PBMC clinically cured...
"Endemic Kala-Azar in Eastern Sudan: A Longitudinal Study on the Incidence of Clinical and Subclinical Infection Post-Kala-Azar Dermal Leishmaniasis" published Dec 1994 by The American Society Tropical Medicine Hygiene.
Abstract IL-12 is a pluripotent cytokine that interacts with NK and T cells to play central role in the initiation maintenance of Th1 responses IFN-gamma production. Because interactive relationship between response infectious organisms, study was undertaken examine immune regulation human visceral leishmaniasis (VL). Human (Hu) VL associated dysfunction appearance IL-10 mRNA, not present healed individuals. We found PBMC from treated patients produced both p40 vitro stimulation Leishmania...
We compared a strip test employing recombinant K39 (rK39) antigen and protein A/colloidal gold as read‐out agents with the rK39 ELISA for IgM IgG antibodies direct agglutination (DAT) using 55 sera from patients parasitologically confirmed visceral leishmaniasis (VL). The was positive in 37/55 (67%), DAT 50/55 (91%) at ≥ 1 : 1600 cut‐off value 47/55 (85%) 6400 value. rK39‐ELISA gave results all sera; those who had significantly higher levels than negative (31.1 (SD=3.6) 17.7 U/ml (SD=9.8),...
In a comparative study 88 patients were diagnosed as suffering from kala-azar (visceral leishmaniasis) using 3 parasitological methods simultaneously. Splenomegaly was absent in 4 cases. 84 with splenomegaly, splenic aspiration appeared to be the most sensitive method (96.4%), followed by bone marrow (70.2%) and lymph node (58.3%). There no relation between titres direct agglutination test parasite load determined number of which positive or density aspirates. Splenic compared an assessment...
Background Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious VL treatment India. Methods A multi-centre randomized-controlled trial (RCT) compare efficacy and safety of PM (20 mg/kg/day 21 days) plus sodium stibogluconate (SSG) combination (PM, 15 SSG, 20 17 with SSG 30 Patients aged 4–60 years parasitologically confirmed were enrolled, excluding patients contraindications. Primary secondary outcomes...
Background Visceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease fatal, available treatment expensive and often toxic, drug resistance increasing. Improved options are needed. Paromomycin was shown to be an efficacious first-line with low toxicity India. Methods This 3-arm multicentre, open-label, randomized, controlled clinical trial compare three regimens for VL East Africa: paromomycin sulphate (PM) at 15 mg/kg/day 21 days versus sodium...
Sudanese mucosal leishmaniasis is a chronic infection of the upper respiratory tract and/or oral mucosa caused mainly by Leishmania donovani. The disease occurs in areas country endemic for visceral leishmaniasis, particularly among Masalit and other closely related tribes western Sudan. condition may develop during or after an attack but most cases it primary disease. Unlike South American mucocutaneous Sudan not preceded accompanied cutaneous lesion. Pathologically, lesions show mixture...
An evaluation of Leishmania PCR was performed with bone marrow, lymph node, and blood samples from 492 patients, 60 positive controls, 90 negative controls. Results were compared microscopy results for Giemsa-stained smears. node marrow aspirates patients microscopically confirmed visceral leishmaniasis (VL) equally sensitive. However, in clinically suspected having VL whom parasites could not be demonstrated by microscopy, 12 23 (52.2%) 8 (66.7%) aspirates, thus confirming the clinical...
Abstract Some patients develop post-kala-azar dermal leishmaniasis (PKDL) after they have been treated for the systemic infection kala-azar (visceral leishmaniasis). It has an enigma why parasites cause skin symptoms successfully disease. We report here that PKDL development can be predicted before treatment of visceral leishmaniasis, and IL-10 is involved in pathogenesis. Before Leishmania were present which appeared normal on all patients. However, was detected keratinocytes and/or sweat...
ABSTRACT The rK39 enzyme-linked immunosorbent assay (ELISA) was compared with the direct agglutination test (DAT) for Leishmania donovani infection in Sudan. ELISA proved more sensitive than DAT diagnosis of kala-azar (93 and 80%, respectively); both tests may remain positive up to 24 months after treatment. For patients post-kala-azar dermal leishmaniasis individuals subclinical infection, performed as well but could detect 6 earlier ∼40% patients. Conversion also occurred leishmanin skin...
Journal Article Immunochemotherapy of persistent post-kala-azar dermal leishmaniasis: a novel approach to treatment Get access Ahmed Mudawi Musa, Musa aInstitute Endemic Diseases, University Khartoum, Sudan Search for other works by this author on: Oxford Academic PubMed Google Scholar Eltahir Awad Gasim Khalil, Khalil * *Corresponding author. Present address: Department Clinical Pathology and Immunology, Institute P.O. Box 45235, Sudan. Tel.: +249 83 779712; fax: 779712. E-mail...
