The aim of the present study was to investigate antihyperglycemic and protective potential crocin, a pharmacologically active constituent Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses 15, 30, 60 mg/kg body weight for 6 weeks. levels thiobarbituric acid reactive substance (TBARS) total thiol (SH) groups measured liver kidney end Under our experimental conditions, dose found significantly reduce blood glucose level animals....

Objectives:Oxidative stress plays a central role in diabetes-induced complications.In the present study, protevtive effect of Artemisia turanica (A.turanica) was evaluated against liver oxidative and dysfunction.Methods: Fifty male Wistar rats were randomly divided into five groups: control, diabetic, diabetic + metformin, A. extract, extract metformin.Experimental diabetes induced by single-dose (55 mg/kg, intraperitoneally (ip)) injection streptozotocin (STZ).Metformin (300 mg/kg) (70...

Abstract Hypoglycemic, anti‐inflammatory, and antioxidant activities of fennel have been recorded in numerous investigations. The study aimed to evaluate the protective effects or its active component trans ‐Anethole (TA) on streptozotocin‐induced liver injury rats. Rats were injected with a single dose STZ (65 mg/kg) treated (200 400 mg/kg), TA (80 metformin (300 for 35 days. Serum lipid profile enzyme activity (aminotransferases), oxidative stress markers, degree fibrosis tissue assessed....

We investigated the potential of galangal rhizomes to induce cytotoxic and apoptotic effects in cultured human breast carcinoma cell line, (MCF-7) compare with non-malignant (MRC-5) cells. Both cells were DMEM medium treated for three consecutive days. The percentage was determined by flow cytometry using Annexin-V fluorescein isothiocyanate. results showed that ethanolic extract decreased viability malignant as a concentration- time- dependent manner. IC50 values against MCF-7 at 400.0 ±...

Several studies support hypolipidemic effect of fenugreek in normal and diabetic subjects. However, very little is known about the possible direct action on adipose tissue. The present study was designed to investigate effects seeds adipogenesis lipolysis. Preadipocytes were isolated from tissue rats differentiated adipocyte presence ethanolic extract seeds. this lipolysis also evaluated fat rats. Fenugreek led a significant reduction lipid droplet accumulation as with Oil Red O staining....

The current study was carried out to determine whether the aqueous-ethanolic extract or butanolic fraction of Nigella sativa (NS) seeds could prevent reduce calculi aggregation in experimental calcium oxalate nephrolithiasis Wistar rats.Male rats were randomly divided into 5 groups: group A received tap drinking water for 28 days. Groups B, C, D and E 1% ethylene glycol induction (CaOx) calculus formation Rats groups also NS, N-butanol phase remnant respectively, at a dose 250 mg/kg Urine...

The role of ovarian hormones, nitric oxide, and their interaction on learning memory has been widely investigated. present study was carried out to evaluate the effect Acute (A) Chronic (C) L-Arginine (L-Arg) administration in ovariectomized (OVx) rats. Forty-five rats were divided into six groups: 1) sham, 2) OVx, 3) sham-L-Arg-A, 4) OVx-L-Arg-A, 5) sham-L-Arg-C, 6) OVx-L-Arg-C. animals sham-L-Arg-A OVx-L-Arg-A acutely treated with 500 mg/kg L-Arg during 5 test days. Sham-L-Arg-C...

Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) an herbaceous plant with many pharmacologic effects. In present study, we evaluated protective effects aqueous-ethanolic extract N. and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive (100 mg/kg), (100,200 + treatment E, (100, 200 mg/kg)....

We have previously reported that C-peptide modulates insulin-mediated inhibition of lipolysis and glucose consumption but has no significant effects per se on adipose tissue normal rats. It been repeatedly observed certain actions are restricted to the diabetic states. In present study, therefore, we examined whether alters in Rats were rendered by streptozotocin divided into 2 groups; insulin treated untreated. Retroperitoneal was excised aseptically, subjected organ culture incubated with...

The effect of levothyroxine (L-T4) on the learning and memory impairment induced by streptozotocin (STZ) brain tissue oxidative damage in rats was evaluated. An animal model Alzheimer's disease (AD) established intracerebroventricular injection STZ (3 mg/kg) male Wistar (250 ± 50 g). After that, were treated for 3 weeks with L-T4 (10, 100 μg/kg) or normal saline. Passive avoidance (PA) spatial evaluated using shuttle box Morris water maze (MWM), respectively. Finally, euthanized, their blood...

The role of ovarian hormones, nitric oxide, and their interaction on learning memory has been widely investigated. objective present study was to investigate different effects chronic administration inducible oxide synthase inhibitor, aminoguanidine (AM) ovariectomized (OVX) naïve (Sham) female rats. Thirty-two rats were divided into four groups: 1) Sham, 2) OVX, 3) Sham-AM 4) OVX-AM. animals OVX-AM chronically received 100 mg/kg/day during 8 weeks before 5 test days. in Sham OVX groups 1...

Diabetes mellitus is associated with dysregulation of adipose tissue metabolism and increased level serum lipids. In our previous work we found that Securigera securidaca decreases cholesterol in blood diabetic rats. The present study was carried out to further investigate the effects this plant on lipid metabolism, lipolysis, adipogenesis, Female Wistar rats were rendered by intraperitoneal injection streptozotocin. Retroperitoneal removed from animals after seven days streptozotocin...

In the present study, impact of a combination four memory-enhancer herbs on cognitive impairment and brain tissue oxidative damage due to hypothyroidism was evaluated. Propylthiouracil (PTU; 0.05%) administrated in drinking water. Rats were treated with herbal products (Cyperus rotundus, Crocus sativus, Piper nigrum, Boswellia serrata) mixed honey at two doses (640 1,280 mg/kg) or donepezil (0.5 mg/kg), for 6 weeks. Memory performance Morris water maze (MWM) avoidance behavior passive...

Doxorubicin (DOX) is an antineoplastic agent which it's clinical use has been limited due to its major side effects including cardiotoxicity and nephrotic syndrome. Sesame oil (SO) important edible with many pharmacologic effects. The aim of the present study was investigate effect SO against DOX-induced nephropathy in rat. In this study, two doses (3 6 mL/kg) were administrated orally for six consecutive weeks DOX (mg/kg) intravenously injected on 4th day experiment. Blood urine samples...