ABSTRACT The purpose of the present study was to investigate effect crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model Parkinson’s disease. Male Wistar rats were subjected unilateral injection 6-OHDA (16 µg) into medial forebrain bundle treated with (30 60 mg/kg) for six weeks. tested performance at weeks after infusion, then killed estimation biochemical parameters. increase thiobarbituric acid reactive substances (TBARS) nitrite levels hippocampus...

Background: It has been recently demonstrated that Royal jelly (RJ) a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine effect RJ spatial memory in rats after intracerebroventricular injection streptozotocin (icv-STZ). Materials Methods: Rats were infused bilaterally an icv STZ, while sham received vehicle only. The feed RJ-contained food (3% w/w) (lyophilized mixed...

ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well hyperalgesia in 6-OHDA-lesioned rat model Parkinson's disease. animals were subjected to unilateral microinjection 6-OHDA into medial forebrain bundle treated with (25, 50 100 mg/kg, ip) for six weeks after surgery. rats showed contralateral rotations towards lesion side, which was accompanied by learning a passive avoidance test decrease tail withdrawal latency flick at end week 6. results...

Summary Stress contributes, as a risk factor, to such psychological disorders anxiety. The effects of electrical lesions in the basolateral amygdala nucleus ( BLA ) were investigated on locomotor activity and anxiety‐like behaviour different stress durations. For this purpose, rats randomly allocated control, sham, experimental groups, latter including groups with without subjected acute, sub‐chronic, chronic conditions for 1, 7, 21 days, respectively, applied 6 h/d. induced anxiety was...

Stress and escitalopram (an anti-stress medication) can affect brain functions related gene expression. This study investigated the protective effects of long-term administration on memory, as well hippocampal BDNF BCL-2 expressions in rats exposed to predictable unpredictable chronic mild stress (PCMS UCMS, respectively). Male were randomly assigned different groups: control (Co), sham (Sh), (PSt USt, respectively; 2 h/day for 21 consecutive days), (Esc; 10 mg/kg with (PSt-Esc USt-Esc, The...

Introduction: Parkinson's disease is a common neurodegenerative disorder.In this disease, mitochondrial defects and oxidative s tress lead to the enhancement of free radicals death dopamine neurons in Sabs tantia nigra.The clinical symptoms are including tremor, muscle tiffness, inability walk as well cognition, memory learning deficits.Aging increases severity disease.Conclusion: Any therapeutic trategy which can modulate antioxidant homeos tasis neuroprotection may increase life expectancy...

Carvacrol is a natural phenolic monoterpene with anti-inflammatory and antioxidant bioactivities. Neuroinflammatory oxidative stress responses play crucial role in the pathogenesis of Alzheimer's disease. The present study examined effect carvacrol on brain tumor necrosis factor-alpha (TNF-α) level as well spatial learning memory performances lipopolysaccharide (LPS)-exposed rats.The rats were treated either (25 50 mg/kg) or Tween 80 for 2 weeks. Thereafter, LPS (1 saline was...

Impairment of learning and memory processes has been demonstrated by many studies using different stressors. Other reports suggested that exercise a powerful behavioral intervention to improve cognitive function brain health. In this research, we investigated protective effects treadmill running on chronic stress-induced deficit in rats.Fifty male Wistar rats were randomly divided into five groups (n=10) as follows: Control (Co), Sham (Sh), Stress (St), Exercise (Ex) (St & Ex) groups....

Alzheimer's disease is associated to impairments of learning and memory. Because studies demonstrated that erythropoietin has positive effects on central nervous system, the aim this study was evaluate effect spatial memory in a well defined model for disease. Rat created by injecting streptozotocin lateral ventricles brain. Two weeks later, rats were assessed through passive avoidance test confirm induction Alzheimer's. After that, they received (5000IU/kg) every other day, two then 5-day...

The basolateral amygdala (BLA) modulates memory for emotional events and is involved in both stress memory. This study investigated different durations of the role BLA on serum corticosterone level spatial cognitive memory.Different (acute, mid, chronic stress), with without lesion were induced rats by 6 h/day restraint 1, 7, 21 days. Memory functions evaluated novel object recognition (NOR) location test (OLT).The OLT findings showed locomotor activity slightly decreased stress. NOR...

It has been demonstrated that exercise neuroprotective effects in the central nervous system (CNS), especially hippocampus. Previous studies have indicated diabetes mellitus affects synaptic plasticity hippocampus leading to impairments learning and memory. The aim of this study was evaluate treadmill running on at dentate gyrus (DG) streptozotocin-induced diabetic rats.Experimental groups were control, diabetes-exercise groups. Long-term potentiation (LTP) perforant path-DG synapses...

Crocin is considered to prevent oxidative stress-related diseases, such as ischemia and Alzheimer's. The aim of the present investigation was evaluate effects crocin on motor behaviour 6-OHDA-induced oxidative/nitrosative damage striatum in an experimental model Parkinson's disease.Left medial forebrain bundle lesioned by microinjection 6-OHDA (16μg 0.2% ascorbate-saline). (30 60 mg/kg) injected intraperitoneally three days before surgery until six weeks. Rotational biochemical analysis were...

The aim of this study was to investigate the effect short-term forced exercise protocol on passive avoidance retention in morphine-exposed rats. Effects morphine acquisition and retrieval have been proven paradigms. Twenty four male Wistar rats weighing 250-300 g were used study. Animals randomly divided into groups including: (1) non-morphine-exposed without (nA.nE) (2) with (nA.E) (3) (A.nE) (4) (A.E). Rats ran as motorized treadmill 1 h daily for ten days. Morphine-exposed animals...