The aim of the present study was to investigate antihyperglycemic and protective potential crocin, a pharmacologically active constituent Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses 15, 30, 60 mg/kg body weight for 6 weeks. levels thiobarbituric acid reactive substance (TBARS) total thiol (SH) groups measured liver kidney end Under our experimental conditions, dose found significantly reduce blood glucose level animals....

ABSTRACT The purpose of the present study was to investigate effect crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model Parkinson’s disease. Male Wistar rats were subjected unilateral injection 6-OHDA (16 µg) into medial forebrain bundle treated with (30 60 mg/kg) for six weeks. tested performance at weeks after infusion, then killed estimation biochemical parameters. increase thiobarbituric acid reactive substances (TBARS) nitrite levels hippocampus...

In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration a high dose estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. Sham-Est OVX-Est groups were treated with (4 mg/kg) for 12 weeks. Escape latency traveled path in the significantly higher than Sham OVX (p<0.01 p<0.001). probe trial, animals spent lower time Q1 compared (p<0.05 groups, tissue total thiol concentration lower,...

ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well hyperalgesia in 6-OHDA-lesioned rat model Parkinson's disease. animals were subjected to unilateral microinjection 6-OHDA into medial forebrain bundle treated with (25, 50 100 mg/kg, ip) for six weeks after surgery. rats showed contralateral rotations towards lesion side, which was accompanied by learning a passive avoidance test decrease tail withdrawal latency flick at end week 6. results...

Hyperlipidemia is an associated complication of diabetes mellitus. Lowering serum lipid levels seems to be with a decrease in the risk vascular disease and related complications. The purpose current study was evaluate antihyperglycemic antihyperlipidemic effects hydroalcoholic extract Securigera securidaca seeds streptozotocin-induced diabetic rats.Female Wistar rats were randomly divided into four groups as follows: Control, diabetic, treated at doses 100 200 mg/kg. animals rendered by...

Several studies support hypolipidemic effect of fenugreek in normal and diabetic subjects. However, very little is known about the possible direct action on adipose tissue. The present study was designed to investigate effects seeds adipogenesis lipolysis. Preadipocytes were isolated from tissue rats differentiated adipocyte presence ethanolic extract seeds. this lipolysis also evaluated fat rats. Fenugreek led a significant reduction lipid droplet accumulation as with Oil Red O staining....

Background: Diabetic neuropathy is one of the serious problems due to microvessel vasculopathy in diabetes. It has been reported that hyperglycemia and hypertriglyceridemia are underlying mechanisms inducing progression diabetic neuropathy. The aim present study was investigate effects melatonin on serum glucose lipid levels, as well food consumption water intake streptozotocin-induced rats. Materials Methods: Eighty male Wistar rats were randomly assigned six groups including; normal...

<italic>Levisticum officinale</italic> (Apiaceae) has been identified as a medicinal plant in traditional medicine, with the anti-inflammatory, antioxidant, and anticholinesterase activities.

Carvacrol is a natural phenolic monoterpene with anti-inflammatory and antioxidant bioactivities. Neuroinflammatory oxidative stress responses play crucial role in the pathogenesis of Alzheimer's disease. The present study examined effect carvacrol on brain tumor necrosis factor-alpha (TNF-α) level as well spatial learning memory performances lipopolysaccharide (LPS)-exposed rats.The rats were treated either (25 50 mg/kg) or Tween 80 for 2 weeks. Thereafter, LPS (1 saline was...

Crocin is considered to prevent oxidative stress-related diseases, such as ischemia and Alzheimer's. The aim of the present investigation was evaluate effects crocin on motor behaviour 6-OHDA-induced oxidative/nitrosative damage striatum in an experimental model Parkinson's disease.Left medial forebrain bundle lesioned by microinjection 6-OHDA (16μg 0.2% ascorbate-saline). (30 60 mg/kg) injected intraperitoneally three days before surgery until six weeks. Rotational biochemical analysis were...

Sesamol is a phenolic lignan extracted from sesame seeds, and it possesses anti-inflammatory antioxidant activities. Lipopolysaccharide (LPS) known to produce neuroinflammatory responses memory impairment. The current study aimed investigate the protective influence of sesamol against LPS-mediated neuroinflammation impairment.Sesamol (10 50 mg/kg) was injected Wistar rats for two weeks. Then, animals received LPS injection (1 five days, while treatment with performed 30 min before injection....

The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior oxidative stress biomarkers in a 6-OHDA-lesioned rat model Parkinson's disease. Wistar rats were treated with at dose 25 mg/kg and/or ran for week. Then, 6-OHDA microinjected into medial forebrain bundle treatments continued six more weeks. Aversive memory, assessed end week six. group showed significant increase decrease step-through latency passive...