Selin Jessa
A5068723052- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Pituitary Gland Disorders and Treatments
- Testicular diseases and treatments
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Lipid metabolism and disorders
- Genomics and Phylogenetic Studies
- Sarcoma Diagnosis and Treatment
Stanford University
2025
McGill University
2018-2024
Jewish General Hospital
2018-2024
University of British Columbia
2021
McGill University Health Centre
2020
Simon Fraser University
2016-2018
Abstract Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis strongly associated with molecular subgroup, although the driver mutations that distinguish two main subgroups remain poorly defined. Through integrative analysis of whole genomes, exomes, and transcriptomes, we have uncovered genes non-coding loci are commonly mutated in DLBCL. Our has identified novel cis -regulatory sites, implicates recurrent 3′ UTR NFKBIZ as a mechanism...
Abstract More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion (formerly C11orf95–RELA). To study the biology ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) embryonic brain. Integrative epigenomic and transcriptomic mapping was performed on IUE-driven ZRfus tumors by CUT&RUN, chromatin immunoprecipitation sequencing, assay for transposase-accessible RNA sequencing compared with human ZRfus-driven ependymoma. In...
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events the PFA linear genome led us to search its 3D for characteristic features. Here, we reconstructed genomes from diverse childhood tumor types uncovered global topology that highly reminiscent stem progenitor cells variety human tissues. remarkable feature exclusively present are type B ultra long-range interactions PFAs (TULIPs), regions separated by great...
Down syndrome (DS), caused by the triplication of human chromosome 21, leads to significant alterations in brain development and is a major genetic cause intellectual disability. While much known about changes neurons DS, effects trisomy 21 on non-neuronal cells such as astrocytes are poorly understood. Astrocytes critical for function, their alteration may contribute DS pathophysiology. To better understand impact astrocytes, we performed RNA-sequencing from newly produced induced...
<p>Bulk RNAseq projections by ssGSEA.</p>
<p>Orthotopic engraftment of cell lines derived from Foxr2 p53LOF murine model.</p>
<p><i>Foxr2</i> is oncogenic in the ventral telencephalon mice. <b>A,</b> Schematic describing IUE-based strategy to model <i>FOXR2</i>-driven brain tumors. PiggyBac and CRISPR vectors are delivered into neural stem cells GEs at E12.5. After birth, mice develop tumors euthanized when neurologic symptoms become apparent. <b>B,</b> Representative brightfield (BF) fluorescence (GFP) images of a GFP+ <i>Foxr2</i>-driven tumor...
<p>Foxr2 chromatin binding sites in <i>Foxr2</i> p53<sup>LOF</sup> neurosphere show enrichment ETS and glial pathways. <b>A,</b> Validation of FOXR2 overexpression p53 downregulation <i>ex vivo</i><i>Foxr2</i> neurospheres by qRT-PCR. <b>B,</b> <i>Nkx2-1</i>, <i>Lhx6</i>, <i>Dlx5</i>, <i>Dlx6</i>, <i>Emx2</i>, <i>Sox10</i>,...
<p><i>FOXR2</i> does not induce expression of MGE or EC-NB TFs. <b>A,</b> Bulk RNA-seq telencephalon patterning Top and third rows, tumor samples from this study cohort. Second row, (Gartlgruber colleagues, ref. <a href="#bib21" target="_blank">21</a>) subset to high risk, stage 4 with <i>FOXR2</i> (normalized >2). Bottom H9 human NSCs transduced HA-FOXR2 controls HcRed (Tsai href="#bib7" target="_blank">7</a>). All box plots...
<p>Mouse models transcriptomically recapitulate human NB-FOXR2. <b>A,</b> Heatmap showing CNVs in <i>Foxr2</i> p53<sup>LOF</sup> and alone models, computed with inferCNV. <b>B,</b> Top, Uniform Manifold Approximation Projection (UMAP) joint representation of mouse model single-cell datasets (<i>n</i> = 3) without integration or batch correction. Cells colored by broad cell class derived from automated type annotation,...
<p>NB-FOXR2 tumors transcriptionally resemble interneurons and OPC cells. <b>A,</b><i>t</i>-Distributed stochastic neighbor embedding (<i>t</i>-SNE) of bulk RNA-seq profiles pediatric brain (left) with stage 4 high-risk EC-NBs from Gartlgruber colleagues (ref. <a href="#bib21" target="_blank">21</a>; right) using ssGSEA scores for <i>N</i> = 374 cell type–specific gene signatures reference scRNA-seq datasets....
<p>Quality control (QC) metrics and copy-number variation for scRNAseq datasets of NB-FOXR2 patient tumors.</p>