A5001113656- Radar Systems and Signal Processing
- Advanced SAR Imaging Techniques
- Mathematical and Theoretical Epidemiology and Ecology Models
- Monoclonal and Polyclonal Antibodies Research
- Geophysical Methods and Applications
- Microwave Imaging and Scattering Analysis
- Evolution and Genetic Dynamics
- HER2/EGFR in Cancer Research
- Terahertz technology and applications
- Superconducting and THz Device Technology
- Underwater Acoustics Research
- COVID-19 epidemiological studies
- Alzheimer's disease research and treatments
- Anesthesia and Pain Management
- Inertial Sensor and Navigation
- Ultra-Wideband Communications Technology
- Nonlinear Partial Differential Equations
- Image Processing Techniques and Applications
- Analytical Chemistry and Chromatography
- Protein purification and stability
- Geophysical and Geoelectrical Methods
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Wireless Signal Modulation Classification
- Differential Equations and Numerical Methods
- Evolutionary Game Theory and Cooperation
Chinese Academy of Sciences
2014-2025
Aerospace Information Research Institute
2020-2025
Yangtze University
2024
AbbVie (United States)
2018-2024
Guizhou Botanical Garden
2024
Guilin University of Technology
2018-2023
Beijing Institute of Radio Metrology and Measurement
2023
University of Chinese Academy of Sciences
2020-2023
Fifth Affiliated Hospital of Sun Yat-sen University
2010-2022
Sun Yat-sen University
2010-2022
Onsite radar shows what lies beneath In more active periods of the Moon's history, volcanic eruptions created lava plains that formed layers dark basalt. Without subsurface probing, we can only examine most recent flows. After soft landing Chang'E-3 spacecraft, Xiao et al. made penetrating measurements lunar crust with Yutu rover. Several suggest multiple geologic processes at play throughout crustal including flows and weathering-induced creation dust rocky debris. Science , this issue p. 1226
Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) a critical coenzyme metabolism significantly reduced in brain blood samples of patients with disease (AD).To explore the measurement thiamine metabolites AD.Blood TDP, monophosphate, levels were detected using high performance liquid chromatography (HPLC). The study included exploration validation phases. In phase, 338 control subjects 43 AD utilized...
Therapeutic monoclonal antibodies (mAbs) are an important class of drugs for a wide spectrum human diseases. Liquid chromatography (LC) coupled to mass spectrometry (MS) is one the techniques in forefront comprehensive characterization analytical attributes mAbs. Among various protein modes, hydrophobic interaction (HIC) popular offline nondenaturing separation technique utilized purify and analyze mAbs, typically with use non-MS-compatible mobile phases. Herein we demonstrate first time,...
Antibody-drug conjugates (ADCs) are one of the fastest growing classes anticancer therapies. Combining high targeting specificity monoclonal antibodies (mAbs) with cytotoxic small molecule drugs, ADCs complex molecular entities that intrinsically heterogeneous. Primary sequence variants, varied drug-to-antibody ratio (DAR) species, and conformational changes in starting mAb structure upon drug conjugation must be monitored to ensure safety efficacy ADCs. Herein, we have developed a...
In the electronic countermeasure, support measure (ESM) receiver intercepts interleaved radar pulse streams, which radiates from surrounding emitters. At present, deinterleaving algorithm based on time of arrival is called repetition interval (PRI) occupies an important part ESM. The sequential difference histogram (SDIF) a well-known and effective PRI algorithm, but it has several disadvantages. When jitter missing exist in SDIF cannot estimate real value reliably, then separate trains...
The synthesis of antibody–drug conjugates (ADCs) using the interchain cysteines antibody inherently gives a mixture proteins with varying drug-to-antibody ratio. drug distribution profiles ADCs are routinely characterized by hydrophobic interaction chromatography (HIC). Because HIC is not in-line compatible mass spectrometry (MS) due to high salt levels, it laborious identify constituents peaks. An MS-compatible alternative reported here: native reversed phase liquid (nRPLC). This novel...
An essentialtask of the electronic support measures system is to deinterleave intercepted radar pulse stream. To improve radars' antijamming capability and adapt radars different application scenarios, signals emitted by various are becoming abundant, causing stream reconnaissancereceiver becomemore more complicated. Apart from fixed repetition interval (PRI) signals, other PRI modulated such as jitter staggered PRI, also appear in The aforementioned defined mixed this article....
Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs achieve better therapeutic outcomes. Comprehensive evaluation quality attributes ADCs is critical for drug development but remains challenging due heterogeneity construct. Currently, peptide mapping with reversed-phase liquid chromatography (RPLC) coupled mass spectrometry (MS) predominant approach characterize ADCs. However, it suboptimal sequence...