Journal Article The safety and efficacy of itraconazole for the treatment patients with eumycetoma due to Madurella mycetomatis Get access A.H. Fahal, Fahal ⁎ aMycetoma Research Centre, University Khartoum, Sudan ⁎Corresponding author. E-mail address:ahfahal@hotmail.com (A.H. Fahal). Search other works by this author on: Oxford Academic PubMed Google Scholar I.A. Rahman, Rahman A.M. El-Hassan, El-Hassan M.E. Abdel E.L. E.E. Zijlstra bDepartment Medicine, Erasmus Medical Rotterdam,...
A recent study has shown that treatment of visceral leishmaniasis (VL) with the standard dose 15 mg/kg/day paromomycin sulphate (PM) for 21 days was not efficacious in patients Sudan. We therefore decided to test efficacy paramomycin a longer duration (15 28 days) and at higher 20 days.This randomized, open-label, dose-finding, phase II assessed two above high-dose PM regimens. Patients clinical features positive bone-marrow aspirates VL were enrolled. All received their assigned courses...
Breast cancer is the commonest in Sudanese women. Reported genetic alterations form of mutations tumor suppressors are low frequencies and could not explain peculiarities diseases including its focal nature. Potential contributors disease aetiology include oncogenic viruses such as Epstein-Barr virus (EBV), an established culprit nasopharyngeal carcinoma, one most frequent cancers Sudan.In this study, DNA was extracted from malignant tissue samples healthy tumour-free same breast. Polymerase...
Background Anti-leishmanial drug regimens that include a single dose AmBisome® could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate is unknown. Methodology A multi-centre, open-label, non-inferiority, randomized controlled trial an adaptive design, was conducted to compare efficacy and safety of multiple doses treatment VL in Africa. The primary endpoint definitive cure (DC) at 6 months. Symptomatic parasitologically-confirmed,...
Cutaneous leishmaniasis (CL) in Sudan is caused by Leishmania major, zymodeme LON-1. The disease endemic many parts of the country. vector Phlebotomus papatasi and animal reservoir probably Nile rat Arvicanthis niloticus. Clinically, patients usually present with papules, nodules, or nodulo-ulcerative lesions, mainly on exposed skin. In 20% cases parasite disseminates through lymphatics, producing sporotrichoid-like lesions. pathology lesion described. Langerhans cells are main...
Madurella mycetomatis is the commonest cause of eumycetoma in Sudan and other countries tropical Africa. Currently, early diagnosis mycetoma difficult. In attempting to improve identification M. and, consequently, mycetoma, we have developed specific oligonucleotide primers based on sequence internal transcribed spacer (ITS) regions spacing genes encoding fungal ribosomal RNAs. The ITS were amplified with universal sequenced, then two sets species-specific designed which specifically amplify...
Journal Article Post‐kala‐azar dermal leishmaniasis in the Sudan: clinical presentation and differential diagnosis Get access E.E. Zijlstra, Zijlstra Institute of Endemic Diseases, University Khartoum, Sudan E.E.Zijlstra, Department Medicine, College Private Bag 360, Chichiri, Blantyre 3, Malawi.E‐mail: eezijlstra@malawi.net Search for other works by this author on: Oxford Academic Google Scholar E.A.G. Khalil, Khalil P.A. Kager, Kager Infectious Tropical Medicine AIDS, Medical Centre,...
During an epidemic of visceral leishmaniasis in the Sudan, two cases congenital kala-azar were seen. The first child, whose mother had contracted southern was born Khartoum, where no transmission is currently occurring. At seven months, child fever, lymphadenopathy, and hepatosplenom-egaly; leishmania parasites detected bone marrow. died autopsy showed all tissues including lungs, kidneys, thymus. In second case, found placenta a five-month-old fetus. These demonstrate importance followup...
132 patients with suspected kala-azar (visceral leishmaniasis) were included in a prospective study to compare the performance of direct agglutination test (DAT) smears lymph node, bone marrow and splenic aspiration. A titre > 1:3200 was considered positive. 67 provided positive 65 smear-negative. Compared results obtained from smears, sensitivity DAT 94% its specificity 72%. Of 18 who negative by but DAT, 3 treated on strong clinical suspicion responded well therapy. One other patient had...
This study explores the factors influencing local residents' participation in conserving heritage, extending framework of motivation, opportunity, and ability (MOA) theory by integrating notion place attachment. focuses on level at inscribed Jubbah Town WHS, Kingdom Saudi Arabia. A self-administered questionnaire was used to collect data from a simple random sample residents subjected multiple statistical analyses for testing hypotheses. The findings PLS-SEM showed no significant...