A5011820779- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Protein purification and stability
- Synthesis and Characterization of Pyrroles
- Organic Chemistry Cycloaddition Reactions
- Porphyrin and Phthalocyanine Chemistry
- Molecular spectroscopy and chirality
- Biochemical and biochemical processes
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Porphyrin Metabolism and Disorders
- Enzyme Structure and Function
- Enzyme Catalysis and Immobilization
- Nanofabrication and Lithography Techniques
- Drug Transport and Resistance Mechanisms
- Neonatal Health and Biochemistry
- HIV/AIDS drug development and treatment
- Biosimilars and Bioanalytical Methods
- Synthesis and biological activity
- Pharmacological Effects of Natural Compounds
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Traditional and Medicinal Uses of Annonaceae
- Radical Photochemical Reactions
Seagen (United States)
2021-2023
Abzena (United States)
2021
Dalhousie University
2010-2015
University of Leeds
2005
Antibody–drug conjugates (ADCs) are becoming increasingly established as a mainstream therapeutic modality for oncology, with more than dozen compounds already approved marketing and hundreds of clinical trials ongoing. ADCs hybrid construct combining, via chemical conjugation, biologic (monoclonal antibody) small-molecule (drug-linker) moieties into single drug substance. They also present significant technical strategic challenges chemistry, manufacturing, controls (CMC). Within the IQ...
2,2-Bis(4-isobutylphenyl)propanoyl-CoA and 2,2-bis(4-t-butylphenyl)propanoyl-CoA are rationally designed, gem-disubstituted substrate-product analogues that competitively inhibit α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis with Ki values of 16.9 ± 0.6 21 4 μM, respectively, exceeding the enzyme's affinity for substrate by approximately 5-fold.
Antibody–drug conjugates (ADCs) are increasingly prevalent as investigational and marketed treatments for a variety of cancers other diseases. The structures most ADCs comprise small-molecule component (the drug-linker) chemically conjugated to monoclonal antibody, this hybrid construct presents number challenges Chemistry, Manufacturing, Controls (CMC) development. A Small Molecule Considerations ADC Development Working Group (WG) has been established within the IQ Consortium serve forum...
Membrane chromatography is routinely used to remove host cell proteins, viral particles, and aggregates during antibody downstream processing. The application of membrane the field antibody-drug conjugates (ADCs) has been applied in a limited capacity only specialized scenarios. Here, we utilized characteristics adsorbers, Sartobind® S Phenyl, for aggregate payload clearance while polishing ADC single chromatographic run. was removal excess payload, Phenyl polish by unwanted drug-to-antibody...
An analogue of orotidine 5′-monophosphate (OMP), 6-phosphonouridine is a competitive inhibitor OMP decarboxylase from E. coli, binding with an affinity similar to that OMP. Hence the active site capable stabilizing negative charge distributed out plane pyrimidine ring, consistent notion ground state destabilization.
An efficient, optimized, and scalable process for the synthesis of C-ring ester-functionalized prodigiosenes has been developed by (i) exploiting a silylative Mukaiyama aldol strategy condensation alkyl 5-formyl-2,4-dimethylpyrrole-3-carboxylate 4-methoxy-3-pyrrolin-2-one to form corresponding dipyrrinone analogues, (ii) developing facile stable bromodipyrrin analogues use in formal Suzuki coupling reactions. The was applied three multigram scales (up 6.5 g prodigiosene free-base) with...
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