Alzheimer's disease (AD) is an aging-related neurodegenerative disease. The main pathological features of AD are β-amyloid protein (Aβ) deposition and tau hyperphosphorylation. Currently, there no effective drugs for the etiological treatment AD. Rifampicin (RIF) a semi-synthetic broad-spectrum antibiotic with anti-β-amyloid deposition, anti-inflammatory, anti-apoptosis, neuroprotective effects, but its application in has been limited strong hydrophobicity, high toxicity, short half-life,...
Antibody–drug conjugates (ADCs) are becoming increasingly established as a mainstream therapeutic modality for oncology, with more than dozen compounds already approved marketing and hundreds of clinical trials ongoing. ADCs hybrid construct combining, via chemical conjugation, biologic (monoclonal antibody) small-molecule (drug-linker) moieties into single drug substance. They also present significant technical strategic challenges chemistry, manufacturing, controls (CMC). Within the IQ...
In modern electronic warfare, it is a severe challenge for the Electronic Support Measure (ESM) system to realize recognition of threat radiation source, modulation pulse repetition interval (PRI) closely related function and application radar source. Therefore, PRI greatly significance identification order recognize type accurately in presence missing noise pulses, an improved algorithm based on neural network proposed this paper. paper, features describing particular are extracted from...
Aeromagnetic exploration is an important method in geophysics. The data typically measured by optically pumped magnetometer mounted on aircraft. But any aircraft produces significant levels of magnetic interference. Therefore, aeromagnetic compensation exploration. However, multicollinearity the model degrades performance compensation. To address this issue, a novel based principal component analysis proposed. Using algorithm, correlation feature matrix eliminated and components are using to...
This study examines the extent to which South Asian students in Hong Kong are gaining fluency Chinese and impact of this on their educational outcomes postcolonial context an official shift a trilingual (Cantonese, English, Putonghua) biliterate (Chinese English) society. It focuses teaching learning secondary schools "designated" for minority background students. Data drawn from student language proficiency testing teacher interviews. The found low due, part, methodologies based approaches...
Background and objectives Diaphragmatic paralysis following supraclavicular brachial plexus block (SCBPB) is ascribed to phrenic nerve palsy. This study investigated the effect of 2 volumes 0.375% ropivacaine on efficacy as a surgical anesthetic an analgesic examined diaphragm compound muscle action potentials (CMAPs) pulmonary function before after SCBPB. Methods Eighty patients scheduled for removal hardware internal fixation healing upper limb fracture distal shoulder were randomized...
The D-alanylation of lipoteichoic acid (LTA) allows the Gram-positive organism to modulate its surface charge, regulate ligand binding, and control electromechanical properties cell wall. incorporation D-alanine into LTA requires D-alanine:D-alanyl carrier protein ligase (AMP-forming) (Dcl) (Dcp). high-resolution solution structure 81-residue (8.9 kDa) Dcp has been determined by multidimensional heteronuclear NMR. An ensemble 30 structures was calculated using torsion angle dynamics approach...
A novel handheld pseudo random coded ultra-wideband (UWB) radar for human sensing applications is presented in this paper. In order to reduce the size of and obtain good penetrability, center frequency m-sequence assigned about 1.1 GHz. The peak voltage 4.5 Vpp, while length can be chosen different signal-to-noise ratio (SNR). digital transmitter, dual-channel receiver clock synchronization are discussed detail. experimental results show that proposed UWB has detection performance complex...
An efficient algorithm based on the frequency scaling (FSA) for terahertz (THz) stepped-frequency (SF) synthetic aperture radar (SAR) imaging is proposed in this article. THz SF SAR has an urgent application demand close-range medical imaging, security check, and near-space military target reconnaissance. In these fields, real-time performance of great significance. The back projection (BPA) accurate time-domain algorithm, but it a huge amount calculation cannot meet requirements imaging....
Antibody-drug conjugates (ADCs) are an emerging class of biopharmaceuticals. As such, there no specific guidelines addressing impurity limits and qualification requirements. The current ICH on impurities, Q3A (Impurities in New Drug Substances), Q3B Products), Q6B (Specifications: Test Procedures Acceptance Criteria for Biotechnological/Biological Products) do not adequately address how to assess small molecule impurities ADCs. International Consortium Innovation Quality Pharmaceutical...
In this Letter, a sparse image reconstruction approach is proposed for three-dimensional (3D) terahertz (THz) surface layer holography by sharply dwindled amount of frequency samples, without reducing the high quality final reconstructed 3D THz images. To avoid range ambiguity resulting from reduction random step method adopted to evaluate rough profile layer. With obtained profile, de-ambiguity procedure demodulate echoed data greatly compress maximum nonambiguous and recover all...