A5102332502- T-cell and B-cell Immunology
- Sperm and Testicular Function
- Dementia and Cognitive Impairment Research
- Immune Cell Function and Interaction
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nutritional Studies and Diet
- Systemic Lupus Erythematosus Research
- Tea Polyphenols and Effects
- Seaweed-derived Bioactive Compounds
- Reproductive Biology and Fertility
- Vitamin D Research Studies
- Genomics and Chromatin Dynamics
- Bone health and treatments
- Crustacean biology and ecology
- Peroxisome Proliferator-Activated Receptors
- Developmental Biology and Gene Regulation
- CRISPR and Genetic Engineering
- Atherosclerosis and Cardiovascular Diseases
- Folate and B Vitamins Research
- Polysaccharides and Plant Cell Walls
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Aging and Gerontology Research
- Diet and metabolism studies
Jinan University
2024-2025
Tianjin Medical University General Hospital
2023-2025
Air Force General Hospital PLA
2024
Air Force Medical University
2024
Yangzhou University
2024
Chinese Academy of Sciences
2024
Tianjin Medical University
2020-2023
Zhejiang Chinese Medical University
2023
China Academy of Chinese Medical Sciences
2022
Zhejiang University
2019-2021
Background:Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial. Objective:To determine whether 12-month improves cognitive function elderly subjects with mild cog nitive impairment (MCI), it mediated through the mechanism which telomere length (TL) regulate oxidative stress. Methods:This was double-blind, randomized, placebo-controlled trial Tianjin, China. Participants were all native...
Regulatory T cells (Tregs) play critical roles in inhibiting antitumor immunity, which is dependent on FOXP3-mediated transcriptional activity. However, no Treg-specific therapeutics has been approved for clinical use. We performed a high-throughput screen of FDA-approved drugs potential inhibitors FOXP3 These efforts identified Lanatoside C (Lac), potently inhibits activity by causing degradation RUNX1, FOXP3-associated component required its Lac directly binds the E3 ligase STUB1, leading...
Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) mitochondrial DNA copy number (mtDNAcn) mediate relationship between MCI risk. The purpose present study is to evaluate whether inflammatory potential diet assessed by dietary index (DII), inflammation, LTL, mtDNAcn were associated with risk MCI.A population-based cohort was conducted total 2944 participants. During median...
Agonistic antibodies against CD137 have been demonstrated to completely regress established tumors through activating T cell immunity. Unfortunately, current failed benefit patients with cancer. Moreover, their antitumor mechanisms in vivo remain be determined. Here, we report the development of a small molecular agonist, JNU-0921. JNU-0921 effectively activates both human and mouse direct binding extracellular domains induce oligomerization signaling shrinks vivo. Mechanistically, enhances...
An anti-CD30 antibody-drug conjugate incorporating the antimitotic agent DM1 and a stable SMCC linker, anti-CD30-MCC-DM1, was generated as new antitumor drug candidate for CD30-positive hematological malignancies. Here, in vitro vivo pharmacologic activities of anti-CD30-MCC-DM1 (also known F0002-ADC) were evaluated compared with ADCETRIS (brentuximab vedotin). Pharmacokinetics (PK) safety profiles cynomolgus monkeys assessed. Anti-CD30-MCC-DM1 effective cell death assays using lymphoma...
Abstract Objective The objective of this study was to explore the efficacy and safety belimumab among Chinese patients with SLE in a real-world setting. Methods A prospective cohort performed, taking on background standard-of-care (SoC) treatment were consecutively enrolled from July 2021 December 2022. Based baseline characteristics, divided into three groups: newly diagnosed group, relapsed group refractory group. Patients within 4 weeks starting belimumab. relapse had experienced severe...
Abstract Background and purpose Cardiovascular risk burden in midlife has been linked to cognitive decline later life, but whether this association still exists older cohorts is unclear. Methods The between the cardiovascular score function was investigated using 9‐year follow‐up data. algorithms were from Chinese guidelines on prevention treatment of dyslipidemia adults (2016 revised), which assessed at baseline categorized into tertiles (low, middle high). Full intelligence quotient (FIQ),...
PIWI proteins play important roles in germline development the mammals. However, functions of PIWIs crustaceans remain unknown. In present study, we identified three Piwis from testis Eriocheir sinensis (E. sinensis). Three Piwi genes encoded with typical features subfamilies and were highly expressed testis. could be detected cytoplasm spermatocytes spermatids, while spermatozoa, only detect PIWI1 PIWI3 nucleus. The knockdown by dsRNA significantly affected formation nuclei which resulted...
Abstract Background: Antibody-drug conjugates (ADCs) play a key role in targeted therapy of solid tumors. However, few studies have examined the impact ADCs on tumor microenvironment (TME), particularly innate immune cells. To elucidate this, this study focuses investigating comprehensive impacts ICAM1-DXd microenvironment, especially tumor-associated neutrophils (TAN) and its synergistic effect with PD-1 immunotherapy. Methods: Firstly, efficacy prognosis ICAM1-DXd, potent ADC for cervical...
Neutral Lipid Storage Disease with Myopathy (NLSDM) is a rare lipid metabolism disorder caused by PNPLA2 gene mutations. Clinical manifestations are heterogeneous, and diagnosis often delayed, usually gaining patients' attention due to the increased risk of cardiomyopathy. We herein report 36-year-old Asian male presenting progressive limb weakness, muscle atrophy limbs trunk, dysarthria, heart failure. Electromyography indicated myogenic changes, biopsy results revealed characteristics...
Abstract. This paper discusses the application of perspective transform-based monocular camera depth estimation method in monitoring safety distance between construction machinery and power lines. The traditional measurement relies on manual operation, which is inefficient not precise enough, while based deep learning can improve accuracy, but faces high equipment cost a large amount training data. In contrast, transformation proposed this utilizes mathematical physical principles to...
Background: High cognitive reserve (CR) and Apolipoprotein E polymorphism ε4 (APOE ε4) non-carriers are associated with lower risk of dementia, while their relationship trajectories remains unclear. We aimed to analyze the association lifespan CR trajectories, stratification APOE ε4.Methods: 3540 Chinese older adults aged 60 above from Tianjin Elderly Nutrition Cognition (TENC) cohort study were analyzed. Lifespan was composed by education duration, occupational attainment social activities....
Abstract Research background: Neuropathic pain (NP), which is caused by nerve injury or other diseases damages patients’ life quality seriously. Anemoside B4 (AB4) the active component of triterpenoid saponins in traditional Chinese medicine Pulsatilla, with prominent effects anti-inflammation and analgesia. However, its pharmacological mechanisms acting on NP remains unclear. Methods: The analgesia AB4 against were investigated basis spinal ligation (SNL) rat model detecting thresholds...
Background: Recent findings suggest that both dietary protein intake and hand grip strength (HGS) were associated with cognitive function, however, few studies have been devoted specifically to the mediation effect of HGS on association function. Objectives: To confirm hypothesis mediated function in elderly, which was modified by triglyceride level methylenetetrahydrofolate reductase (MTHFR) gene status. Methods: This cross-sectional study included 3,268 participants. Dietary intake, HGS,...
Spermatogenesis is a complicated and highly regulated male gamete differentiation process that begins with the proliferation of spermatogonia to release mature spermatozoa. The autophagy-related gene <i>atg7</i> has been reported as closely related spermatogenesis communication Sertoli cell-germ cells in mice, including acrosome biogenesis, sperm flagellum development, ectoplasmic specialization assembly. However, function es-ATG7 its molecular regulatory mechanism during Crustacea remain...