A5006156482- Nasolacrimal Duct Obstruction Treatments
- Nonmelanoma Skin Cancer Studies
- Cancer Treatment and Pharmacology
- Ophthalmology and Eye Disorders
- Ocular Oncology and Treatments
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Head and Neck Surgical Oncology
- Chronic Myeloid Leukemia Treatments
- Chemotherapy-related skin toxicity
- Single-cell and spatial transcriptomics
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Cellular Mechanics and Interactions
- Hematopoietic Stem Cell Transplantation
University of Toronto
2004-2024
3M (United States)
2018
Mashhad University of Medical Sciences
2017
McGill University
2016
University of Illinois Chicago
2008-2010
Yale University
2004-2007
The University of Texas MD Anderson Cancer Center
2001-2004
The University of Texas at Austin
2004
Plastic Surgery Hospital
2002
Fundación Juan March
2002
Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival the tumorigenic population. Using CRISPR-Cas9 approaches patient-derived GBM stem cells (GSCs) interrogate function coding genome, we identify actionable pathways responsible for growth, which reveal gene-essential circuitry stemness proliferation. In particular, characterize members SOX transcription factor family, SOCS3, USP8, DOT1L, protein ufmylation as important GSC growth....
Developmental signal transduction pathways act diversely, with context-dependent roles across systems and disease types. Glioblastomas (GBMs), which are the poorest prognosis primary brain cancers, strongly resemble developmental systems, but these growth processes have not been exploited therapeutically, likely in part due to extreme cellular genetic heterogeneity observed tumors. The role of Wnt/βcatenin signaling GBM stem cell (GSC) renewal fate decisions remains controversial. Here, we...
To evaluate the outcomes among patients with adenoid cystic carcinoma of lacrimal gland treated at various stages their disease a tertiary care cancer center.A retrospective case series 20 single institution between 1952 and 2002. Clinical records were available for all patients; histologic sections from 12 review. Disease-free survival was measured completion treatment; overall date initial diagnosis.The study included 6 men 14 women. The mean age diagnosis 39.5 years. median follow-up time...
Cell morphology and geometry affect cellular processes such as stem cell differentiation, suggesting that these parameters serve fundamental regulators of biological within the cell. Hierarchical architectures featuring micro- nanotopographical features therefore offer programmable systems for differentiation. However, a limited number studies have explored effects hierarchical due to complexity fabricating with rationally tunable nanostructuring. Here, we report three-dimensional (3D)...
Abstract STI571 (imatinib mesylate; Gleevec) is a selective inhibitor of the bcr‐abl, c‐kit, and platelet‐derived growth factor receptor tyrosine kinases. Mild periorbital edema has been noted as common side effect in Phase I II trials this drug for treatment patients with chronic myelogenous leukemia gastrointestinal stromal tumors. The authors report case male patient age 63 years who developed severe after leukemia. His was enough to cause visual obstruction due lower eyelid festoons that...
In Brief Purpose: To describe one center's experience with sentinel lymph node (SLN) biopsy in patients eyelid and conjunctival malignancies performed a smaller volume of technetium than was initially used small incision directly overlying the node(s). Methods: A noncomparative interventional case series 13 clinically negative regional nodes who underwent SLN for or at The University Texas M. D. Anderson Cancer Center between May 2002 July 2003. Preoperative lymphoscintigraphy an injection...
The current study was conducted to report the severity and management of canalicular nasolacrimal duct stenosis as a side effect docetaxel therapy outcomes surgical intervention for this condition.The records 148 patients with epiphora associated who were evaluated at Ophthalmology Service University Texas M. D. Anderson Cancer Center reviewed. frequency administration, dose intensity, cumulative docetaxel, any concomitant chemotherapeutic agents recorded. Each patient underwent an...
To evaluate the practice patterns among surgeons who treat melanomas of eyelid skin with respect to margins excision and look for possible correlation between incidence local regional recurrence distant metastasis.A retrospective survey members American Society Ophthalmic Plastic Reconstructive Surgery European yielded 44 cases. The patients' age, sex, date diagnosis, histologic classification melanoma, Breslow thickness, Clark level, location size excision, findings or metastasis were...
The stress associated with starvation is accompanied by compensatory behaviours that enhance foraging efficiency and increase the probability of encountering food. However, molecular details how hunger triggers changes in activity neural circuits to elicit these adaptive behavioural outcomes remains be resolved. We show here AMP-activated protein kinase (AMPK) regulates neuronal appropriate response acute starvation, this effect mediated coordinated modulation glutamatergic inputs. AMPK...
In Brief Purpose To determine the feasibility of preoperative lymphoscintigraphy for identification sentinel lymph nodes (SLNs) in patients with conjunctival and periocular skin tumors to patterns lymphatic drainage from such tumors. Methods We retrospectively reviewed records all biopsy-confirmed malignancies who underwent or without SLN biopsy between January 1999 June 2000. Patients 0.3 1 mCi technetium Tc-99m sulfur colloid a volume either 0.2 mL mL. Images were taken as soon first SLNs...
In Brief Purpose To identify histopathologic changes in the lacrimal sac and nasal mucosa caused by docetaxel 3 patients with canalicular narrowing nasolacrimal duct obstruction. Methods Small case series. Lacrimal mucosal specimens were obtained at time of dacryocystorhinostomy or during silicone intubation to correct epiphora receiving docetaxel. Histologic evaluation was performed. Results Extensive fibrotic stroma prominent histologic features all patients. A biopsy specimen taken from...
In Brief A 50-year-old woman presented with a 5-year history of unilateral epiphora that began shortly after 131I therapy for thyroid carcinoma. recent recombinant human thyroid-stimulating hormone (Thyrogen) scan had shown focus uptake adjacent to the right eye was initially thought be possible metastasis. Probing and irrigation revealed complete blockage nasolacrimal duct. The patient underwent dacryocystorhinostomy (DCR) biopsy lacrimal sac. Histopathologic examination sac nasal mucosa...
Dynamic modulation of cellular phenotypes between the epithelial and mesenchymal states-the epithelial-mesenchymal transition (EMT) mesenchymal-epithelial (MET)-plays an important role in cancer progression. Nanoscale topography culture substrates is known to affect migration EMT cells. However, existing platforms heavily rely on simple geometries such as grooved lines or cylindrical post arrays, which may oversimplify complex interaction cells nanotopography vivo. Here, we use...
To describe the clinical features and histologic classification of orbital lymphoma secondary to systemic non-Hodgkin lymphoma, evaluate efficacy various treatment modalities for controlling component disease, analyze vision-related outcomes.In this retrospective case series, records patients diagnosed with who were treated between January 1999 May 2001 at University Texas M.D. Anderson Cancer Center reviewed. Demographic data, immunophenotype, stage outcomes, duration follow-up after...
To describe the surgical treatment and outcomes in patients with metastatic breast cancer canalicular stenosis caused by weekly docetaxel.This case series included 10 persistent epiphora due to docetaxel treatment, who were evaluated probing irrigation of tear drainage apparatus found have significant stenosis. The severity was graded clinically. Each patient underwent bicanalicular silicone intubation or dacryocystorhinostomy (DCR) placement either a tube (canaliculo DCR) pyrex glass...