A5025326671- Coenzyme Q10 studies and effects
- Biochemical Acid Research Studies
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Macrophage Migration Inhibitory Factor
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Muscle and Compartmental Disorders
- Probiotics and Fermented Foods
- Energetic Materials and Combustion
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Renin-Angiotensin System Studies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Natural Antidiabetic Agents Studies
- Stress Responses and Cortisol
- Nigella sativa pharmacological applications
Tabriz University of Medical Sciences
2022-2025
Mashhad University of Medical Sciences
2018-2021
Objective(s): Considering the poor prognosis of ischemic heart disease and diminished effectiveness cardioprotective interventions in elderly, it becomes necessary to investigate interaction aging with protection during myocardial ischemia/reperfusion injury (IRI). This study was conducted assess impact mitoquinone (MitoQ) alpha-lipoic acid (ALA) preconditioning on cardioprotection following IRI aged rats.MethodsFifty male Wistar rats (22–24 months old) were divided into five groups...
Abstract Ischaemic heart diseases (IHD) are among the major causes of mortality in elderly population. Although timely reperfusion is a common treatment for IHD, it additional damage to ischaemic myocardium known as ischaemia–reperfusion (IR) injury. Considering importance preventing injuries, we aimed examine combination effect mitochondrial transplantation (MT) and coenzyme Q 10 (CoQ ) myocardial IR injury aged male rats. Seventy‐two Wistar rats were randomly divided into six groups: Sham,...
Ischemia/reperfusion (IR)-induced ventricular arrhythmia, which mainly occurs after the opening of coronary artery occlusion, poses a clinical problem. This study aims to investigate effectiveness pretreatment with coenzyme Q10 (CoQ10) in combination mitochondrial transplantation on IR-induced arrhythmias aged rats. Myocardial IR induction was performed by left anterior descending occlusion for 30 min, followed re-opening 24 hr. CoQ10 administered intraperitoneally at dosage 10 mg/kg/day two...
Introduction: Inadequate control of diabetes mellitus (DM) leads to considerable cardiovascular implications like diabetic cardiomyopathy (DCM). Cardiomyocyte apoptosis is one the main mechanisms DCM pathogenesis associated with hyperglycemia, oxidative stress, inflammation, hyperlipidemia and several other factors. Trigonella foenum-graecum (Fenugreek) has been long used as a traditional medicine many therapeutic effects, including anti-diabetic, anti-hyperlipidemia, anti-inflammatory...
This study aimed to investigate the effects of combined alpha-lipoic acid (ALA) and mitoquinone (Mito Q) supplementation on cardiac function underlying mechanisms in aged rats with myocardial infarction (MI). The underwent left anterior descending artery (LADA) occlusion for 30 min, followed by reperfusion 24 h. ALA (100 mg/kg, gavage) Mito Q (10 IP) were administered daily two weeks before ischemia. Cardiac function, inflammatory, apoptotic markers evaluated h after results this indicated...
The effect of levothyroxine (L-T4) on the learning and memory impairment induced by streptozotocin (STZ) brain tissue oxidative damage in rats was evaluated. An animal model Alzheimer's disease (AD) established intracerebroventricular injection STZ (3 mg/kg) male Wistar (250 ± 50 g). After that, were treated for 3 weeks with L-T4 (10, 100 μg/kg) or normal saline. Passive avoidance (PA) spatial evaluated using shuttle box Morris water maze (MWM), respectively. Finally, euthanized, their blood...
Abstract Background: Ischemic heart diseases (IHD) are among the major causes of mortality in elderly population. Although timely reperfusion is a commen treatment for IHD, it also additional damage to ischemic myocardium known as ischemia/reperfusion (IR) injury. Considering importance preventing injuries, we aimed examine combination effect mitochondrial transplantation and coenzyme Q 10 (CoQ ) myocardial IR injury aged rats. Methods: Seventy-two male Wistar rats were randomly divided into...
Abstract This study aimed to investigate whether a combination of two potent antioxidants, alpha-lipoic acid (ALA) and mitoquinone (Mito Q), could improve myocardial function the underlying mechanisms in an experimental model infarction aged rats. To develop rats left anterior descending artery (LADA) was transiently occluded for 30 minutes then re-perfused 24 hours. Mito Q (10 mg/kg, IP) ALA (100 gavage) given daily 2 weeks before occlusion LADA. Subsequently, hours after ischemia,...